CHICK:DYR

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	DHFR
Protein Name(s)	Dihydrofolate reductase
External Links
UniProt	P00378
PIR	A00390
UniGene	Gga.2883 Gga.48831
PDB	1DR1 1DR2 1DR3 1DR4 1DR5 1DR6 1DR7 8DFR
PDBsum	1DR1 1DR2 1DR3 1DR4 1DR5 1DR6 1DR7 8DFR
ProteinModelPortal	P00378
SMR	P00378
STRING	9031.ENSGALP00000025076
BindingDB	P00378
ChEMBL	CHEMBL2575
PaxDb	P00378
eggNOG	COG0262
HOVERGEN	HBG000773
InParanoid	P00378
BRENDA	1.5.1.3
UniPathway	UPA00077
EvolutionaryTrace	P00378
PRO	PR:P00378
Proteomes	UP000000539
GO	GO:0004146 GO:0008144 GO:0003729 GO:0050661 GO:0006545 GO:0009165 GO:0006730 GO:0031427 GO:0046654 GO:0046653
Gene3D	3.40.430.10
InterPro	IPR012259 IPR024072 IPR017925 IPR001796
Pfam	PF00186
PRINTS	PR00070
SUPFAM	SSF53597
PROSITE	PS00075 PS51330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0046653	tetrahydrofolate metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00374	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00374	F		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00374	F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00374	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500	F		Seeded From UniProt	complete
involved_in	GO:0046655	folic acid metabolic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500 ZFIN:ZDB-GENE-010406-5	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500 UniProtKB:P00374 UniProtKB:P9WNX1	P		Seeded From UniProt	complete
involved_in	GO:0046452	dihydrofolate metabolic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000167322 RGD:2500 UniProtKB:P00374	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94890 PANTHER:PTN000556119 RGD:2500 UniProtKB:P00374 UniProtKB:Q86XF0	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94890 PANTHER:PTN000167328 RGD:2500 UniProtKB:P00374 UniProtKB:Q86XF0	C		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10326 FB:FBgn0004087 MGI:MGI:94890 PANTHER:PTN000167322 PomBase:SPCC1223.08c RGD:2500 UniProtKB:P00374 UniProtKB:P9WNX1 UniProtKB:Q86XF0 dictyBase:DDB_G0286755	F		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR017925	F		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR017925	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
involved_in	GO:0031427	response to methotrexate	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0487	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
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