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CLOBO:BXD
Contents
| Species (Taxon ID) | Clostridium botulinum. (1491) | |
| Gene Name(s) | botD | |
| Protein Name(s) | Botulinum neurotoxin type D
BoNT/D Bontoxilysin-D Botulinum neurotoxin D light chain Botulinum neurotoxin D heavy chain | |
| External Links | ||
| UniProt | P19321 | |
| EMBL | X54254 S49407 | |
| PIR | S11455 | |
| PDB | 2FPQ 3N7J 3OBR 3OBT 3OGG 3RMX 3RMY 5BQM 5BQN | |
| PDBsum | 2FPQ 3N7J 3OBR 3OBT 3OGG 3RMX 3RMY 5BQM 5BQN | |
| ProteinModelPortal | P19321 | |
| BRENDA | 3.4.24.69 | |
| Reactome | R-HSA-5250955 | |
| EvolutionaryTrace | P19321 | |
| GO | GO:0005576 GO:0044164 GO:0044156 GO:0044231 GO:0016021 GO:0004222 GO:0008320 GO:0008270 GO:0051609 GO:0009405 GO:0071806 | |
| Gene3D | 2.60.120.200 3.90.1240.10 | |
| InterPro | IPR000395 IPR013320 IPR011065 IPR013104 IPR012928 IPR012500 | |
| Pfam | PF01742 PF07951 PF07953 PF07952 | |
| PRINTS | PR00760 | |
| SUPFAM | SSF49899 SSF50386 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044164 |
host cell cytosol |
ECO:0000314 |
C |
Figure 6a. Shows that Baf A1pre-treatment drastically decreased cleavage of synaptobrevin 2 by BoNT/D and GFP-BoNT/D evidencing that both proteins pass through acidic compartments en route delivering the catalytic domain to the cytosol. Figure 6b. Shows that GFP-BoNT/D co-localizes with transferrin |
complete | |||||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:1905576 |
ganglioside GT1b binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008320 |
protein transmembrane transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046929 |
negative regulation of neurotransmitter secretion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000395 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008320 |
protein transmembrane transporter activity |
Reactome:R-HSA-5250616 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bade, S et al. (2004) Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates. J. Neurochem. 91 1461-72 PubMed GONUTS page
- ↑ Arndt, JW et al. (2006) Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity. Biochemistry 45 3255-62 PubMed GONUTS page
- ↑ Strotmeier, J et al. (2010) Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem. J. 431 207-16 PubMed GONUTS page
