CHICK:ACE

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ACE (synonyms: DCP1)
Protein Name(s)	Angiotensin-converting enzyme ACE Dipeptidyl carboxypeptidase I Kininase II
External Links
UniProt	Q10751
EMBL	L40175
PIR	JC2489
UniGene	Gga.3781
ProteinModelPortal	Q10751
SMR	Q10751
STRING	9031.ENSGALP00000039731
MEROPS	M02.001
PaxDb	Q10751
eggNOG	NOG71044
HOGENOM	HOG000007838
HOVERGEN	HBG000264
InParanoid	Q10751
PhylomeDB	Q10751
Proteomes	UP000000539
GO	GO:0016021 GO:0004180 GO:0046872 GO:0008237 GO:0008241
InterPro	IPR001548
PANTHER	PTHR10514
Pfam	PF01401
PRINTS	PR00791
PROSITE	PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060319	primitive erythrocyte differentiation	PMID:15367438^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:15367438^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008239	dipeptidyl-peptidase activity	PMID:15367438^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:1323442^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:7811282^[3]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P12821	F	Seeded From UniProt	complete
enables	GO:0008241	peptidyl-dipeptidase activity	PMID:7811282^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:7811282^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045777	positive regulation of blood pressure	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053931 RGD:2493	P	Seeded From UniProt	complete
enables	GO:0008241	peptidyl-dipeptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0012037 FB:FBgn0016122 MGI:MGI:87874 PANTHER:PTN000053976 RGD:2493 UniProtKB:P12821	F	Seeded From UniProt	complete
enables	GO:0008239	dipeptidyl-peptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053976 UniProtKB:F1NYM0 UniProtKB:Q10751	F	Seeded From UniProt	complete
enables	GO:0008238	exopeptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001630211 UniProtKB:P12821	F	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87874 PANTHER:PTN000053976 RGD:2493 UniProtKB:P12821	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1917258 MGI:MGI:87874 PANTHER:PTN001630211 RGD:2493 UniProtKB:P12821 UniProtKB:Q9BYF1	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0012037 FB:FBgn0016122 PANTHER:PTN001630211 RGD:2493 RGD:728890 UniProtKB:F1NYM0 UniProtKB:P12821 UniProtKB:Q9BYF1	C	Seeded From UniProt	complete
involved_in	GO:0003084	positive regulation of systemic arterial blood pressure	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87874 PANTHER:PTN000053931 RGD:2493	P	Seeded From UniProt	complete
involved_in	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000053931 UniProtKB:P12821	P	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001548	P	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001548	F	Seeded From UniProt	complete
enables	GO:0008241	peptidyl-dipeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001548	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001548	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0004180	carboxypeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0121	F	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Savary, K et al. (2005) Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo. Blood 105 103-10 PubMed GONUTS page
↑ Polanco, MJ et al. (1992) Inhibition and affinity chromatography of chicken lung angiotensin I-converting enzyme with captopril. Comp. Biochem. Physiol., B 102 527-33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Esther, CR Jr et al. (1994) Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals. Biochem. Biophys. Res. Commun. 205 1916-21 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15367438-1] 1.0 ^1.1 ^1.2 Savary, K et al. (2005) Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo. Blood 105 103-10 PubMed GONUTS page

[PMID:1323442-2] Polanco, MJ et al. (1992) Inhibition and affinity chromatography of chicken lung angiotensin I-converting enzyme with captopril. Comp. Biochem. Physiol., B 102 527-33 PubMed GONUTS page

[PMID:7811282-3] 3.0 ^3.1 ^3.2 Esther, CR Jr et al. (1994) Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals. Biochem. Biophys. Res. Commun. 205 1916-21 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:ACE

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