CHICK:SCX

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SCX
Protein Name(s)	Basic helix-loop-helix transcription factor scleraxis
External Links
UniProt	P59101
EMBL	AF505881
RefSeq	NP_989584.1
UniGene	Gga.49818
ProteinModelPortal	P59101
GeneID	374101
KEGG	gga:374101
CTD	567817
HOVERGEN	HBG036149
InParanoid	P59101
PhylomeDB	P59101
NextBio	20813620
Proteomes	UP000000539
GO	GO:0005634 GO:0003677 GO:0071773 GO:0044344 GO:0006355 GO:0061056 GO:0035989 GO:0006351
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:11585810^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061056	sclerotome development	PMID:15253939^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	PMID:15253939^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035989	tendon development	PMID:11585810^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000543	positive regulation of gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
involved_in	GO:0061056	sclerotome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0061035	regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0035993	deltoid tuberosity development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0035992	tendon formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0035990	tendon cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0035989	tendon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0035914	skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
involved_in	GO:0003188	heart valve formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0003179	heart valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	P	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64124 ensembl:ENSMUSP00000043668	F	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7RTU7 ensembl:ENSP00000476384	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7RTU7 ensembl:ENSP00000476384	F	Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7RTU7 ensembl:ENSP00000476384	F	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7RTU7 ensembl:ENSP00000476384	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7RTU7 ensembl:ENSP00000476384	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7RTU7 ensembl:ENSP00000476384	C	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schweitzer, R et al. (2001) Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development 128 3855-66 PubMed GONUTS page
↑ ^2.0 ^2.1 Brent, AE & Tabin, CJ (2004) FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development 131 3885-96 PubMed GONUTS page

[PMID:11585810-1] 1.0 ^1.1 Schweitzer, R et al. (2001) Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development 128 3855-66 PubMed GONUTS page

[PMID:15253939-2] 2.0 ^2.1 Brent, AE & Tabin, CJ (2004) FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development 131 3885-96 PubMed GONUTS page

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CHICK:SCX

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