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Category:GO:0004164 ! diphthine synthase activity
name: diphthine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine." [PMID:15485916, PMID:20873788, PMID:3042777, RHEA:36415]
comment: This activity is present in archae and produces the trimethylated product diphthine, which is converted into diphthamide by diphthine-ammonia ligase activity ; GO:0017178 (EC:6.3.1.14). Note that this is different from the eukaryotic enzyme diphthine methyl ester synthase activity ; GO:0141133 (EC:2.1.1.314), which produces diphthine methyl ester.
synonym: "diphthine methyltransferase activity" RELATED [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" RELATED [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" RELATED [EC:2.1.1.98]
xref: EC:2.1.1.98
xref: MetaCyc:RXN-14326
xref: RHEA:36415
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
AmiGO
<GOterm>GO:0004164</GOterm>
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