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CHICK:Q8UWF3

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) MADH2 (ECO:0000313 with EMBL:CAC85407.1) (synonyms: SMAD2 (ECO:0000313 with Ensembl:ENSGALP00000023645))
Protein Name(s) Mothers against decapentaplegic homolog (ECO:0000256 with RuleBase:RU361195)

MAD homolog (ECO:0000256 with RuleBase:RU361195) Mothers against DPP homolog (ECO:0000256 with RuleBase:RU361195) SMAD family member (ECO:0000256 with RuleBase:RU361195)

External Links
UniProt Q8UWF3
EMBL AC192060
AJ318063
RefSeq NP_989892.1
UniGene Gga.44120
SMR Q8UWF3
STRING 9031.ENSGALP00000038855
PaxDb Q8UWF3
Ensembl ENSGALT00000023691
ENSGALT00000039647
GeneID 395247
KEGG gga:395247
CTD 4087
eggNOG NOG320700
GeneTree ENSGT00760000119091
HOGENOM HOG000286018
HOVERGEN HBG053353
KO K04500
OMA SYPDQTR
OrthoDB EOG7W1540
PhylomeDB Q8UWF3
TreeFam TF314923
Reactome REACT_195006
REACT_195008
REACT_197117
REACT_197118
REACT_198067
REACT_211903
REACT_214793
REACT_236930
NextBio 20815336
Proteomes UP000000539
GO GO:0005737
GO:0005634
GO:0005667
GO:0003677
GO:0003700
GO:0046332
GO:0042327
GO:0007184
GO:0006351
GO:0007179
Gene3D 2.60.200.10
3.90.520.10
InterPro IPR013790
IPR003619
IPR013019
IPR017855
IPR001132
IPR008984
PANTHER PTHR13703
Pfam PF03165
PF03166
SMART SM00523
SM00524
SUPFAM SSF49879
SSF56366
PROSITE PS51075
PS51076

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:20071511[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002295)
  • part_of:(CL:0000202)|part_of:(UBERON:0002295)
  • part_of:(CL:0005014)

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:12665510[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8UWF3

F

Seeded From UniProt

complete

involved_in

GO:0042327

positive regulation of phosphorylation

PMID:12665510[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8UWF3

P

Seeded From UniProt

complete

involved_in

GO:0060390

regulation of SMAD protein signal transduction

PMID:12665510[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8UWF3

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:15558476[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0011004)
  • part_of:(CL:0002224)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15558476[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0011004)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17592637[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0011004)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21308853[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000023)

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019
InterPro:IPR036578

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page
  2. 2.0 2.1 2.2 Schmierer, B et al. (2003) Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary. J. Biol. Chem. 278 21197-203 PubMed GONUTS page
  3. 3.0 3.1 Beebe, D et al. (2004) Contributions by members of the TGFbeta superfamily to lens development. Int. J. Dev. Biol. 48 845-56 PubMed GONUTS page
  4. Rajagopal, R et al. (2007) Intracellular mediators of transforming growth factor beta superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo. BMC Cell Biol. 8 25 PubMed GONUTS page
  5. Diaz, FJ et al. (2011) Early avian follicular development is characterized by changes in transcripts involved in steroidogenesis, paracrine signaling and transcription. Mol. Reprod. Dev. 78 212-23 PubMed GONUTS page