CLOBO:BXA2

Species (Taxon ID)	Clostridium botulinum. (1491)
Gene Name(s)	botA (synonyms: atx, bna)
Protein Name(s)	Botulinum neurotoxin type A BoNT/A Bontoxilysin-A BOTOX Botulinum neurotoxin A light chain Botulinum neurotoxin A heavy chain
External Links
UniProt	Q45894
EMBL	X73423 X87974
PIR	I40645
RefSeq	YP_002803127.1
PDB	1E1H 2G7K 2G7N 2G7P 2G7Q
PDBsum	1E1H 2G7K 2G7N 2G7P 2G7Q
ProteinModelPortal	Q45894
SMR	Q45894
DIP	DIP-437N
GeneID	7766540
KEGG	cby:CLM_0897
PATRIC	19378373
KO	K06011
OrthoDB	EOG67T5DS
EvolutionaryTrace	Q45894
GO	GO:0044164 GO:0044156 GO:0044231 GO:0016021 GO:0004222 GO:0008270 GO:0051609 GO:0009405
Gene3D	2.60.120.200 3.90.1240.10
InterPro	IPR000395 IPR013320 IPR011065 IPR013104 IPR012928 IPR012500
Pfam	PF01742 PF07951 PF07953 PF07952
PRINTS	PR00760
SUPFAM	SSF49899 SSF50386

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008320	P		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F		Seeded From UniProt	complete
	GO:0006508	proteolysis	PMID:18511418	ECO:0000269			P		Figure 2: Botulinum toxin proteolytic activity on VAMP.	complete CACAO 3313
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012928	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F		Seeded From UniProt	complete
enables	GO:0008320	protein transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500 InterPro:IPR012928	P		Seeded From UniProt	complete
involved_in	GO:0046929	negative regulation of neurotransmitter secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395 InterPro:IPR012500 InterPro:IPR012928 InterPro:IPR013104	P		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0044156	host cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1031	C		Seeded From UniProt	complete
part_of	GO:0044221	host cell synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1051	C		Seeded From UniProt	complete
part_of	GO:0044161	host cell cytoplasmic vesicle	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1036 UniProtKB-SubCell:SL-0386	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
part_of	GO:0044164	host cell cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0384	C		Seeded From UniProt	complete
part_of	GO:0044231	host cell presynaptic membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0434	C		Seeded From UniProt	complete
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References

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