CHICK:KSYK

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SYK
Protein Name(s)	Tyrosine-protein kinase SYK
External Links
UniProt	F1N9Y5
EMBL	AJ720543 AADN02069860 AADN02069861 AADN02069862 AADN02069863 AADN02069864 AADN02069865 AADN02069866 AADN02069867 AADN02069868 AADN02069869
RefSeq	NP_001026601.1
UniGene	Gga.22529
ProteinModelPortal	F1N9Y5
STRING	9031.ENSGALP00000032170
Ensembl	ENSGALT00000032807
GeneID	427272
KEGG	gga:427272
CTD	6850
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000113264
HOVERGEN	HBG001540
InParanoid	F1N9Y5
KO	K05855
OrthoDB	EOG7MWGWD
Reactome	REACT_189761 REACT_194994 REACT_197606 REACT_230602 REACT_236561 REACT_257604
NextBio	20828556
PRO	PR:F1N9Y5
Proteomes	UP000000539
GO	GO:0005829 GO:0032009 GO:0005886 GO:0005524 GO:0004715 GO:0002250 GO:0050853 GO:0048514 GO:0071226 GO:0042742 GO:0045087 GO:0007229 GO:0035556 GO:0002366 GO:0007159 GO:0001945 GO:0002281 GO:0002283 GO:0030593 GO:0018108 GO:0045780 GO:0033630 GO:0006468 GO:0090237 GO:0070372 GO:0043313 GO:0050764 GO:0010543 GO:0090330 GO:0032928 GO:0002554
Gene3D	1.10.930.10 3.30.505.10
InterPro	IPR011009 IPR023420 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR012234
Pfam	PF07714 PF00017
PIRSF	PIRSF000604
PRINTS	PR00401 PR00109
SMART	SM00252 SM00219
SUPFAM	SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:11434777^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11434777^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11434777^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0090237	regulation of arachidonic acid secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0071226	cellular response to molecule of fungal origin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:9697839^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050764	regulation of phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0043313	regulation of neutrophil degranulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0032928	regulation of superoxide anion generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	C	Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43405	P	Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0007159	leukocyte cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43405	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9697839^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:9697839^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002554	serotonin secretion by platelet	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0002366	leukocyte activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:9697839^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P	Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P	Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 UniProtKB:F1N9Y5	P	Seeded From UniProt	complete
involved_in	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P	Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 UniProtKB:P43405	P	Seeded From UniProt	complete
involved_in	GO:0043306	positive regulation of mast cell degranulation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 RGD:3796	P	Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P	Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P	Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700479 UniProtKB:F1N9Y5	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234 InterPro:IPR023420	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR012234 InterPro:IPR017441	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR012234 InterPro:IPR020635	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-GGA-9607039	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qin, S & Chock, PB (2001) Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling. Biochemistry 40 8085-91 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Fu, C et al. (1998) BLNK: a central linker protein in B cell activation. Immunity 9 93-103 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11434777-1] 1.0 ^1.1 ^1.2 Qin, S & Chock, PB (2001) Bruton's tyrosine kinase is essential for hydrogen peroxide-induced calcium signaling. Biochemistry 40 8085-91 PubMed GONUTS page

[PMID:9697839-2] 2.0 ^2.1 ^2.2 ^2.3 Fu, C et al. (1998) BLNK: a central linker protein in B cell activation. Immunity 9 93-103 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:KSYK

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