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CHICK:Q9PVG4

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) No Information Provided.
Protein Name(s) CTwist (ECO:0000313 with EMBL:AAF00072.1)

Twist1 (ECO:0000313 with EMBL:DAA06060.1)

External Links
UniProt Q9PVG4
EMBL AF093816
BK006263
RefSeq NP_990070.1
UniGene Gga.3973
ProteinModelPortal Q9PVG4
GeneID 395491
KEGG gga:395491
CTD 7291
HOVERGEN HBG019071
KO K09069
PhylomeDB Q9PVG4
NextBio 20815571
PRO PR:Q9PVG4
Gene3D 4.10.280.10
InterPro IPR011598
Pfam PF00010
SMART SM00353
SUPFAM SSF47459
PROSITE PS50888

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1902725

negative regulation of satellite cell differentiation

PMID:10825239[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000594)

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:10825239[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000594)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18353304[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0002062)

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:18353304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002062)

Seeded From UniProt

complete

involved_in

GO:2000793

cell proliferation involved in heart valve development

PMID:18353304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002062)

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:18353304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002062)

Seeded From UniProt

complete

involved_in

GO:0060973

cell migration involved in heart development

PMID:18353304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002062)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:18353304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:18353304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060421

positive regulation of heart growth

PMID:24019406[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:24019406[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0004160)
  • occurs_in:(UBERON:0001136)

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:15735646[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9PVG4

F

Seeded From UniProt

complete

involved_in

GO:2000802

positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:2000793

cell proliferation involved in heart valve development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:2000276

negative regulation of oxidative phosphorylation uncoupler activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:2000147

positive regulation of cell motility

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

enables

GO:0070888

E-box binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

F

Seeded From UniProt

complete

involved_in

GO:0061309

cardiac neural crest cell development involved in outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0060363

cranial suture morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0048704

embryonic skeletal system morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0048642

negative regulation of skeletal muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0045843

negative regulation of striated muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0045596

negative regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0044092

negative regulation of molecular function

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

F

Seeded From UniProt

complete

involved_in

GO:0042733

embryonic digit morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0035359

negative regulation of peroxisome proliferator activated receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0035137

hindlimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0035116

embryonic hindlimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0035115

embryonic forelimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0035067

negative regulation of histone acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0030326

embryonic limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

F

Seeded From UniProt

complete

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

F

Seeded From UniProt

complete

involved_in

GO:0003253

cardiac neural crest cell migration involved in outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0003203

endocardial cushion morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0003183

mitral valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26687
ensembl:ENSMUSP00000040089

P

Seeded From UniProt

complete

involved_in

GO:2000793

cell proliferation involved in heart valve development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:2000780

negative regulation of double-strand break repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:2000773

negative regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:2000147

positive regulation of cell motility

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:2000144

positive regulation of DNA-templated transcription, initiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0071639

positive regulation of monocyte chemotactic protein-1 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

enables

GO:0070888

E-box binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

F

Seeded From UniProt

complete

involved_in

GO:0061029

eyelid development in camera-type eye

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0060900

embryonic camera-type eye formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0045668

negative regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

enables

GO:0043425

bHLH transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

F

Seeded From UniProt

complete

involved_in

GO:0033128

negative regulation of histone phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0032000

positive regulation of fatty acid beta-oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0030500

regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

C

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15672
ensembl:ENSP00000242261

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011598
InterPro:IPR036638

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Leshem, Y et al. (2000) Hepatocyte growth factor (HGF) inhibits skeletal muscle cell differentiation: a role for the bHLH protein twist and the cdk inhibitor p27. J. Cell. Physiol. 184 101-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Shelton, EL & Yutzey, KE (2008) Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development. Dev. Biol. 317 282-95 PubMed GONUTS page
  3. 3.0 3.1 Schlueter, J & Brand, T (2013) Subpopulation of proepicardial cells is derived from the somatic mesoderm in the chick embryo. Circ. Res. 113 1128-37 PubMed GONUTS page
  4. Firulli, BA et al. (2005) Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat. Genet. 37 373-81 PubMed GONUTS page