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CHICK:NOS2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) NOS2
Protein Name(s) Nitric oxide synthase, inducible

Inducible NO synthase Inducible NOS iNOS Macrophage NOS NOS type II Peptidyl-cysteine S-nitrosylase NOS2

External Links
UniProt Q90703
EMBL U46504
U34045
D85422
RefSeq NP_990292.1
UniGene Gga.3327
ProteinModelPortal Q90703
SMR Q90703
PaxDb Q90703
PRIDE Q90703
GeneID 395807
KEGG gga:395807
CTD 4843
eggNOG COG4362
HOGENOM HOG000220884
HOVERGEN HBG000159
InParanoid Q90703
KO K13241
PhylomeDB Q90703
NextBio 20815875
PRO PR:Q90703
Proteomes UP000000539
GO GO:0050660
GO:0010181
GO:0020037
GO:0005506
GO:0050661
GO:0004517
GO:0006809
GO:0018119
Gene3D 1.20.990.10
3.40.50.360
3.90.340.10
InterPro IPR003097
IPR017927
IPR001094
IPR008254
IPR001709
IPR029039
IPR023173
IPR012144
IPR004030
IPR001433
IPR017938
Pfam PF00667
PF00258
PF00175
PF02898
PIRSF PIRSF000333
PRINTS PR00369
PR00371
SUPFAM SSF52218
SSF56512
SSF63380
PROSITE PS51384
PS50902
PS60001

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1900015

regulation of cytokine production involved in inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35228

P

Seeded From UniProt

complete

involved_in

GO:0072606

interleukin-8 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35228

P

Seeded From UniProt

complete

involved_in

GO:0072604

interleukin-6 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35228

P

Seeded From UniProt

complete

involved_in

GO:0032310

prostaglandin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35228

P

Seeded From UniProt

complete

involved_in

GO:0018119

peptidyl-cysteine S-nitrosylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P29477

P

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10191
MGI:MGI:97361
PANTHER:PTN000453956
RGD:3184
RGD:68335
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:Q9UBK8
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

involved_in

GO:0045776

negative regulation of blood pressure

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453988
RGD:3184

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97361
PANTHER:PTN000453992
UniProtKB:P35228

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97361
PANTHER:PTN001066032
RGD:3184
RGD:3185
RGD:3186
ZFIN:ZDB-GENE-040305-1

P

Seeded From UniProt

complete

involved_in

GO:0031284

positive regulation of guanylate cyclase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001066032
UniProtKB:P29473
UniProtKB:P29474

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97744
PANTHER:PTN000453956
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

part_of

GO:0012506

vesicle membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001066032
RGD:3184
RGD:3185
RGD:3186

C

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10191
MGI:MGI:97361
PANTHER:PTN000453956
RGD:3184
RGD:68335
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:Q9UBK8
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002322100
RGD:3185

P

Seeded From UniProt

complete

involved_in

GO:0007263

nitric oxide mediated signal transduction

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001066032
RGD:3184
ZFIN:ZDB-GENE-001101-1

P

Seeded From UniProt

complete

involved_in

GO:0006809

nitric oxide biosynthetic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97360
MGI:MGI:97361
MGI:MGI:97362
PANTHER:PTN001066032
RGD:3184
RGD:3185
RGD:3186
UniProtKB:P29473
UniProtKB:P29474
UniProtKB:P35228

P

Seeded From UniProt

complete

involved_in

GO:0006527

arginine catabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97361
PANTHER:PTN001066032
RGD:3184
UniProtKB:P29473
UniProtKB:P29474
UniProtKB:P35228

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001066032
RGD:3184
RGD:3186
UniProtKB:P29475

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453956
RGD:3184
RGD:3185
RGD:3186
UniProtKB:P35228
UniProtKB:Q9SB48
UniProtKB:Q9UHB4

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453765
RGD:3184
RGD:3185
RGD:3186
UniProtKB:P35228

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97362
PANTHER:PTN001066032
RGD:3184
RGD:3185
RGD:3186

C

Seeded From UniProt

complete

enables

GO:0004517

nitric-oxide synthase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011676
MGI:MGI:97360
MGI:MGI:97361
MGI:MGI:97362
PANTHER:PTN001066032
RGD:3184
RGD:3185
RGD:3186
UniProtKB:P29473
UniProtKB:P29474
UniProtKB:P29475
UniProtKB:P35228

F

Seeded From UniProt

complete

enables

GO:0003958

NADPH-hemoprotein reductase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453763
PomBase:SPBC29A10.01
RGD:68335
SGD:S000001084
TAIR:locus:2128951
UniProtKB:A0A1D8PLR7
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:P16435
UniProtKB:Q9UBK8

F

Seeded From UniProt

complete

enables

GO:0004517

nitric-oxide synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004030
InterPro:IPR012144
InterPro:IPR036119

F

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012144

F

Seeded From UniProt

complete

involved_in

GO:0006809

nitric oxide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004030
InterPro:IPR012144
InterPro:IPR036119

P

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001094
InterPro:IPR008254
InterPro:IPR012144

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001433
InterPro:IPR001709
InterPro:IPR003097
InterPro:IPR017927
InterPro:IPR023173

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012144

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012144

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012144

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001094
InterPro:IPR001433
InterPro:IPR001709
InterPro:IPR003097
InterPro:IPR004030
InterPro:IPR017927
InterPro:IPR023173
InterPro:IPR036119

P

Seeded From UniProt

complete

enables

GO:0004517

nitric-oxide synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.13.39

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page