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CVHSA:VEMP
Contents
| Species (Taxon ID) | Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndromecoronavirus). (227859) | |
| Gene Name(s) | E (synonyms: sM) | |
| Protein Name(s) | Envelope small membrane protein
E protein sM protein | |
| External Links | ||
| UniProt | P59637 | |
| EMBL | AY278741 AY274119 AY304492 AY282752 AY278554 AY278491 AY283794 AY283795 AY283796 AY283797 AY283798 AY278487 AY278488 AY278489 AY278490 AY279354 AY291451 AY310120 AY291315 AY297028 AY323975 AY321118 AY463059 AY338174 AY338175 AY348314 AP006557 AP006558 AP006559 AP006560 AP006561 AY323977 AY362698 AY362699 AY427439 | |
| RefSeq | NP_828854.1 | |
| PDB | 2MM4 | |
| PDBsum | 2MM4 | |
| ProteinModelPortal | P59637 | |
| GeneID | 1489671 | |
| Proteomes | UP000000354 | |
| GO | GO:0044178 GO:0016021 GO:0019031 GO:0055036 GO:0006915 | |
| InterPro | IPR003873 | |
| Pfam | PF02723 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0046760 |
viral budding from Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044177 |
host cell Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0044662 |
disruption by virus of host cell membrane |
ECO:0000314 |
P |
Figure 2B indicates cells that express E have increased permeability. ONPG is a compound that will, typically, only enter bacterial cells if the cell membrane becomes permeable. ONPG can be converted into a colored compound by β-Galactosidase. The O.D. from this colored compound was measured and the results indicate the E protein increases permeability of the cell membrane. |
complete | |||||
|
involved_in |
GO:0044662 |
disruption by virus of host cell membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044177 |
host cell Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044178 |
host cell Golgi membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Li, Y et al. (2014) Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins. J. Biol. Chem. 289 12535-49 PubMed GONUTS page
- ↑ Cohen, JR et al. (2011) Identification of a Golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein. J. Virol. 85 5794-803 PubMed GONUTS page
- ↑ 3.0 3.1 Liao, Y et al. (2004) Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability. Biochem. Biophys. Res. Commun. 325 374-80 PubMed GONUTS page
