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CHICK:ESR1

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) ESR1 (synonyms: ESR, NR3A1)
Protein Name(s) Estrogen receptor

ER ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1

External Links
UniProt P06212
EMBL X03805
PIR A40914
RefSeq NP_990514.1
UniGene Gga.650
ProteinModelPortal P06212
SMR P06212
STRING 9031.ENSGALP00000021137
PaxDb P06212
GeneID 396099
KEGG gga:396099
CTD 2099
eggNOG NOG320746
HOGENOM HOG000233468
HOVERGEN HBG108344
InParanoid P06212
KO K08550
PhylomeDB P06212
NextBio 20816157
PRO PR:P06212
Proteomes UP000000539
GO GO:0005634
GO:0030284
GO:0043565
GO:0003700
GO:0005496
GO:0008270
GO:0010628
GO:0006351
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR008946
IPR000536
IPR024178
IPR001292
IPR024736
IPR001723
IPR001628
IPR013088
Pfam PF12743
PF00104
PF02159
PF00105
PIRSF PIRSF500101
PIRSF002527
PRINTS PR00543
PR00398
PR00047
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010628

positive regulation of gene expression

PMID:21047992[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030284

estrogen receptor activity

PMID:21047992[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24704443[2]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002119)
  • part_of:(UBERON:0001304)
  • part_of:(UBERON:0003981)
  • part_of:(UBERON:0005170)|part_of:(UBERON:0002118)
  • part_of:(CL:0000066)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8832390[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8832390[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051879

Hsp90 protein binding

PMID:8832390[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11501

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06211

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001292
InterPro:IPR001723
InterPro:IPR024178

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723
InterPro:IPR024178

F

Seeded From UniProt

complete

enables

GO:0005496

steroid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001292
InterPro:IPR024178

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001292
InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR024178

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001292
InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR013088
InterPro:IPR024178

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR013088
InterPro:IPR024178

F

Seeded From UniProt

complete

enables

GO:0030284

estrogen receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001292

F

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001292

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0005496

steroid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0754

F

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Lee, JS et al. (2011) Molecular and functional characterization of Aryl hydrocarbon receptor repressor from the chicken (Gallus gallus): interspecies similarities and differences. Toxicol. Sci. 119 319-34 PubMed GONUTS page
  2. González-Morán, MG (2014) Changes in the cellular localization of estrogen receptor alpha in the growing and regressing ovaries of Gallus domesticus during development. Biochem. Biophys. Res. Commun. 447 197-204 PubMed GONUTS page
  3. 3.0 3.1 3.2 Meng, X et al. (1996) Mutational analysis of Hsp90 alpha dimerization and subcellular localization: dimer disruption does not impede "in vivo' interaction with estrogen receptor. J. Cell. Sci. 109 ( Pt 7) 1677-87 PubMed GONUTS page