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CHICK:IHH
Contents
Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
Gene Name(s) | IHH | |
Protein Name(s) | Indian hedgehog protein
IHH Indian hedgehog protein N-product Indian hedgehog protein C-product | |
External Links | ||
UniProt | Q98938 | |
EMBL | U58511 | |
RefSeq | NP_990288.1 | |
UniGene | Gga.473 | |
ProteinModelPortal | Q98938 | |
SMR | Q98938 | |
STRING | 9031.ENSGALP00000018493 | |
MEROPS | C46.003 | |
PaxDb | Q98938 | |
GeneID | 395801 | |
KEGG | gga:395801 | |
CTD | 3549 | |
eggNOG | NOG250647 | |
HOGENOM | HOG000233428 | |
HOVERGEN | HBG005480 | |
InParanoid | Q98938 | |
KO | K11989 | |
PhylomeDB | Q98938 | |
NextBio | 20815869 | |
PRO | PR:Q98938 | |
Proteomes | UP000000539 | |
GO | GO:0005615 GO:0005886 GO:0046872 GO:0008233 GO:0051216 GO:0007267 | |
Gene3D | 2.170.16.10 3.30.1380.10 | |
InterPro | IPR001657 IPR028992 IPR009045 IPR000320 IPR001767 IPR003586 IPR003587 | |
Pfam | PF01085 PF01079 | |
PIRSF | PIRSF009400 | |
PRINTS | PR00632 | |
SMART | SM00305 SM00306 | |
SUPFAM | SSF51294 SSF55166 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:1903042 |
negative regulation of chondrocyte hypertrophy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902738 |
regulation of chondrocyte differentiation involved in endochondral bone morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0002222) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902733 |
regulation of growth plate cartilage chondrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060591 |
chondroblast differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045669 |
positive regulation of osteoblast differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032331 |
negative regulation of chondrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0010328) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030166 |
proteoglycan biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010770 |
positive regulation of cell morphogenesis involved in differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010694 |
positive regulation of alkaline phosphatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0010328) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010694 |
positive regulation of alkaline phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001049) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007228 |
positive regulation of hh target transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003420 |
regulation of growth plate cartilage chondrocyte proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051216 |
cartilage development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090136 |
epithelial cell-cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072498 |
embryonic skeletal joint development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061053 |
somite development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060323 |
head morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060220 |
camera-type eye photoreceptor cell fate commitment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051216 |
cartilage development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048745 |
smooth muscle tissue development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048666 |
neuron development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048596 |
embryonic camera-type eye morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048557 |
embryonic digestive tract morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048469 |
cell maturation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048074 |
negative regulation of eye pigmentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046639 |
negative regulation of alpha-beta T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045880 |
positive regulation of smoothened signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045596 |
negative regulation of cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045453 |
bone resorption |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043010 |
camera-type eye development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0040008 |
regulation of growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035988 |
chondrocyte proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035264 |
multicellular organism growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033089 |
positive regulation of T cell differentiation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033088 |
negative regulation of immature T cell proliferation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033085 |
negative regulation of T cell differentiation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032967 |
positive regulation of collagen biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031016 |
pancreas development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030704 |
vitelline membrane formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009880 |
embryonic pattern specification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007389 |
pattern specification process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007224 |
smoothened signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006029 |
proteoglycan metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005113 |
patched binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003413 |
chondrocyte differentiation involved in endochondral bone morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003406 |
retinal pigment epithelium development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003382 |
epithelial cell morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001947 |
heart looping |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001944 |
vasculature development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001763 |
morphogenesis of a branching structure |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001708 |
cell fate specification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001649 |
osteoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001569 |
branching involved in blood vessel morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001503 |
ossification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001501 |
skeletal system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007224 |
smoothened signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14623 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14623 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005509 |
calcium ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14623 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005113 |
patched binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14623 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001501 |
skeletal system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14623 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008233 |
peptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051216 |
cartilage development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q14623:PRO_0000013230 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
UniProtKB:Q14623:PRO_0000013230 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035988 |
chondrocyte proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ma, RS et al. (2013) The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 166 117-22 PubMed GONUTS page
- ↑ Vortkamp, A et al. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273 613-22 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Enomoto-Iwamoto, M et al. (2000) Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation. J. Bone Miner. Res. 15 1659-68 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Nakamura, T et al. (1997) Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun. 237 465-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gao, B et al. (2009) A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458 1196-200 PubMed GONUTS page
- ↑ Zhang, D et al. (2003) ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J. Bone Miner. Res. 18 1593-604 PubMed GONUTS page
- ↑ Shimo, T et al. (2004) Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis. Dev. Dyn. 229 607-17 PubMed GONUTS page
c
- GO:0005509 ! calcium ion binding
- GO:0060220 ! camera-type eye photoreceptor cell fate commitment
- GO:0043010 ! camera-type eye development
- GO:0051216 ! cartilage development
- GO:0007267 ! cell-cell signaling
- GO:0030154 ! cell differentiation
- GO:0001708 ! cell fate specification
- GO:0048469 ! cell maturation
- GO:0060591 ! chondroblast differentiation
- GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
- GO:0035988 ! chondrocyte proliferation
- Chordata
- Coelurosauria
- Craniata
e
- GO:0048596 ! embryonic camera-type eye morphogenesis
- GO:0042733 ! embryonic digit morphogenesis
- GO:0048557 ! embryonic digestive tract morphogenesis
- GO:0009880 ! embryonic pattern specification
- GO:0072498 ! embryonic skeletal joint development
- GO:0003382 ! epithelial cell morphogenesis
- GO:0090136 ! epithelial cell-cell adhesion
- Eukaryota
- Euteleostomi
- GO:0031012 ! extracellular matrix
- GO:0005615 ! extracellular space
- GO:0005576 ! extracellular region
m
n
- GO:1903042 ! negative regulation of chondrocyte hypertrophy
- GO:0033085 ! negative regulation of T cell differentiation in thymus
- GO:0046639 ! negative regulation of alpha-beta T cell differentiation
- GO:0045596 ! negative regulation of cell differentiation
- GO:0048074 ! negative regulation of eye pigmentation
- GO:0032331 ! negative regulation of chondrocyte differentiation
- GO:0033088 ! negative regulation of immature T cell proliferation in thymus
- Neognathae
- GO:0048666 ! neuron development
o
p
- GO:0031016 ! pancreas development
- GO:0005113 ! patched binding
- GO:0007389 ! pattern specification process
- GO:0008233 ! peptidase activity
- Phasianidae
- Phasianinae
- GO:0005886 ! plasma membrane
- GO:0010628 ! positive regulation of gene expression
- GO:0046638 ! positive regulation of alpha-beta T cell differentiation
- GO:0010694 ! positive regulation of alkaline phosphatase activity
- GO:0010770 ! positive regulation of cell morphogenesis
- GO:0045669 ! positive regulation of osteoblast differentiation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0033089 ! positive regulation of T cell differentiation in thymus
- GO:0002053 ! positive regulation of mesenchymal cell proliferation
- GO:0032967 ! positive regulation of collagen biosynthetic process
- GO:0045880 ! positive regulation of smoothened signaling pathway
- GO:0006029 ! proteoglycan metabolic process
- GO:0030166 ! proteoglycan biosynthetic process
- GO:0006508 ! proteolysis
r
- GO:1902733 ! regulation of growth plate cartilage chondrocyte differentiation
- GO:1902738 ! regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
- GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation
- GO:0040008 ! regulation of growth
- GO:0003406 ! retinal pigment epithelium development
s