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CHICK:PACA

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) ADCYAP1
Protein Name(s) Glucagon family neuropeptides

Growth hormone-releasing factor 1-46 GRF Growth hormone-releasing hormone GHRH Pituitary adenylate cyclase-activating polypeptide 27 PACAP-27 PACAP27 Pituitary adenylate cyclase-activating polypeptide 38 PACAP-38 PACAP38

External Links
UniProt P41534
EMBL U71183
U71184
U71185
U67275
PIR A61070
UniGene Gga.51518
Gga.52384
Gga.616
ProteinModelPortal P41534
SMR P41534
HOVERGEN HBG018069
InParanoid P41534
PhylomeDB P41534
NextBio 20818669
PRO PR:P41534
Proteomes UP000000539
GO GO:0005576
InterPro IPR000532
Pfam PF00123
SMART SM00070
PROSITE PS00260

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070852

cell body fiber

PMID:11090925[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001041)
  • part_of:(UBERON:0003104)|part_of:(UBERON:0002256)|part_of:(UBERON:0002179)|part_of:(UBERON:0001759)|part_of:(UBERON:0005363)|part_of:(UBERON:0001043)|part_of:(UBERON:0002116)|part_of:(UBERON:0001153)|part_of:(UBERON:0002257)|part_of:(UBERON:0001807)|part_of:(UBERON:0005052)
  • part_of:(UBERON:0007688)
  • part_of:(UBERON:0007357)
  • part_of:(UBERON:0000344)|part_of:(UBERON:0012480)

Seeded From UniProt

complete

part_of

GO:0044297

cell body

PMID:11090925[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001041)
  • part_of:(UBERON:0003104)|part_of:(UBERON:0002256)|part_of:(UBERON:0002179)|part_of:(UBERON:0001759)|part_of:(UBERON:0005363)|part_of:(UBERON:0001043)|part_of:(UBERON:0002116)|part_of:(UBERON:0001153)|part_of:(UBERON:0002257)|part_of:(UBERON:0001807)|part_of:(UBERON:0005052)
  • part_of:(UBERON:0007688)
  • part_of:(UBERON:0007357)
  • part_of:(UBERON:0000344)|part_of:(UBERON:0012480)

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:9629189[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0003040)|part_of:(UBERON:0001929)|part_of:(UBERON:0001935)|part_of:(UBERON:0002034)|part_of:(UBERON:0002746)

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:9629189[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001877)|part_of:(UBERON:0002667)|part_of:(UBERON:0002746)|part_of:(UBERON:0001935)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70176

P

Seeded From UniProt

complete

involved_in

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13589

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13589

P

Seeded From UniProt

complete

involved_in

GO:0030073

insulin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70176

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

P

Seeded From UniProt

complete

enables

GO:0051428

peptide hormone receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130195
UniProtKB:P18509

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

P

Seeded From UniProt

complete

involved_in

GO:0045860

positive regulation of protein kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
UniProtKB:P41534

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
UniProtKB:P41534

C

Seeded From UniProt

complete

involved_in

GO:0032880

regulation of protein localization

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105094
PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:P41535
UniProtKB:Q29W19

P

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

P

Seeded From UniProt

complete

enables

GO:0016521

pituitary adenylate cyclase activating polypeptide activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105094
PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:P41535
UniProtKB:Q29W19

F

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002598721
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105094
MGI:MGI:95709
MGI:MGI:98933
PANTHER:PTN000130195
RGD:2037
RGD:61883
RGD:621647
UniProtKB:P01282
UniProtKB:P01284
UniProtKB:P01286
UniProtKB:P18509
UniProtKB:P41535
UniProtKB:P48143
UniProtKB:P81401
UniProtKB:Q29W19

P

Seeded From UniProt

complete

enables

GO:0005184

neuropeptide hormone activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130195
RGD:2037
UniProtKB:P18509
UniProtKB:Q29W19

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016521

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016521

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005184

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000532

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039080

P

Seeded From UniProt

complete

enables

GO:0016521

pituitary adenylate cyclase activating polypeptide activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039080

F

Seeded From UniProt

complete

involved_in

GO:0030073

insulin secretion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039080

P

Seeded From UniProt

complete

enables

GO:0031858

pituitary adenylate cyclase-activating polypeptide receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039080

F

Seeded From UniProt

complete

part_of

GO:0070852

cell body fiber

PMID:11090925[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001041)
  • part_of:(UBERON:0003104)|part_of:(UBERON:0002256)|part_of:(UBERON:0002179)|part_of:(UBERON:0001759)|part_of:(UBERON:0005363)|part_of:(UBERON:0001043)|part_of:(UBERON:0002116)|part_of:(UBERON:0001153)|part_of:(UBERON:0002257)|part_of:(UBERON:0001807)|part_of:(UBERON:0005052)
  • part_of:(UBERON:0007688)
  • part_of:(UBERON:0007357)
  • part_of:(UBERON:0000344)|part_of:(UBERON:0012480)

Seeded From UniProt

complete

part_of

GO:0044297

cell body

PMID:11090925[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001041)
  • part_of:(UBERON:0003104)|part_of:(UBERON:0002256)|part_of:(UBERON:0002179)|part_of:(UBERON:0001759)|part_of:(UBERON:0005363)|part_of:(UBERON:0001043)|part_of:(UBERON:0002116)|part_of:(UBERON:0001153)|part_of:(UBERON:0002257)|part_of:(UBERON:0001807)|part_of:(UBERON:0005052)
  • part_of:(UBERON:0007688)
  • part_of:(UBERON:0007357)
  • part_of:(UBERON:0000344)|part_of:(UBERON:0012480)

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:9629189[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0003040)|part_of:(UBERON:0001929)|part_of:(UBERON:0001935)|part_of:(UBERON:0002034)|part_of:(UBERON:0002746)

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:9629189[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001877)|part_of:(UBERON:0002667)|part_of:(UBERON:0002746)|part_of:(UBERON:0001935)

Seeded From UniProt

complete

part_of

GO:0005623

cell

PMID:11514017[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0002298)|part_of:(UBERON:0001894)|part_of:(UBERON:0001893)|part_of:(UBERON:0002037)|part_of:(UBERON:0000007)|part_of:(UBERON:0000966)|part_of:(UBERON:0001905)

Seeded From UniProt

complete

involved_in

GO:0046887

positive regulation of hormone secretion

PMID:14644645[5]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(UBERON:0001905)

Seeded From UniProt

complete

part_of

GO:0005623

cell

PMID:14644645[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001905)
  • part_of:(UBERON:0006134)
  • part_of:(UBERON:0014930)

Seeded From UniProt

complete

involved_in

GO:0002118

aggressive behavior

PMID:15518899[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0040011

locomotion

PMID:15518899[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:15518899[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005623

cell

PMID:15518899[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001898)
  • part_of:(UBERON:0002298)
  • part_of:(UBERON:0001893)
  • part_of:(UBERON:0002037)

Seeded From UniProt

complete

involved_in

GO:0042756

drinking behavior

PMID:15518899[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005623

cell

PMID:11250943[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000031)

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Salvi, EP et al. (2000) Ontogeny of PACAP immunoreactivity in extrinsic and intrinsic innervation of chicken gut. Peptides 21 1703-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Peeters, K et al. (1998) Comparative distribution of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide immunoreactivity in the chicken forebrain. Ann. N. Y. Acad. Sci. 839 417-9 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Józsa, R et al. (2001) Distribution and daily variations of PACAP in the chicken brain. Peptides 22 1371-7 PubMed GONUTS page
  5. 5.0 5.1 Csernus, V et al. (2004) The effect of PACAP on rhythmic melatonin release of avian pineals. Gen. Comp. Endocrinol. 135 62-9 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Hollósy, T et al. (2004) Effects of in ovo treatment with PACAP antagonist on general activity, motor and social behavior of chickens. Regul. Pept. 123 99-106 PubMed GONUTS page
  7. Erhardt, NM et al. (2001) Early expression of pituitary adenylate cyclase-activating polypeptide and activation of its receptor in chick neuroblasts. Endocrinology 142 1616-25 PubMed GONUTS page