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CHICK:IHH

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) IHH
Protein Name(s) Indian hedgehog protein

IHH Indian hedgehog protein N-product Indian hedgehog protein C-product

External Links
UniProt Q98938
EMBL U58511
RefSeq NP_990288.1
UniGene Gga.473
ProteinModelPortal Q98938
SMR Q98938
STRING 9031.ENSGALP00000018493
MEROPS C46.003
PaxDb Q98938
GeneID 395801
KEGG gga:395801
CTD 3549
eggNOG NOG250647
HOGENOM HOG000233428
HOVERGEN HBG005480
InParanoid Q98938
KO K11989
PhylomeDB Q98938
NextBio 20815869
PRO PR:Q98938
Proteomes UP000000539
GO GO:0005615
GO:0005886
GO:0046872
GO:0008233
GO:0051216
GO:0007267
Gene3D 2.170.16.10
3.30.1380.10
InterPro IPR001657
IPR028992
IPR009045
IPR000320
IPR001767
IPR003586
IPR003587
Pfam PF01085
PF01079
PIRSF PIRSF009400
PRINTS PR00632
SMART SM00305
SM00306
SUPFAM SSF51294
SSF55166

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1903042

negative regulation of chondrocyte hypertrophy

PMID:23928032[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902738

regulation of chondrocyte differentiation involved in endochondral bone morphogenesis

PMID:8662546[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002222)

Seeded From UniProt

complete

involved_in

GO:1902733

regulation of growth plate cartilage chondrocyte differentiation

PMID:23928032[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060591

chondroblast differentiation

PMID:10976986[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

PMID:9268735[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032331

negative regulation of chondrocyte differentiation

PMID:19252479[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0010328)

Seeded From UniProt

complete

involved_in

GO:0030166

proteoglycan biosynthetic process

PMID:10976986[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010770

positive regulation of cell morphogenesis involved in differentiation

PMID:10976986[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010694

positive regulation of alkaline phosphatase activity

PMID:19252479[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0010328)

Seeded From UniProt

complete

involved_in

GO:0010694

positive regulation of alkaline phosphatase activity

PMID:9268735[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:19252479[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001049)

Seeded From UniProt

complete

involved_in

GO:0007228

positive regulation of hh target transcription factor activity

PMID:23928032[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:10976986[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:9268735[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0003420

regulation of growth plate cartilage chondrocyte proliferation

PMID:23928032[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:12968668[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090136

epithelial cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0072498

embryonic skeletal joint development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0060323

head morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0060220

camera-type eye photoreceptor cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0048745

smooth muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0048666

neuron development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0048596

embryonic camera-type eye morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0048557

embryonic digestive tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0048469

cell maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0048074

negative regulation of eye pigmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0046639

negative regulation of alpha-beta T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0046638

positive regulation of alpha-beta T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0045596

negative regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0045453

bone resorption

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0043010

camera-type eye development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0042733

embryonic digit morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0040008

regulation of growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0035988

chondrocyte proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0035264

multicellular organism growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0033089

positive regulation of T cell differentiation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0033088

negative regulation of immature T cell proliferation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0033085

negative regulation of T cell differentiation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0031016

pancreas development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

C

Seeded From UniProt

complete

involved_in

GO:0030704

vitelline membrane formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0009880

embryonic pattern specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0006029

proteoglycan metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

enables

GO:0005113

patched binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

F

Seeded From UniProt

complete

involved_in

GO:0003413

chondrocyte differentiation involved in endochondral bone morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0003406

retinal pigment epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0003382

epithelial cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001944

vasculature development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001763

morphogenesis of a branching structure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001708

cell fate specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001569

branching involved in blood vessel morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97812
ensembl:ENSMUSP00000128056

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14623
ensembl:ENSP00000295731

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14623
ensembl:ENSP00000295731

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14623
ensembl:ENSP00000295731

F

Seeded From UniProt

complete

enables

GO:0005113

patched binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14623
ensembl:ENSP00000295731

F

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14623
ensembl:ENSP00000295731

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001767

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000320
InterPro:IPR001657

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001657

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001767

F

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14623:PRO_0000013230

P

Seeded From UniProt

complete

involved_in

GO:0042733

embryonic digit morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14623:PRO_0000013230

P

Seeded From UniProt

complete

involved_in

GO:0035988

chondrocyte proliferation

PMID:14991716[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Ma, RS et al. (2013) The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 166 117-22 PubMed GONUTS page
  2. Vortkamp, A et al. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273 613-22 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Enomoto-Iwamoto, M et al. (2000) Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation. J. Bone Miner. Res. 15 1659-68 PubMed GONUTS page
  4. 4.0 4.1 4.2 Nakamura, T et al. (1997) Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun. 237 465-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 Gao, B et al. (2009) A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458 1196-200 PubMed GONUTS page
  6. Zhang, D et al. (2003) ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J. Bone Miner. Res. 18 1593-604 PubMed GONUTS page
  7. Shimo, T et al. (2004) Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis. Dev. Dyn. 229 607-17 PubMed GONUTS page