name: midbrain-hindbrain boundary maturation
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def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus maturation" RELATED 
synonym: "MHB maturation" RELATED 
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of: GO:0030917 ! midbrain-hindbrain boundary development
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