CHICK:ACHA4

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CHRNA4
Protein Name(s)	Neuronal acetylcholine receptor subunit alpha-4
External Links
UniProt	P09482
EMBL	X07348 X07349 X07350 X07351 X07352 X07399 AJ250361
PIR	S00379
RefSeq	NP_990145.1
UniGene	Gga.4440
ProteinModelPortal	P09482
SMR	P09482
IntAct	P09482
STRING	9031.ENSGALP00000009302
BindingDB	P09482
ChEMBL	CHEMBL5569
PaxDb	P09482
Ensembl	ENSGALT00000009316
GeneID	395606
KEGG	gga:395606
CTD	1137
eggNOG	NOG290206
GeneTree	ENSGT00760000118930
HOGENOM	HOG000006756
HOVERGEN	HBG003756
InParanoid	P09482
KO	K04806
OMA	CASIFPA
OrthoDB	EOG72JWGV
PhylomeDB	P09482
TreeFam	TF315605
Reactome	REACT_297054 REACT_322266 REACT_341444
NextBio	20815679
PRO	PR:P09482
Proteomes	UP000000539
GO	GO:0005892 GO:0030054 GO:0009897 GO:0045211 GO:0015464 GO:0004889 GO:0001508 GO:0042113 GO:0035095 GO:0006816 GO:0050890 GO:0006281 GO:0035640 GO:0007626 GO:0051899 GO:0014059 GO:0060080 GO:0007585 GO:0001666 GO:0006979 GO:0019233 GO:0007271
Gene3D	1.20.120.370 2.70.170.10
InterPro	IPR027361 IPR006202 IPR006201 IPR006029 IPR018000 IPR002394
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00254 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0050877	nervous system process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P	Seeded From UniProt	complete
contributes_to	GO:0042166	acetylcholine binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 PANTHER:PTN002498457 RGD:2346 RGD:2347 RGD:621544 ZFIN:ZDB-GENE-980526-137	F	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 MGI:MGI:87889 PANTHER:PTN002498457 UniProtKB:P43681 ZFIN:ZDB-GENE-090505-3	P	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P	Seeded From UniProt	complete
contributes_to	GO:0015464	acetylcholine receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87888 PANTHER:PTN002498457 UniProtKB:P30532 UniProtKB:P43681 ZFIN:ZDB-GENE-980526-137	F	Seeded From UniProt	complete
involved_in	GO:0007274	neuromuscular synaptic transmission	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002498457 UniProtKB:P02708 ZFIN:ZDB-GENE-980526-137	P	Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN002498457 RGD:2346	P	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P	Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87888 MGI:MGI:87889 PANTHER:PTN002498457 RGD:2346 RGD:2347 RGD:621544 RGD:69277 UniProtKB:P43681 ZFIN:ZDB-GENE-090505-3 ZFIN:ZDB-GENE-980526-137	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C	Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	C	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	C	Seeded From UniProt	complete
involved_in	GO:0095500	acetylcholine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0035640	exploration behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0035095	behavioral response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	F	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	C	Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	F	Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	C	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0007585	respiratory gaseous exchange	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	C	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	F	Seeded From UniProt	complete
involved_in	GO:0001508	action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70174 ensembl:ENSMUSP00000066338	P	Seeded From UniProt	complete
involved_in	GO:0050890	cognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
involved_in	GO:0035095	behavioral response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	F	Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	C	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43681 ensembl:ENSP00000359285	P	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006201	F	Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	C	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	F	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	P	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:ACHA4

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