CHICK:CADH2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CDH2
Protein Name(s)	Cadherin-2 Neural cadherin N-cadherin
External Links
UniProt	P10288
EMBL	X07277 U15563
PIR	A29964
RefSeq	NP_001001615.1
UniGene	Gga.1917
ProteinModelPortal	P10288
SMR	P10288
DIP	DIP-29636N
IntAct	P10288
STRING	9031.ENSGALP00000024371
PaxDb	P10288
Ensembl	ENSGALT00000024417
GeneID	414745
KEGG	gga:414745
CTD	1000
eggNOG	NOG251747
GeneTree	ENSGT00760000118906
HOGENOM	HOG000231254
HOVERGEN	HBG106438
InParanoid	P10288
KO	K06736
OMA	HSGHLQR
OrthoDB	EOG7RJPQM
PhylomeDB	P10288
TreeFam	TF316817
Reactome	REACT_277148 REACT_337530
NextBio	20818714
PRO	PR:P10288
Proteomes	UP000000539
GO	GO:0005912 GO:0016324 GO:0016323 GO:0016342 GO:0070062 GO:0005916 GO:0005925 GO:0016021 GO:0030027 GO:0045202 GO:0005509 GO:0050840 GO:0045295 GO:0048514 GO:0016339 GO:0001502 GO:0007155 GO:0016477 GO:0044331 GO:0010001 GO:0007157 GO:0007156 GO:0060173 GO:0090090 GO:0097118 GO:0097150 GO:0043410 GO:2000809 GO:1902897 GO:0051146
Gene3D	2.60.40.60 4.10.900.10
InterPro	IPR002126 IPR015919 IPR020894 IPR000233 IPR014868 IPR027397 IPR030051
PANTHER	PTHR24027:SF79
Pfam	PF00028 PF01049 PF08758
PRINTS	PR00205
SMART	SM00112 SM01055
SUPFAM	SSF49313
PROSITE	PS00232 PS50268

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	F		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24882712^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032) part_of:(UBERON:0000076)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:24882712^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032) part_of:(UBERON:0000076)	Seeded From UniProt	complete
involved_in	GO:0036032	neural crest cell delamination	PMID:9655818^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001049) occurs_in:(CL:0000333)	Seeded From UniProt	complete
involved_in	GO:0001841	neural tube formation	PMID:9655818^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001049) occurs_in:(CL:0000333)	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:11970959^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0030027)	Seeded From UniProt	complete
involved_in	GO:0098743	cell aggregation	PMID:9548728^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:9548728^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:9548728^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000056) adjacent_to:(GO:0044291)	Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	PMID:9548728^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:19934013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001049)\|part_of:(UBERON:0002328)\|part_of:(UBERON:0000965)	Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:19934013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:19934013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032)	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:19934013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19934013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19934013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000032)	Seeded From UniProt	complete
involved_in	GO:0061561	trigeminal ganglion formation	PMID:19934013^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005085) occurs_in:(UBERON:0003070)	Seeded From UniProt	complete
involved_in	GO:0061563	trigeminal ganglion structural organization	PMID:19934013^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005085) occurs_in:(UBERON:0003070)	Seeded From UniProt	complete
involved_in	GO:0098743	cell aggregation	PMID:19934013^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_formation_of:(UBERON:0003070)	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:19829711^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0003059)\|part_of:(UBERON:0002329)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19829711^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0003059)\|part_of:(UBERON:0002329)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:17604018^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	PMID:3553211^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002329)	Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:3553211^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0003059)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:3553211^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002329)	Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	P		Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	P		Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15116	P		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:15254905^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	PMID:1639850^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14923	F		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:8909549^[11]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0001891)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:8909549^[11]	ECO:0005644	immunoprecipitation evidence used in manual assertion		C	part_of:(UBERON:0001891)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:8909549^[11]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0001891)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:8909549^[11]	ECO:0005644	immunoprecipitation evidence used in manual assertion		C	part_of:(UBERON:0001891)	Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:88354 MGI:MGI:88356 PANTHER:PTN000616280 RGD:69280 UniProtKB:O93319 UniProtKB:P12830 UniProtKB:Q86UP0	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	P		Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P10288 UniProtKB:P55290	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 UniProtKB:P10288	C		Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN000616280 UniProtKB:P10288	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 UniProtKB:P10288	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99551 PANTHER:PTN000616280	F		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P12830 ZFIN:ZDB-GENE-990415-171	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473 UniProtKB:P19022	C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280 UniProtKB:P12830 UniProtKB:P19022 ZFIN:ZDB-GENE-990415-171	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 PANTHER:PTN000616280 RGD:2321 RGD:69280 UniProtKB:P55290	P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473 RGD:69280	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88355 PANTHER:PTN001167473	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 PANTHER:PTN000616280 UniProtKB:P10288 UniProtKB:P33150 UniProtKB:P33151	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280	F		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 RGD:69280	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095414 MGI:MGI:88355 MGI:MGI:99218 PANTHER:PTN000616280 UniProtKB:P55290	P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 UniProtKB:P33151	P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:88354 MGI:MGI:88356 PANTHER:PTN000616280 RGD:69280 UniProtKB:P10288 UniProtKB:P12830 UniProtKB:P19022 UniProtKB:P33151	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105057 MGI:MGI:107435 MGI:MGI:1095414 MGI:MGI:88354 MGI:MGI:88355 MGI:MGI:88356 MGI:MGI:99217 MGI:MGI:99551 PANTHER:PTN000616280 RGD:619745 RGD:621089 RGD:69279 RGD:69280 UniProtKB:O93319 UniProtKB:P10288 UniProtKB:P12830 UniProtKB:P19022 UniProtKB:P22223 UniProtKB:P33151 UniProtKB:P55283 UniProtKB:P55290 UniProtKB:Q6ZTQ4 UniProtKB:Q90763 ZFIN:ZDB-GENE-010606-1	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001167473 UniProtKB:P19022	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88354 PANTHER:PTN000616280 UniProtKB:Q86UP0	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000616280 ZFIN:ZDB-GENE-990415-171	P		Seeded From UniProt	complete
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:1902897	regulation of postsynaptic density protein 95 clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0070445	regulation of oligodendrocyte progenitor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0060563	neuroepithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0048872	homeostasis of number of cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	P		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15116 ensembl:ENSMUSP00000025166	F		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	F		Seeded From UniProt	complete
enables	GO:0045294	alpha-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	F		Seeded From UniProt	complete
part_of	GO:0030864	cortical actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19022 ensembl:ENSP00000269141	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000233 InterPro:IPR002126 InterPro:IPR015919 InterPro:IPR030051	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894 InterPro:IPR030051	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000233 InterPro:IPR002126	P		Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030051	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039808	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	PMID:19492414^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	PMID:15254905^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:15254905^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	PMID:19492414^[13] PMID:16194878^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wu, CY et al. (2014) Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation. Dev. Biol. 392 295-307 PubMed GONUTS page
↑ ^2.0 ^2.1 Nakagawa, S & Takeichi, M (1998) Neural crest emigration from the neural tube depends on regulated cadherin expression. Development 125 2963-71 PubMed GONUTS page
↑ Lambert, M et al. (2002) Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J. Cell Biol. 157 469-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Huttenlocher, A et al. (1998) Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. J. Cell Biol. 141 515-26 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Shiau, CE & Bronner-Fraser, M (2009) N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons. Development 136 4155-64 PubMed GONUTS page
↑ ^6.0 ^6.1 Martins, GG et al. (2009) Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis. PLoS ONE 4 e7429 PubMed GONUTS page
↑ Jin, EJ et al. (2007) MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev. Biol. 308 474-84 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Duband, JL et al. (1987) Adhesion molecules during somitogenesis in the avian embryo. J. Cell Biol. 104 1361-74 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 de Melker, AA et al. (2004) Cellular localization and signaling activity of beta-catenin in migrating neural crest cells. Dev. Dyn. 230 708-26 PubMed GONUTS page
↑ Knudsen, KA & Wheelock, MJ (1992) Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J. Cell Biol. 118 671-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Uchida, N et al. (1996) The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. J. Cell Biol. 135 767-79 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 ^12.25 ^12.26 ^12.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Kim, D et al. (2009) Alterations in the temporal expression and function of cadherin-7 inhibit cell migration and condensation during chondrogenesis of chick limb mesenchymal cells in vitro. J. Cell. Physiol. 221 161-70 PubMed GONUTS page
↑ Zhang, WV & Stott, NS () BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin. Cell Commun. Adhes. 11 89-102 PubMed GONUTS page

[PMID:24882712-1] 1.0 ^1.1 Wu, CY et al. (2014) Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation. Dev. Biol. 392 295-307 PubMed GONUTS page

[PMID:9655818-2] 2.0 ^2.1 Nakagawa, S & Takeichi, M (1998) Neural crest emigration from the neural tube depends on regulated cadherin expression. Development 125 2963-71 PubMed GONUTS page

[PMID:11970959-3] Lambert, M et al. (2002) Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J. Cell Biol. 157 469-79 PubMed GONUTS page

[PMID:9548728-4] 4.0 ^4.1 ^4.2 ^4.3 Huttenlocher, A et al. (1998) Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. J. Cell Biol. 141 515-26 PubMed GONUTS page

[PMID:19934013-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Shiau, CE & Bronner-Fraser, M (2009) N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons. Development 136 4155-64 PubMed GONUTS page

[PMID:19829711-6] 6.0 ^6.1 Martins, GG et al. (2009) Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis. PLoS ONE 4 e7429 PubMed GONUTS page

[PMID:17604018-7] Jin, EJ et al. (2007) MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev. Biol. 308 474-84 PubMed GONUTS page

[PMID:3553211-8] 8.0 ^8.1 ^8.2 Duband, JL et al. (1987) Adhesion molecules during somitogenesis in the avian embryo. J. Cell Biol. 104 1361-74 PubMed GONUTS page

[PMID:15254905-9] 9.0 ^9.1 ^9.2 de Melker, AA et al. (2004) Cellular localization and signaling activity of beta-catenin in migrating neural crest cells. Dev. Dyn. 230 708-26 PubMed GONUTS page

[PMID:1639850-10] Knudsen, KA & Wheelock, MJ (1992) Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J. Cell Biol. 118 671-9 PubMed GONUTS page

[PMID:8909549-11] 11.0 ^11.1 ^11.2 ^11.3 Uchida, N et al. (1996) The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. J. Cell Biol. 135 767-79 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 ^12.25 ^12.26 ^12.27 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19492414-13] 13.0 ^13.1 Kim, D et al. (2009) Alterations in the temporal expression and function of cadherin-7 inhibit cell migration and condensation during chondrogenesis of chick limb mesenchymal cells in vitro. J. Cell. Physiol. 221 161-70 PubMed GONUTS page

[PMID:16194878-14] Zhang, WV & Stott, NS () BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin. Cell Commun. Adhes. 11 89-102 PubMed GONUTS page

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