Category:GO:0006540 ! gamma-aminobutyrate shunt

name: gamma-aminobutyrate shunt
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438]
comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
synonym: "4-aminobutyrate shunt" EXACT []
synonym: "degradation of glutamate to succinate through GABA" EXACT [MetaCyc:GLUDEG-I-PWY]
synonym: "GABA shunt" EXACT []
synonym: "gamma aminobutyrate shunt" EXACT []
synonym: "glutamate decarboxylation to succinate" EXACT []
synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY]
synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY]
xref: MetaCyc:GLUDEG-I-PWY
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
relationship: has_part: GO:0004351 ! glutamate decarboxylase activity
relationship: has_part: GO:0034386 ! 4-aminobutyrate:2-oxoglutarate transaminase activity

AmiGO <GOterm>GO:0006540</GOterm>
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