Category:GO:0006127 ! glycerol-3-phosphate shuttle

name: glycerol-3-phosphate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle." [GOC:sjm, PMID:16368075]
synonym: "glycerol phosphate shuttle" EXACT []
synonym: "glycerophosphate shuttle" EXACT []
xref: MetaCyc:PWY-6118
is_a: GO:0006734 ! NADH metabolic process
is_a: GO:0019674 ! NAD+ metabolic process
relationship: has_part: GO:0004368 ! glycerol-3-phosphate dehydrogenase (quinone) activity
relationship: has_part: GO:0141152 ! glycerol-3-phosphate dehydrogenase (NAD+) activity

AmiGO <GOterm>GO:0006127</GOterm>
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