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CLOBO:BXA1
Contents
| Species (Taxon ID) | Clostridium botulinum. (1491) | |
| Gene Name(s) | botA (synonyms: atx, bna) | |
| Protein Name(s) | Botulinum neurotoxin type A
BoNT/A Bontoxilysin-A BOTOX Botulinum neurotoxin A light chain Botulinum neurotoxin A heavy chain | |
| External Links | ||
| UniProt | P10845 | |
| EMBL | X52066 M30196 X92973 D67030 M27892 | |
| PIR | A35294 | |
| RefSeq | WP_003356619.1 | |
| PDB | 1UEE 1XTF 1XTG 2ILP 2IMA 2IMB 2IMC 2ISE 2ISG 2ISH 2NYY 2NZ9 2VU9 2VUA 2W2D 3BOK 3BON 3BOO 3BTA 3BWI 3C88 3C89 3C8A 3C8B 3DDA 3DDB 3DS9 3FUO 3V0A 3V0B 3V0C 3ZUR 3ZUS 4EJ5 4EL4 4ELC 4HEV 4IQP 4JRA | |
| PDBsum | 1UEE 1XTF 1XTG 2ILP 2IMA 2IMB 2IMC 2ISE 2ISG 2ISH 2NYY 2NZ9 2VU9 2VUA 2W2D 3BOK 3BON 3BOO 3BTA 3BWI 3C88 3C89 3C8A 3C8B 3DDA 3DDB 3DS9 3FUO 3V0A 3V0B 3V0C 3ZUR 3ZUS 4EJ5 4EL4 4ELC 4HEV 4IQP 4JRA | |
| ProteinModelPortal | P10845 | |
| SMR | P10845 | |
| DIP | DIP-42781N | |
| IntAct | P10845 | |
| MINT | MINT-1795451 | |
| BindingDB | P10845 | |
| ChEMBL | CHEMBL5192 | |
| TCDB | 1.C.8.1.1 | |
| eggNOG | NOG119715 | |
| Reactome | REACT_200737 | |
| EvolutionaryTrace | P10845 | |
| GO | GO:0044164 GO:0044156 GO:0044231 GO:0016021 GO:0004222 GO:0008270 GO:0051609 GO:0007269 GO:0009405 GO:0007268 | |
| Gene3D | 2.60.120.200 3.90.1240.10 | |
| InterPro | IPR000395 IPR013320 IPR011065 IPR013104 IPR012928 IPR012500 | |
| Pfam | PF01742 PF07951 PF07953 PF07952 | |
| PRINTS | PR00760 | |
| SUPFAM | SSF49899 SSF50386 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:1905576 |
ganglioside GT1b binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008320 |
protein transmembrane transporter activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008320 |
protein transmembrane transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046929 |
negative regulation of neurotransmitter secretion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000395 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044161 |
host cell cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044221 |
host cell synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044156 |
host cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044164 |
host cell cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044231 |
host cell presynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Rummel, A et al. (2004) The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction. Mol. Microbiol. 51 631-43 PubMed GONUTS page
- ↑ Schiavo, G et al. (1992) Botulinum neurotoxins are zinc proteins. J. Biol. Chem. 267 23479-83 PubMed GONUTS page
- ↑ Montal, M (2010) Botulinum neurotoxin: a marvel of protein design. Annu. Rev. Biochem. 79 591-617 PubMed GONUTS page
b
h
- GO:0044161 ! host cell cytoplasmic vesicle
- GO:0044164 ! host cell cytosol
- GO:0030430 ! host cell cytoplasm
- GO:0044156 ! host cell junction
- GO:0033644 ! host cell membrane
- GO:0020002 ! host cell plasma membrane
- GO:0044231 ! host cell presynaptic membrane
- GO:0044221 ! host cell synapse
- GO:0016787 ! hydrolase activity
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