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CHICK:PGH2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) PTGS2 (synonyms: CEF-147)
Protein Name(s) Prostaglandin G/H synthase 2

Cyclooxygenase-2 COX-2 Mitogen-inducible PGHS PHS II Prostaglandin H2 synthase 2 PGH synthase 2 PGHS-2 Prostaglandin-endoperoxide synthase 2

External Links
UniProt P27607
EMBL M64990
PIR A38630
RefSeq NP_001161190.1
NP_001161191.1
UniGene Gga.4401
ProteinModelPortal P27607
SMR P27607
STRING 9031.ENSGALP00000008111
PeroxiBase 4107
PaxDb P27607
GeneID 396451
KEGG gga:396451
CTD 5743
eggNOG NOG39991
HOGENOM HOG000013149
HOVERGEN HBG000366
InParanoid P27607
KO K11987
OrthoDB EOG7RFTHC
PhylomeDB P27607
TreeFam TF329675
Reactome REACT_194363
REACT_198071
REACT_245396
UniPathway UPA00662
NextBio 20816492
PRO PR:P27607
Proteomes UP000000539
ExpressionAtlas P27607
GO GO:0005737
GO:0005789
GO:0005634
GO:0051213
GO:0020037
GO:0046872
GO:0004601
GO:0004666
GO:0019371
GO:0006954
GO:0001516
GO:0008217
GO:0006979
Gene3D 1.10.640.10
InterPro IPR029576
IPR000742
IPR010255
IPR019791
PANTHER PTHR11903:SF8
Pfam PF03098
PRINTS PR00457
SUPFAM SSF48113
PROSITE PS50026
PS50292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0020037

heme binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05769

F

Seeded From UniProt

complete

involved_in

GO:0019371

cyclooxygenase pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05769

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05769

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05769

C

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05769

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q05769

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

C

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

F

Seeded From UniProt

complete

involved_in

GO:0019371

cyclooxygenase pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

C

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35354
ensembl:ENSP00000356438

F

Seeded From UniProt

complete

involved_in

GO:1902219

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0090336

positive regulation of brown fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0071498

cellular response to fluid shear stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0071471

cellular response to non-ionic osmotic stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

F

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0031622

positive regulation of fever generation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0031394

positive regulation of prostaglandin biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

F

Seeded From UniProt

complete

involved_in

GO:0019371

cyclooxygenase pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

C

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05769
ensembl:ENSMUSP00000035065

P

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029576

P

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

F

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029576

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029576

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029576

P

Seeded From UniProt

complete

involved_in

GO:0019371

cyclooxygenase pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029576

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255
InterPro:IPR029576

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

P

Seeded From UniProt

complete

enables

GO:0004666

prostaglandin-endoperoxide synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.99.1

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

involved_in

GO:0006693

prostaglandin metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0644

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0492

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0051213

dioxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0223

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0001516

prostaglandin biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0643
UniPathway:UPA00662

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0031090

organelle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0165

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.