CHICK:ACHA7

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CHRNA7
Protein Name(s)	Neuronal acetylcholine receptor subunit alpha-7
External Links
UniProt	P22770
EMBL	X68586 X52295 X68246
PIR	JN0113
UniGene	Gga.4000
PDB	1KC4 1KL8 1OL3 1OL4 1OL8 1OL9
PDBsum	1KC4 1KL8 1OL3 1OL4 1OL8 1OL9
ProteinModelPortal	P22770
SMR	P22770
IntAct	P22770
STRING	9031.ENSGALP00000006509
eggNOG	NOG235631
HOGENOM	HOG000006756
HOVERGEN	HBG003756
InParanoid	P22770
PhylomeDB	P22770
EvolutionaryTrace	P22770
NextBio	20813529
PRO	PR:P22770
Proteomes	UP000000539
GO	GO:0005892 GO:0030424 GO:0030054 GO:0005737 GO:0030425 GO:0043204 GO:0005886 GO:0045211 GO:0042166 GO:0015464 GO:0004889 GO:0001540 GO:0017081 GO:0042803 GO:0015643 GO:0000187 GO:0006816 GO:0098655 GO:0006874 GO:0050890 GO:0032720 GO:0045766 GO:0008284 GO:0001666 GO:0035094 GO:0007165 GO:0007268
Gene3D	1.20.120.370 2.70.170.10
InterPro	IPR027361 IPR006202 IPR006201 IPR006029 IPR018000 IPR002394
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00254 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0030424	axon	PMID:1578001^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001891) part_of:(UBERON:0006569) part_of:(UBERON:0002606)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:1578001^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001891) part_of:(UBERON:0006569) part_of:(UBERON:0002606)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:1578001^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001891) part_of:(UBERON:0006569) part_of:(UBERON:0002606)	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:1578001^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001891) part_of:(UBERON:0006569) part_of:(UBERON:0002606)	Seeded From UniProt	complete
involved_in	GO:0050890	cognition	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
enables	GO:0017081	chloride channel regulator activity	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
enables	GO:0015643	toxic substance binding	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:8145738^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36544	P		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 RGD:2348 UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P		Seeded From UniProt	complete
contributes_to	GO:0015464	acetylcholine receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99779 PANTHER:PTN001450553 RGD:2348	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 RGD:2348 UniProtKB:P36544	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C		Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Britto, LR et al. (1992) Immunohistochemical localization of nicotinic acetylcholine receptor subunits in the mesencephalon and diencephalon of the chick (Gallus gallus). J. Comp. Neurol. 317 325-40 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 Peng, X et al. (1994) Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45 546-54 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1578001-1] 1.0 ^1.1 ^1.2 ^1.3 Britto, LR et al. (1992) Immunohistochemical localization of nicotinic acetylcholine receptor subunits in the mesencephalon and diencephalon of the chick (Gallus gallus). J. Comp. Neurol. 317 325-40 PubMed GONUTS page

[PMID:8145738-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 Peng, X et al. (1994) Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45 546-54 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:ACHA7

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