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CHICK:APTX

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) APTX
Protein Name(s) Aprataxin

Forkhead-associated domain histidine triad-like protein FHA-HIT

External Links
UniProt P61798
EMBL AY208845
UniGene Gga.9488
ProteinModelPortal P61798
STRING 9031.ENSGALP00000033976
PaxDb P61798
PRIDE P61798
eggNOG NOG278510
HOGENOM HOG000248858
HOVERGEN HBG050555
InParanoid P61798
PhylomeDB P61798
Proteomes UP000000539
GO GO:0005730
GO:0005654
GO:0033699
GO:0003677
GO:0046872
GO:0006281
GO:0090305
Gene3D 2.60.200.20
3.30.428.10
InterPro IPR026963
IPR000253
IPR019808
IPR001310
IPR011146
IPR008984
IPR007087
IPR015880
PANTHER PTHR12486
PTHR12486:SF4
SMART SM00355
SUPFAM SSF49879
SSF54197
PROSITE PS00892
PS51084
PS00028

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0033699

DNA 5'-adenosine monophosphate hydrolase activity

PMID:16964241[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:1990165

single-strand break-containing DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000281062
PomBase:SPCC18.09c

F

Seeded From UniProt

complete

enables

GO:0033699

DNA 5'-adenosine monophosphate hydrolase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913658
PANTHER:PTN000281062
PomBase:SPCC18.09c
SGD:S000005784
UniProtKB:P61798
UniProtKB:Q7Z2E3

F

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000281062
PomBase:SPCC18.09c

F

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000281062
UniProtKB:Q7Z2E3

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000281062
UniProtKB:Q7Z2E3

C

Seeded From UniProt

complete

enables

GO:0003725

double-stranded RNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000281062
UniProtKB:Q7Z2E3

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000281062
PomBase:SPCC18.09c

F

Seeded From UniProt

complete

involved_in

GO:0000012

single strand break repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913658
PANTHER:PTN000281062
UniProtKB:Q7Z2E3

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0033699

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0033699

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0033699

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026963

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011146

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026963

P

Seeded From UniProt

complete

enables

GO:0033699

DNA 5'-adenosine monophosphate hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026963

F

Seeded From UniProt

complete

enables

GO:0120108

DNA-3'-diphospho-5'-guanosine diphosphatase

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.12.2

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Ahel, I et al. (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443 713-6 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page