CHICK:Q9DD46

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ALDH6 (ECO:0000313 with EMBL:AAG33934.1) (synonyms: ALDH1A3 (ECO:0000313 with Ensembl:ENSGALP00000011537))
Protein Name(s)	Aldehyde dehydrogenase-6 (ECO:0000313 with EMBL:AAG33934.1) Retinaldehyde dehydrogenase 3 (ECO:0000313 with EMBL:AAG38487.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000011537)
External Links
UniProt	Q9DD46
EMBL	AADN03005927 AF152358 AF246710
RefSeq	NP_990000.1
UniGene	Gga.3807
SMR	Q9DD46
STRING	9031.ENSGALP00000011537
Ensembl	ENSGALT00000011551
GeneID	395389
KEGG	gga:395389
CTD	220
eggNOG	COG1012
GeneTree	ENSGT00760000118999
HOGENOM	HOG000271505
HOVERGEN	HBG000097
KO	K00129
OMA	EGSDNYI
OrthoDB	EOG7PS1F7
PhylomeDB	Q9DD46
TreeFam	TF300455
NextBio	20815473
PRO	PR:Q9DD46
Proteomes	UP000000539
GO	GO:0005737 GO:0004029 GO:0004030 GO:0070403 GO:0070324 GO:0060324 GO:0042472 GO:0007626 GO:0050885 GO:0021768 GO:0060166 GO:0002072 GO:0043065 GO:0048386 GO:0042574 GO:0002138 GO:0060013
Gene3D	3.40.309.10 3.40.605.10
InterPro	IPR016161 IPR016163 IPR016160 IPR029510 IPR016162 IPR015590
Pfam	PF00171
SUPFAM	SSF53720
PROSITE	PS00070 PS00687

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0004029	aldehyde dehydrogenase (NAD) activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0012036 MGI:MGI:1861722 PANTHER:PTN000192421 RGD:2087 RGD:620252 RGD:68409 RGD:69219 SGD:S000000875 SGD:S000005901 UniProtKB:O75891 UniProtKB:P00352 UniProtKB:P05091 UniProtKB:P08157 UniProtKB:P48644 UniProtKB:P49189 UniProtKB:Q3SY69	F	Seeded From UniProt	complete
involved_in	GO:0048386	positive regulation of retinoic acid receptor signaling pathway	PMID:11013254^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	F	Seeded From UniProt	complete
involved_in	GO:0042574	retinal metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	P	Seeded From UniProt	complete
involved_in	GO:0042573	retinoic acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
enables	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	F	Seeded From UniProt	complete
involved_in	GO:0002138	retinoic acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	P	Seeded From UniProt	complete
enables	GO:0001758	retinal dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47895 ensembl:ENSP00000332256	F	Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	F	Seeded From UniProt	complete
involved_in	GO:0070384	Harderian gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
enables	GO:0070324	thyroid hormone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	F	Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0060166	olfactory pit development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0060013	righting reflex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0048048	embryonic eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0043584	nose development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0042573	retinoic acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0031076	embryonic camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0021768	nucleus accumbens development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	C	Seeded From UniProt	complete
enables	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	F	Seeded From UniProt	complete
enables	GO:0004029	aldehyde dehydrogenase (NAD) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	F	Seeded From UniProt	complete
involved_in	GO:0002138	retinoic acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
involved_in	GO:0002072	optic cup morphogenesis involved in camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHW9 ensembl:ENSMUSP00000015278	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024RC95 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024RC95 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024RC95 ensembl:ENSP00000332256	C	Seeded From UniProt	complete
involved_in	GO:0006081	cellular aldehyde metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012394	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015590 InterPro:IPR016160 InterPro:IPR016161 InterPro:IPR016162 InterPro:IPR016163 InterPro:IPR029510	F	Seeded From UniProt	complete
enables	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016163	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012394 InterPro:IPR015590 InterPro:IPR016160 InterPro:IPR016161 InterPro:IPR016162 InterPro:IPR016163 InterPro:IPR029510	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Grün, F et al. (2000) Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development. J. Biol. Chem. 275 41210-8 PubMed GONUTS page

[PMID:21873635-1] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11013254-2] Grün, F et al. (2000) Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development. J. Biol. Chem. 275 41210-8 PubMed GONUTS page

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CHICK:Q9DD46

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