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PMID:7811282

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Citation

Esther, CR Jr, Thomas, KE and Bernstein, KE (1994) Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals. Biochem. Biophys. Res. Commun. 205:1916-21

Abstract

Chicken angiotensin converting enzyme (ACE) cDNA was cloned based on homology to the mouse ACE sequence. The chicken ACE protein is highly homologous to the somatic isozyme of ACE found in human, mouse, bovine, and rabbit. Like the mammalian somatic forms, the chicken enzyme consists of two putative zinc binding sites at the center of two homologous domains. All known functional residues are absolutely conserved. Unlike the mammals, no evidence for a single domain, testis specific form of ACE was found in the chicken testis by either Northern blot or enzyme assay. This result is unexpected since the adult mammalian testis expresses one of the highest tissue levels of ACE.

Links

PubMed Online version:10.1006/bbrc.1994.2894

Keywords

Amino Acid Sequence; Animals; Cattle; Chickens; Cloning, Molecular; Conserved Sequence; DNA, Complementary/genetics; Humans; Isoenzymes/genetics; Male; Mice; Molecular Sequence Data; Organ Specificity; Peptidyl-Dipeptidase A/genetics; Rabbits; Species Specificity; Testis/enzymology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:F1NYM0

involved_in

GO:0042447: hormone catabolic process

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:F1NYM0

involved_in

GO:0003081: regulation of systemic arterial blood pressure by renin-angiotensin

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:F1NYM0

located_in

GO:0009897: external side of plasma membrane

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

C

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0031711: bradykinin receptor binding

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0031404: chloride ion binding

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0031434: mitogen-activated protein kinase kinase binding

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0008237: metallopeptidase activity

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0008238: exopeptidase activity

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0008240: tripeptidyl-peptidase activity

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0008241: peptidyl-dipeptidase activity

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0008270: zinc ion binding

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0004175: endopeptidase activity

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0003779: actin binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P12821-1

F

Seeded From UniProt

complete

CHICK:F1NYM0

located_in

GO:0005886: plasma membrane

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

C

Seeded From UniProt

complete

CHICK:F1NYM0

involved_in

GO:0001822: kidney development

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0070573: metallodipeptidase activity

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

involved_in

GO:0060177: regulation of angiotensin metabolic process

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:F1NYM0

located_in

GO:0005764: lysosome

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

C

Seeded From UniProt

complete

CHICK:F1NYM0

located_in

GO:0070062: extracellular exosome

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

C

Seeded From UniProt

complete

CHICK:F1NYM0

located_in

GO:0005615: extracellular space

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

C

Seeded From UniProt

complete

CHICK:F1NYM0

located_in

GO:0005768: endosome

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

C

Seeded From UniProt

complete

CHICK:F1NYM0

enables

GO:0051019: mitogen-activated protein kinase binding

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:F1NYM0

involved_in

GO:0043171: peptide catabolic process

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:F1NYM0

involved_in

GO:0050482: arachidonic acid secretion

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:F1NYM0

involved_in

GO:0050435: amyloid-beta metabolic process

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

P

Seeded From UniProt

complete

CHICK:ACE

enables

GO:0008270: zinc ion binding

ECO:0000247: sequence alignment evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

CHICK:ACE

enables

GO:0008241: peptidyl-dipeptidase activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

CHICK:ACE

enables

GO:0008237: metallopeptidase activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete


See also

References

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