CHICK:MIF

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	MIF
Protein Name(s)	Macrophage migration inhibitory factor MIF L-dopachrome isomerase L-dopachrome tautomerase Phenylpyruvate tautomerase
External Links
UniProt	Q02960
EMBL	M95776
PIR	C47274
RefSeq	XP_003642282.1
UniGene	Gga.3585
ProteinModelPortal	Q02960
SMR	Q02960
STRING	9031.ENSGALP00000010214
PaxDb	Q02960
PRIDE	Q02960
Ensembl	ENSGALT00000010228
GeneID	100857237
KEGG	gga:100857237
CTD	4282
eggNOG	NOG08790
GeneTree	ENSGT00730000111101
HOGENOM	HOG000112325
HOVERGEN	HBG003240
InParanoid	Q02960
KO	K07253
OMA	MGKPAQY
OrthoDB	EOG7GXPDN
PhylomeDB	Q02960
TreeFam	TF313853
PRO	PR:Q02960
Proteomes	UP000000539
GO	GO:0009986 GO:0005737 GO:0005615 GO:0070062 GO:0042056 GO:0004167 GO:0050178 GO:0007569 GO:0008283 GO:0007166 GO:0030330 GO:0006954 GO:0045087 GO:0090344 GO:0071157 GO:0032269 GO:0043518 GO:0010629 GO:1902166 GO:0002906 GO:0033033 GO:0090238 GO:0030890 GO:2000343 GO:0050715 GO:0070374 GO:0048146 GO:0031666 GO:0043406 GO:0061081 GO:0033138 GO:0050731 GO:0061078 GO:0010739 GO:0001516 GO:0070207
InterPro	IPR001398 IPR019829 IPR014347
PANTHER	PTHR11954
Pfam	PF01187
ProDom	PD004816
SUPFAM	SSF55331
PROSITE	PS01158

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0042289	MHC class II protein binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:I4AY87 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:I4AY87 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0019752	carboxylic acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0010760	negative regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0010739	positive regulation of protein kinase A signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	C		Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
enables	GO:0004167	dopachrome isomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	F		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14174 ensembl:ENSP00000215754	P		Seeded From UniProt	complete
involved_in	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0090238	positive regulation of arachidonic acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0061078	positive regulation of prostaglandin secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	F		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0033033	negative regulation of myeloid cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0032269	negative regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	F		Seeded From UniProt	complete
involved_in	GO:0002906	negative regulation of mature B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
enables	GO:0004167	dopachrome isomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.3.3.12	F		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.3.2.1	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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References

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