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CHICK:FGF2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) FGF2
Protein Name(s) Fibroblast growth factor 2

FGF-2 Basic fibroblast growth factor bFGF Heparin-binding growth factor 2 HBGF-2

External Links
UniProt P48800
EMBL M95707
RefSeq NP_990764.1
UniGene Gga.39646
ProteinModelPortal P48800
SMR P48800
PaxDb P48800
Ensembl ENSGALT00000032155
GeneID 396413
KEGG gga:396413
CTD 2247
eggNOG NOG325757
GeneTree ENSGT00730000110923
HOGENOM HOG000236341
HOVERGEN HBG007580
InParanoid P48800
KO K18497
OMA FFLRINP
PhylomeDB P48800
Reactome REACT_284939
REACT_290454
REACT_301570
REACT_310443
REACT_333432
REACT_334452
REACT_338659
REACT_344129
REACT_347570
REACT_357371
REACT_357752
REACT_357807
REACT_358139
REACT_358141
REACT_358606
REACT_359074
REACT_359115
REACT_359511
REACT_360043
REACT_360791
REACT_361093
REACT_361101
REACT_361309
REACT_361442
REACT_361837
REACT_361899
REACT_362200
REACT_362215
REACT_362397
NextBio 20816454
PRO PR:P48800
Proteomes UP000000539
ExpressionAtlas P48800
GO GO:0005829
GO:0005615
GO:0005730
GO:0005634
GO:0008201
GO:0001525
GO:0007420
GO:0030154
GO:0051301
GO:0008283
GO:0003347
GO:0008543
GO:0014843
GO:0070660
GO:0002089
GO:0001707
GO:0072248
GO:0003407
GO:0060563
GO:0022008
GO:0045766
GO:0051781
GO:0010756
GO:0072089
GO:0001894
GO:0042060
InterPro IPR008996
IPR028223
IPR002209
IPR028142
PANTHER PTHR11486
PTHR11486:SF68
PRINTS PR00263
PR00262
SMART SM00442
SUPFAM SSF50353
PROSITE PS00247

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0014843

growth factor dependent regulation of skeletal muscle satellite cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09038

P

Seeded From UniProt

complete

involved_in

GO:0014843

growth factor dependent regulation of skeletal muscle satellite cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A0A087WUF6

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09038

P

Seeded From UniProt

complete

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09038

P

Seeded From UniProt

complete

involved_in

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09038

P

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09038

F

Seeded From UniProt

complete

involved_in

GO:0072248

metanephric glomerular visceral epithelial cell differentiation

PMID:8200474[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072089

stem cell proliferation

PMID:16916506[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002346)

Seeded From UniProt

complete

involved_in

GO:0070660

inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration

PMID:8789806[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060563

neuroepithelial cell differentiation

PMID:16916506[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

PMID:16916506[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002346)

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:7601314[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

PMID:8789806[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

occurs_in:(UBERON:0000970)

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:8789806[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

occurs_in:(UBERON:0010312)

Seeded From UniProt

complete

involved_in

GO:0022008

neurogenesis

PMID:16916506[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010756

positive regulation of plasminogen activation

PMID:7601314[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:3186711[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0030326)

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:8789806[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

occurs_in:(UBERON:0010312)

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:1647988[6]

ECO:0000353

physical interaction evidence used in manual assertion

CHEBI:28304

F

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:3186711[5]

ECO:0000353

physical interaction evidence used in manual assertion

CHEBI:28304

F

part_of:(GO:0030326)

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:7601314[4]

ECO:0000353

physical interaction evidence used in manual assertion

CHEBI:28304

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:16916506[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:1647988[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:2022692[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000187)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:7748784[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0004341)
  • part_of:(UBERON:0002532)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:8200474[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000080)
  • part_of:(UBERON:0004347)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:8789806[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000045)
  • part_of:(CL:0000561)
  • part_of:(UBERON:0001795)
  • part_of:(UBERON:0001790)

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:8789806[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0013731)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7748784[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000089)
  • part_of:(UBERON:0000090)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8200474[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000653)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8789806[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0013731)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16916506[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:7748784[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002089

lens morphogenesis in camera-type eye

PMID:8789806[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001894

tissue homeostasis

PMID:8789806[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

occurs_in:(UBERON:0000970)

Seeded From UniProt

complete

involved_in

GO:0001707

mesoderm formation

PMID:1647988[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0090263

positive regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0060129

thyroid-stimulating hormone-secreting cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0060128

corticotropin hormone secreting cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0048864

stem cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0046668

regulation of retinal cell programmed cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0045597

positive regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0021940

positive regulation of cerebellar granule cell precursor proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0021762

substantia nigra development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0010001

glial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

C

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0001759

organ induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15655
ensembl:ENSMUSP00000143094

P

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028223

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028223

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002209

F

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028223

P

Seeded From UniProt

complete

involved_in

GO:0003347

epicardial cell to mesenchymal cell transition

PMID:20299672[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003407

neural retina development

PMID:15901663[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Dono, R & Zeller, R (1994) Cell-type-specific nuclear translocation of fibroblast growth factor-2 isoforms during chicken kidney and limb morphogenesis. Dev. Biol. 163 316-30 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Martín, C et al. (2006) FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells. Dev. Biol. 297 402-16 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Lee, KH & Cotanche, DA (1996) Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells. Hear. Res. 94 1-13 PubMed GONUTS page
  4. 4.0 4.1 4.2 Ribatti, D et al. (1995) Endogenous basic fibroblast growth factor is implicated in the vascularization of the chick embryo chorioallantoic membrane. Dev. Biol. 170 39-49 PubMed GONUTS page
  5. 5.0 5.1 Munaim, SI et al. (1988) Developmental changes in fibroblast growth factor in the chicken embryo limb bud. Proc. Natl. Acad. Sci. U.S.A. 85 8091-3 PubMed GONUTS page
  6. 6.0 6.1 6.2 Parlow, MH et al. (1991) Localization of bFGF-like proteins as punctate inclusions in the preseptation myocardium of the chicken embryo. Dev. Biol. 146 139-47 PubMed GONUTS page
  7. Consigli, SA & Joseph-Silverstein, J (1991) Immunolocalization of basic fibroblast growth factor during chicken cardiac development. J. Cell. Physiol. 146 379-85 PubMed GONUTS page
  8. 8.0 8.1 8.2 Riese, J et al. (1995) Nucleo-cytoplasmic translocation and secretion of fibroblast growth factor-2 during avian gastrulation. Mech. Dev. 49 13-22 PubMed GONUTS page
  9. Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page
  10. Kubo, F et al. (2005) Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. Development 132 2759-70 PubMed GONUTS page