CBDP:BXD

Species (Taxon ID)	Clostridium botulinum D phage (Clostridium botulinum D bacteriophage). (29342)
Gene Name(s)	botD
Protein Name(s)	Botulinum neurotoxin type D BoNT/D Bontoxilysin-D Botulinum neurotoxin D light chain LC Botulinum neurotoxin D heavy chain HC
External Links
UniProt	P19321
EMBL	X54254 S49407
PIR	S11455
PDB	2FPQ 3N7J 3OBR 3OBT 3OGG 3RMX 3RMY 5BQM 5BQN
PDBsum	2FPQ 3N7J 3OBR 3OBT 3OGG 3RMX 3RMY 5BQM 5BQN
SMR	P19321
DrugBank	DB13902
UniLectin	P19321
PRIDE	P19321
BRENDA	3.4.24.69
Reactome	R-HSA-5250955
EvolutionaryTrace	P19321
GO	GO:0005576 GO:1905576 GO:0004222 GO:0008320 GO:0090729 GO:0008270 GO:0046929
Gene3D	1.20.1120.10
InterPro	IPR000395 IPR036248 IPR013320 IPR011065 IPR013104 IPR012928 IPR012500
Pfam	PF01742 PF07951 PF07953 PF07952
PRINTS	PR00760
SUPFAM	SSF49899 SSF50386 SSF58091
PROSITE	PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes
enables	GO:0008270	zinc ion binding	PMID:16519520^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:1905576	ganglioside GT1b binding	PMID:20704566^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008320	P	Seeded From UniProt
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008320	P	Seeded From UniProt
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012928	C	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	P	Seeded From UniProt
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F	Seeded From UniProt
enables	GO:0008320	protein transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500	F	Seeded From UniProt
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500 InterPro:IPR012928	P	Seeded From UniProt
involved_in	GO:0046929	negative regulation of neurotransmitter secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395 InterPro:IPR012500 InterPro:IPR012928 InterPro:IPR013104	P	Seeded From UniProt
enables	GO:0008320	protein transmembrane transporter activity	Reactome:R-HSA-5250616	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P	Seeded From UniProt
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F	Seeded From UniProt
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F	Seeded From UniProt
enables	GO:0008270	zinc ion binding	PMID:16519520^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:1905576	ganglioside GT1b binding	PMID:20704566^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:0008320	protein transmembrane transporter activity	Reactome:R-HSA-5250616	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008320	P	Seeded From UniProt
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008320	P	Seeded From UniProt
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012928	C	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	P	Seeded From UniProt
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F	Seeded From UniProt
enables	GO:0008320	protein transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500	F	Seeded From UniProt
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500 InterPro:IPR012928	P	Seeded From UniProt
involved_in	GO:0046929	negative regulation of neurotransmitter secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395 InterPro:IPR012500 InterPro:IPR012928 InterPro:IPR013104	P	Seeded From UniProt
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P	Seeded From UniProt
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F	Seeded From UniProt
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F	Seeded From UniProt
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Arndt, JW et al. (2006) Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity. Biochemistry 45 3255-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Strotmeier, J et al. (2010) Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem. J. 431 207-16 PubMed GONUTS page

[PMID:16519520-1] 1.0 ^1.1 Arndt, JW et al. (2006) Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity. Biochemistry 45 3255-62 PubMed GONUTS page

[PMID:20704566-2] 2.0 ^2.1 Strotmeier, J et al. (2010) Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem. J. 431 207-16 PubMed GONUTS page

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CBDP:BXD

Contents

Annotations

Notes

References

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