CVHOC:HEMA

Species (Taxon ID)	Human coronavirus OC43 (HCoV-OC43). (31631)
Gene Name(s)	HE
Protein Name(s)	Hemagglutinin-esterase HE protein E3 glycoprotein
External Links
UniProt	P30215
EMBL	M76373 AY391777 AY585228 AY585229
PIR	A39450
RefSeq	NP_937949.1
ProteinModelPortal	P30215
SMR	P30215
GeneID	2648209
Proteomes	UP000007552
GO	GO:0020002 GO:0016021 GO:0019031 GO:0055036 GO:0001681 GO:0019064 GO:0019058
InterPro	IPR008980 IPR007142 IPR003860
Pfam	PF03996 PF02710
SUPFAM	SSF49818

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019058	viral infectious cycle	PMID:23283955	ECO:0000315			P		HE in human coronavirus plays a significant role in the production of an infectious virus, even though the S protein is the main viral factor in coronavirus infection. Figure 4 demonstrates the significant role HE also plays in the production of an infectious viral product. When a functional HE was added to the mutated transfectant, more viral antigens were produced. Figure 4C demonstrates the larger amount of viral antigens present in the transfectants with a functional HE compared to the pcDNA transfectant. Figure 4D demonstrates the significant amount of viral antigens who originally had a mutated HE protein were transfected with a functional HE protein. Therefore, it is apparent that the HE protein plays a significant role in producing infectious viruses.	complete CACAO 7940
enables	GO:0001681	sialate O-acetylesterase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15776	F		Seeded From UniProt	complete
involved_in	GO:0019058	viral life cycle	PMID:23283955	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044650	adhesion of symbiont to host cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046789	P		Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003860 InterPro:IPR007142	F		Seeded From UniProt	complete
part_of	GO:0019031	viral envelope	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003860 InterPro:IPR007142 InterPro:IPR008980	C		Seeded From UniProt	complete
involved_in	GO:0019064	fusion of virus membrane with host plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003860 InterPro:IPR007142 InterPro:IPR008980	P		Seeded From UniProt	complete
enables	GO:0046789	host cell surface receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003860 InterPro:IPR007142 InterPro:IPR008980	F		Seeded From UniProt	complete
enables	GO:0001681	sialate O-acetylesterase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.1.53	F		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0019031	viral envelope	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0261	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946	C		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0375	C		Seeded From UniProt	complete
part_of	GO:0055036	virion membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0275	C		Seeded From UniProt	complete
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