CHICK:DUS4

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	DUSP4 (synonyms: MKP2)
Protein Name(s)	Dual specificity protein phosphatase 4 Mitogen-activated protein kinase phosphatase 2 MAP kinase phosphatase 2 MKP-2
External Links
UniProt	Q9PW71
EMBL	AF167296
RefSeq	NP_990169.1
UniGene	Gga.385
ProteinModelPortal	Q9PW71
SMR	Q9PW71
STRING	9031.ENSGALP00000018606
PaxDb	Q9PW71
GeneID	395642
KEGG	gga:395642
CTD	1846
eggNOG	COG2453
HOGENOM	HOG000294080
HOVERGEN	HBG007347
InParanoid	Q9PW71
KO	K04459
PhylomeDB	Q9PW71
Reactome	REACT_25273 REACT_25370
NextBio	20815715
PRO	PR:Q9PW71
Proteomes	UP000000539
GO	GO:0005634 GO:0017017 GO:0004725
Gene3D	3.40.250.10 3.90.190.10
InterPro	IPR000340 IPR020422 IPR024950 IPR008343 IPR029021 IPR001763 IPR000387 IPR016130
PANTHER	PTHR10159
Pfam	PF00782 PF00581
PIRSF	PIRSF000939
PRINTS	PR01764
SMART	SM00195 SM00450
SUPFAM	SSF52799 SSF52821
PROSITE	PS50206 PS00383 PS50056 PS50054

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0016791	phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	F		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	C		Seeded From UniProt	complete
enables	GO:1990439	MAP kinase serine/threonine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	F		Seeded From UniProt	complete
enables	GO:0008330	protein tyrosine/threonine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	F		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	P		Seeded From UniProt	complete
involved_in	GO:0035970	peptidyl-threonine dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	P		Seeded From UniProt	complete
involved_in	GO:0000188	inactivation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13115	P		Seeded From UniProt	complete
enables	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806857 RGD:620625 RGD:620854	F		Seeded From UniProt	complete
enables	GO:0008138	protein tyrosine/serine/threonine phosphatase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001605855 RGD:70978 SGD:S000004998 TAIR:locus:2088080 UniProtKB:P28562 UniProtKB:Q16690 dictyBase:DDB_G0269918	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036844 MGI:MGI:1917936 MGI:MGI:2387107 PANTHER:PTN001605855 PomBase:SPBC1685.01 RGD:70978 SGD:S000001375 SGD:S000004998 TAIR:locus:2082395 UniProtKB:P28562 UniProtKB:Q16828 UniProtKB:Q586S8 UniProtKB:Q9Y6W6	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806857 RGD:620897 UniProtKB:P28562 UniProtKB:Q05923 UniProtKB:Q13115	C		Seeded From UniProt	complete
involved_in	GO:0000188	inactivation of MAPK activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002468407 UniProtKB:Q13115	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008343 InterPro:IPR020422	P		Seeded From UniProt	complete
enables	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340 InterPro:IPR020422	F		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000340 InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008343	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.16	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
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References

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