GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CLOBO:BXB
Contents
| Species (Taxon ID) | Clostridium botulinum. (1491) | |
| Gene Name(s) | botB | |
| Protein Name(s) | Botulinum neurotoxin type B
BoNT/B Bontoxilysin-B Botulinum neurotoxin B light chain Botulinum neurotoxin B heavy chain | |
| External Links | ||
| UniProt | P10844 | |
| EMBL | M81186 Z11934 X70817 | |
| PIR | A48940 | |
| PDB | 1EPW 1F31 1F82 1G9A 1G9B 1G9C 1G9D 1I1E 1S0B 1S0C 1S0D 1S0E 1S0F 1S0G 1Z0H 2ETF 2NM1 2NP0 2XHL 3ZUQ 4KBB | |
| PDBsum | 1EPW 1F31 1F82 1G9A 1G9B 1G9C 1G9D 1I1E 1S0B 1S0C 1S0D 1S0E 1S0F 1S0G 1Z0H 2ETF 2NM1 2NP0 2XHL 3ZUQ 4KBB | |
| ProteinModelPortal | P10844 | |
| SMR | P10844 | |
| DIP | DIP-42782N | |
| IntAct | P10844 | |
| MINT | MINT-1795550 | |
| BindingDB | P10844 | |
| ChEMBL | CHEMBL1075064 | |
| MEROPS | M27.002 | |
| Reactome | REACT_200782 | |
| EvolutionaryTrace | P10844 | |
| GO | GO:0044164 GO:0044156 GO:0044231 GO:0016021 GO:0004222 GO:0008270 GO:0051609 GO:0007269 GO:0009405 GO:0007268 | |
| Gene3D | 2.60.120.200 3.90.1240.10 | |
| InterPro | IPR000395 IPR013320 IPR011065 IPR013104 IPR012928 IPR012500 | |
| Pfam | PF01742 PF07951 PF07953 PF07952 | |
| PRINTS | PR00760 | |
| SUPFAM | SSF49899 SSF50386 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008320 |
protein transmembrane transporter activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008320 |
protein transmembrane transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046929 |
negative regulation of neurotransmitter secretion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000395 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044161 |
host cell cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044221 |
host cell synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044156 |
host cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044164 |
host cell cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044231 |
host cell presynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Schiavo, G et al. (1992) Botulinum neurotoxins are zinc proteins. J. Biol. Chem. 267 23479-83 PubMed GONUTS page
- ↑ Montal, M (2010) Botulinum neurotoxin: a marvel of protein design. Annu. Rev. Biochem. 79 591-617 PubMed GONUTS page
b
h
- GO:0044161 ! host cell cytoplasmic vesicle
- GO:0044164 ! host cell cytosol
- GO:0030430 ! host cell cytoplasm
- GO:0044156 ! host cell junction
- GO:0033644 ! host cell membrane
- GO:0020002 ! host cell plasma membrane
- GO:0044231 ! host cell presynaptic membrane
- GO:0044221 ! host cell synapse
- GO:0016787 ! hydrolase activity
m
p
