CHICK:HME2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	EN2 (synonyms: EN-2)
Protein Name(s)	Homeobox protein engrailed-2 Gg-En-2 Homeobox protein en-2
External Links
UniProt	Q05917
EMBL	L12696 L12697
PIR	F48423
RefSeq	NP_001254648.1
UniGene	Gga.56328
PDB	3ZOB
PDBsum	3ZOB
Ensembl	ENSGALT00000038721
GeneID	100859435
KEGG	gga:100859435
CTD	2020
GeneTree	ENSGT00780000121984
HOVERGEN	HBG005975
InParanoid	Q05917
KO	K09319
OMA	PHPHRIT
PRO	PR:Q05917
Proteomes	UP000000539
GO	GO:0030175 GO:0030426 GO:0030027 GO:0043005 GO:0005634 GO:0043565 GO:0007411 GO:0030902 GO:0030901 GO:0042327 GO:0045944 GO:0045727
Gene3D	1.10.10.60
InterPro	IPR019549 IPR017970 IPR001356 IPR020479 IPR009057 IPR000747 IPR019737 IPR000047
Pfam	PF10525 PF00046
PRINTS	PR00026 PR00024 PR00031
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00033 PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901215	negative regulation of neuron death	PMID:17267560^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09065	P	regulates_o_occurs_in:(CL:0000700) regulates_o_occurs_in:(UBERON:0001891) regulates_o_occurs_in:(UBERON:0007023)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:12490552^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0001945)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:10772799^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001895)\|part_of:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:16267555^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000577 MGI:MGI:95389 MGI:MGI:95390 PANTHER:PTN000678674 PomBase:SPAC1F3.07c UniProtKB:Q05925 WB:WBGene00000439	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000577 PANTHER:PTN000678674 PomBase:SPAC1F3.07c RGD:1561842 SGD:S000004023 UniProtKB:A0A0G2JT82 UniProtKB:P19622 UniProtKB:Q05925 WB:WBGene00000439	C		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000577 PANTHER:PTN000678674 UniProtKB:Q05925 WB:WBGene00000439	F		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000577 MGI:MGI:95389 MGI:MGI:95390 PANTHER:PTN000678675 UniProtKB:Q05917 ZFIN:ZDB-GENE-980526-167 ZFIN:ZDB-GENE-980526-216 ZFIN:ZDB-GENE-980526-6	P		Seeded From UniProt	complete
part_of	GO:0016586	RSC-type complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000678674 PomBase:SPAC1F3.07c SGD:S000004023	C		Seeded From UniProt	complete
involved_in	GO:1990403	embryonic brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09066 ensembl:ENSMUSP00000036761	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19622 ensembl:ENSP00000297375	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19622 ensembl:ENSP00000297375	C		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19622 ensembl:ENSP00000297375	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000047 InterPro:IPR000747 InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR020479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000747	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000747	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sonnier, L et al. (2007) Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. J. Neurosci. 27 1063-71 PubMed GONUTS page
↑ Sugiyama, S & Nakamura, H (2003) The role of Grg4 in tectal laminar formation. Development 130 451-62 PubMed GONUTS page
↑ Sugiyama, S et al. (2000) Antagonizing activity of chick Grg4 against tectum-organizing activity. Dev. Biol. 221 168-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Brunet, I et al. (2005) The transcription factor Engrailed-2 guides retinal axons. Nature 438 94-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17267560-1] Sonnier, L et al. (2007) Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. J. Neurosci. 27 1063-71 PubMed GONUTS page

[PMID:12490552-2] Sugiyama, S & Nakamura, H (2003) The role of Grg4 in tectal laminar formation. Development 130 451-62 PubMed GONUTS page

[PMID:10772799-3] Sugiyama, S et al. (2000) Antagonizing activity of chick Grg4 against tectum-organizing activity. Dev. Biol. 221 168-80 PubMed GONUTS page

[PMID:16267555-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Brunet, I et al. (2005) The transcription factor Engrailed-2 guides retinal axons. Nature 438 94-8 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:HME2

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