CHICK:PACA

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ADCYAP1
Protein Name(s)	Glucagon family neuropeptides Growth hormone-releasing factor 1-46 GRF Growth hormone-releasing hormone GHRH Pituitary adenylate cyclase-activating polypeptide 27 PACAP-27 PACAP27 Pituitary adenylate cyclase-activating polypeptide 38 PACAP-38 PACAP38
External Links
UniProt	P41534
EMBL	U71183 U71184 U71185 U67275
PIR	A61070
UniGene	Gga.51518 Gga.52384 Gga.616
ProteinModelPortal	P41534
SMR	P41534
HOVERGEN	HBG018069
InParanoid	P41534
PhylomeDB	P41534
NextBio	20818669
PRO	PR:P41534
Proteomes	UP000000539
GO	GO:0005576
InterPro	IPR000532
Pfam	PF00123
SMART	SM00070
PROSITE	PS00260

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070852	cell body fiber	PMID:11090925^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001041) part_of:(UBERON:0003104)\|part_of:(UBERON:0002256)\|part_of:(UBERON:0002179)\|part_of:(UBERON:0001759)\|part_of:(UBERON:0005363)\|part_of:(UBERON:0001043)\|part_of:(UBERON:0002116)\|part_of:(UBERON:0001153)\|part_of:(UBERON:0002257)\|part_of:(UBERON:0001807)\|part_of:(UBERON:0005052) part_of:(UBERON:0007688) part_of:(UBERON:0007357) part_of:(UBERON:0000344)\|part_of:(UBERON:0012480)	Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:11090925^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001041) part_of:(UBERON:0003104)\|part_of:(UBERON:0002256)\|part_of:(UBERON:0002179)\|part_of:(UBERON:0001759)\|part_of:(UBERON:0005363)\|part_of:(UBERON:0001043)\|part_of:(UBERON:0002116)\|part_of:(UBERON:0001153)\|part_of:(UBERON:0002257)\|part_of:(UBERON:0001807)\|part_of:(UBERON:0005052) part_of:(UBERON:0007688) part_of:(UBERON:0007357) part_of:(UBERON:0000344)\|part_of:(UBERON:0012480)	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:9629189^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0003040)\|part_of:(UBERON:0001929)\|part_of:(UBERON:0001935)\|part_of:(UBERON:0002034)\|part_of:(UBERON:0002746)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:9629189^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001877)\|part_of:(UBERON:0002667)\|part_of:(UBERON:0002746)\|part_of:(UBERON:0001935)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70176	P		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13589	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13589	P		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70176	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000130195 UniProtKB:P18509	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 UniProtKB:P41534	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 UniProtKB:P41534	C		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105094 PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:P41535 UniProtKB:Q29W19	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P		Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105094 PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:P41535 UniProtKB:Q29W19	F		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105094 MGI:MGI:95709 MGI:MGI:98933 PANTHER:PTN000130195 RGD:2037 RGD:61883 RGD:621647 UniProtKB:P01282 UniProtKB:P01284 UniProtKB:P01286 UniProtKB:P18509 UniProtKB:P41535 UniProtKB:P48143 UniProtKB:P81401 UniProtKB:Q29W19	P		Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000130195 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016521	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016521	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000532	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000532	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	P		Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	F		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	P		Seeded From UniProt	complete
enables	GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	F		Seeded From UniProt	complete
part_of	GO:0070852	cell body fiber	PMID:11090925^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001041) part_of:(UBERON:0003104)\|part_of:(UBERON:0002256)\|part_of:(UBERON:0002179)\|part_of:(UBERON:0001759)\|part_of:(UBERON:0005363)\|part_of:(UBERON:0001043)\|part_of:(UBERON:0002116)\|part_of:(UBERON:0001153)\|part_of:(UBERON:0002257)\|part_of:(UBERON:0001807)\|part_of:(UBERON:0005052) part_of:(UBERON:0007688) part_of:(UBERON:0007357) part_of:(UBERON:0000344)\|part_of:(UBERON:0012480)	Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:11090925^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001041) part_of:(UBERON:0003104)\|part_of:(UBERON:0002256)\|part_of:(UBERON:0002179)\|part_of:(UBERON:0001759)\|part_of:(UBERON:0005363)\|part_of:(UBERON:0001043)\|part_of:(UBERON:0002116)\|part_of:(UBERON:0001153)\|part_of:(UBERON:0002257)\|part_of:(UBERON:0001807)\|part_of:(UBERON:0005052) part_of:(UBERON:0007688) part_of:(UBERON:0007357) part_of:(UBERON:0000344)\|part_of:(UBERON:0012480)	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:9629189^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0003040)\|part_of:(UBERON:0001929)\|part_of:(UBERON:0001935)\|part_of:(UBERON:0002034)\|part_of:(UBERON:0002746)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:9629189^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001877)\|part_of:(UBERON:0002667)\|part_of:(UBERON:0002746)\|part_of:(UBERON:0001935)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:11514017^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002298)\|part_of:(UBERON:0001894)\|part_of:(UBERON:0001893)\|part_of:(UBERON:0002037)\|part_of:(UBERON:0000007)\|part_of:(UBERON:0000966)\|part_of:(UBERON:0001905)	Seeded From UniProt	complete
involved_in	GO:0046887	positive regulation of hormone secretion	PMID:14644645^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001905)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:14644645^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001905) part_of:(UBERON:0006134) part_of:(UBERON:0014930)	Seeded From UniProt	complete
involved_in	GO:0002118	aggressive behavior	PMID:15518899^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:15518899^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:15518899^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:15518899^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001898) part_of:(UBERON:0002298) part_of:(UBERON:0001893) part_of:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0042756	drinking behavior	PMID:15518899^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:11250943^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000031)	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Salvi, EP et al. (2000) Ontogeny of PACAP immunoreactivity in extrinsic and intrinsic innervation of chicken gut. Peptides 21 1703-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Peeters, K et al. (1998) Comparative distribution of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide immunoreactivity in the chicken forebrain. Ann. N. Y. Acad. Sci. 839 417-9 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Józsa, R et al. (2001) Distribution and daily variations of PACAP in the chicken brain. Peptides 22 1371-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Csernus, V et al. (2004) The effect of PACAP on rhythmic melatonin release of avian pineals. Gen. Comp. Endocrinol. 135 62-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Hollósy, T et al. (2004) Effects of in ovo treatment with PACAP antagonist on general activity, motor and social behavior of chickens. Regul. Pept. 123 99-106 PubMed GONUTS page
↑ Erhardt, NM et al. (2001) Early expression of pituitary adenylate cyclase-activating polypeptide and activation of its receptor in chick neuroblasts. Endocrinology 142 1616-25 PubMed GONUTS page

[PMID:11090925-1] 1.0 ^1.1 ^1.2 ^1.3 Salvi, EP et al. (2000) Ontogeny of PACAP immunoreactivity in extrinsic and intrinsic innervation of chicken gut. Peptides 21 1703-9 PubMed GONUTS page

[PMID:9629189-2] 2.0 ^2.1 ^2.2 ^2.3 Peeters, K et al. (1998) Comparative distribution of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide immunoreactivity in the chicken forebrain. Ann. N. Y. Acad. Sci. 839 417-9 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11514017-4] Józsa, R et al. (2001) Distribution and daily variations of PACAP in the chicken brain. Peptides 22 1371-7 PubMed GONUTS page

[PMID:14644645-5] 5.0 ^5.1 Csernus, V et al. (2004) The effect of PACAP on rhythmic melatonin release of avian pineals. Gen. Comp. Endocrinol. 135 62-9 PubMed GONUTS page

[PMID:15518899-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Hollósy, T et al. (2004) Effects of in ovo treatment with PACAP antagonist on general activity, motor and social behavior of chickens. Regul. Pept. 123 99-106 PubMed GONUTS page

[PMID:11250943-7] Erhardt, NM et al. (2001) Early expression of pituitary adenylate cyclase-activating polypeptide and activation of its receptor in chick neuroblasts. Endocrinology 142 1616-25 PubMed GONUTS page

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CHICK:PACA

Contents

Annotations

Notes

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