Category:GO:0019643 ! reductive tricarboxylic acid cycle

name: reductive tricarboxylic acid cycle
namespace: biological_process
alt_id: GO:0019644
def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028]
synonym: "reductive carboxylate cycle" EXACT []
synonym: "reductive carboxylic acid cycle" EXACT []
synonym: "reductive citric acid pathway" EXACT []
synonym: "reductive Kreb's cycle" EXACT []
synonym: "reductive TCA cycle" EXACT []
is_a: GO:0015977 ! carbon fixation

AmiGO <GOterm>GO:0019643</GOterm>
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