CHICK:NOS2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	NOS2
Protein Name(s)	Nitric oxide synthase, inducible Inducible NO synthase Inducible NOS iNOS Macrophage NOS NOS type II Peptidyl-cysteine S-nitrosylase NOS2
External Links
UniProt	Q90703
EMBL	U46504 U34045 D85422
RefSeq	NP_990292.1
UniGene	Gga.3327
ProteinModelPortal	Q90703
SMR	Q90703
PaxDb	Q90703
PRIDE	Q90703
GeneID	395807
KEGG	gga:395807
CTD	4843
eggNOG	COG4362
HOGENOM	HOG000220884
HOVERGEN	HBG000159
InParanoid	Q90703
KO	K13241
PhylomeDB	Q90703
NextBio	20815875
PRO	PR:Q90703
Proteomes	UP000000539
GO	GO:0050660 GO:0010181 GO:0020037 GO:0005506 GO:0050661 GO:0004517 GO:0006809 GO:0018119
Gene3D	1.20.990.10 3.40.50.360 3.90.340.10
InterPro	IPR003097 IPR017927 IPR001094 IPR008254 IPR001709 IPR029039 IPR023173 IPR012144 IPR004030 IPR001433 IPR017938
Pfam	PF00667 PF00258 PF00175 PF02898
PIRSF	PIRSF000333
PRINTS	PR00369 PR00371
SUPFAM	SSF52218 SSF56512 SSF63380
PROSITE	PS51384 PS50902 PS60001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35228	P	Seeded From UniProt	complete
involved_in	GO:0072606	interleukin-8 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35228	P	Seeded From UniProt	complete
involved_in	GO:0072604	interleukin-6 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35228	P	Seeded From UniProt	complete
involved_in	GO:0032310	prostaglandin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35228	P	Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29477	P	Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453988 RGD:3184	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN000453992 UniProtKB:P35228	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 ZFIN:ZDB-GENE-040305-1	P	Seeded From UniProt	complete
involved_in	GO:0031284	positive regulation of guanylate cyclase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 UniProtKB:P29473 UniProtKB:P29474	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97744 PANTHER:PTN000453956 UniProtKB:Q9UHB4	F	Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C	Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002322100 RGD:3185	P	Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 ZFIN:ZDB-GENE-001101-1	P	Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P	Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3186 UniProtKB:P29475	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453956 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228 UniProtKB:Q9SB48 UniProtKB:Q9UHB4	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453765 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C	Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011676 MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P29475 UniProtKB:P35228	F	Seeded From UniProt	complete
enables	GO:0003958	NADPH-hemoprotein reductase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453763 PomBase:SPBC29A10.01 RGD:68335 SGD:S000001084 TAIR:locus:2128951 UniProtKB:A0A1D8PLR7 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:P16435 UniProtKB:Q9UBK8	F	Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	F	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F	Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	P	Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR008254 InterPro:IPR012144	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR017927 InterPro:IPR023173	F	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F	Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR004030 InterPro:IPR017927 InterPro:IPR023173 InterPro:IPR036119	P	Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.13.39	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:NOS2

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