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CHICK:CTHL2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) CATHL2 (synonyms: CMAP27)
Protein Name(s) Cathelicidin-2

CATH-2 Fowlicidin-2 Myeloid antimicrobial peptide 27

External Links
UniProt Q2IAL7
EMBL AY817057
DQ092352
DQ092350
RefSeq NP_001020001.2
UniGene Gga.9531
ProteinModelPortal Q2IAL7
SMR Q2IAL7
STRING 9031.ENSGALP00000030658
PaxDb Q2IAL7
Ensembl ENSGALT00000031294
GeneID 420407
KEGG gga:420407
CTD 820
eggNOG NOG40811
GeneTree ENSGT00770000120928
HOGENOM HOG000207354
HOVERGEN HBG099601
InParanoid Q2IAL7
KO K13916
OMA TIMETEC
PhylomeDB Q2IAL7
NextBio 20823319
PRO PR:Q2IAL7
Proteomes UP000000539
ExpressionAtlas Q2IAL7
GO GO:0005576
GO:0042742
GO:0050829
GO:0050830
GO:0045087
InterPro IPR001894
PANTHER PTHR10206
Pfam PF00666
ProDom PD001838

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010629

negative regulation of gene expression

PMID:16326712[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0071222)

Seeded From UniProt

complete

involved_in

GO:0008219

cell death

PMID:16326712[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000066)

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:16326712[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:16326712[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001530

lipopolysaccharide binding

PMID:16326712[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019835

cytolysis

PMID:16326712[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000232)

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
UniProtKB:P49913

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
RGD:1559878
UniProtKB:P22226
UniProtKB:P49913
UniProtKB:Q2IAL6
UniProtKB:Q2IAL7
UniProtKB:Q6QLQ5
UniProtKB:R4GJF1

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
RGD:1559878
UniProtKB:P22226
UniProtKB:Q2IAL6
UniProtKB:Q2IAL7
UniProtKB:Q6QLQ5
UniProtKB:R4GJF1

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620

P

Seeded From UniProt

complete

part_of

GO:0042581

specific granule

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108443
PANTHER:PTN000024620
UniProtKB:P49913

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105983
PANTHER:PTN000024620
RGD:1559878
UniProtKB:P49913

C

Seeded From UniProt

complete

enables

GO:0001530

lipopolysaccharide binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000024620
UniProtKB:Q2IAL7
UniProtKB:Q6QLQ5

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001894

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001894

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:25641948[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:25641948[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Xiao, Y et al. (2006) Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity. J. Biol. Chem. 281 2858-67 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Feng, X et al. () High-yield recombinant expression of the chicken antimicrobial peptide fowlicidin-2 in Escherichia coli. Biotechnol. Prog. 31 369-74 PubMed GONUTS page