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PMID:12968668

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Citation

Zhang, D, Schwarz, EM, Rosier, RN, Zuscik, MJ, Puzas, JE and O'Keefe, RJ (2003) ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J. Bone Miner. Res. 18:1593-604

Abstract

Growth plate chondrocytes integrate multiple signals during normal development. The type I BMP receptor ALK2 is expressed in cartilage and expression of constitutively active (CA) ALK2 and other activated type I BMP receptors results in maturation-independent expression of Ihh in chondrocytes in vitro and in vivo. The findings suggest that BMP signaling modulates the Ihh/PTHrP signaling pathway that regulates the rate of chondrocyte differentiation.

Links

PubMed Online version:10.1359/jbmr.2003.18.9.1593

Keywords

Activin Receptors, Type I/genetics; Activin Receptors, Type I/metabolism; Animals; Animals, Genetically Modified; Base Sequence; Bone Development/genetics; Bone Development/physiology; Bone Morphogenetic Protein Receptors, Type I; Cartilage/abnormalities; Cartilage/embryology; Cartilage/metabolism; Cell Differentiation; Cells, Cultured; Chick Embryo; Chondrocytes/cytology; Chondrocytes/metabolism; Chondrogenesis; DNA, Complementary/genetics; Gene Expression Regulation, Developmental; Hedgehog Proteins; In Situ Hybridization; Parathyroid Hormone-Related Protein/metabolism; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Proteins; Receptors, Growth Factor/genetics; Receptors, Growth Factor/metabolism; Receptors, Transforming Growth Factor beta/genetics; Receptors, Transforming Growth Factor beta/metabolism; Signal Transduction; Trans-Activators/biosynthesis; Trans-Activators/genetics; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:ACVR1

involved_in

GO:0007179: transforming growth factor beta receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ACVR1

involved_in

GO:0048641: regulation of skeletal muscle tissue development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:ACVR1

enables

GO:0048185: activin binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

CHICK:ACVR1

enables

GO:0050431: transforming growth factor beta binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

CHICK:ACVR1

involved_in

GO:0030513: positive regulation of BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:IHH

involved_in

GO:0051216: cartilage development

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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