CANLF:F6UNA4

Species (Taxon ID)	Canis lupus familiaris (Dog) (Canis familiaris). (9615)
Gene Name(s)	XRCC4 (ECO:0000313 with Ensembl:ENSCAFP00000012665)
Protein Name(s)	Uncharacterized protein (ECO:0000313 with Ensembl:ENSCAFP00000012665)
External Links
UniProt	F6UNA4
EMBL	AAEX03002093
RefSeq	XP_005618210.1
STRING	9615.ENSCAFP00000030922
PaxDb	F6UNA4
Ensembl	ENSCAFT00000013692
GeneID	488923
CTD	7518
eggNOG	ENOG410IJSN ENOG410Y7Z3
GeneTree	ENSGT00390000017079
OMA	WNDVQER
Reactome	[www.reactome.org/content/detail/R-CFA-3108214 R-CFA-3108214] [www.reactome.org/content/detail/R-CFA-5693571 R-CFA-5693571]
Proteomes	UP000002254
GO	GO:0005634 GO:0003677 GO:0006310 GO:0006302
Gene3D	1.20.5.370 2.170.210.10
InterPro	IPR010585 IPR014751 IPR009089
Pfam	PF06632
SUPFAM	SSF50809

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009089 InterPro:IPR010585	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009089 InterPro:IPR010585	C		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009089 InterPro:IPR010585	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009089 InterPro:IPR010585	P		Seeded From UniProt	complete
	GO:0035861	site of double-strand break	PMID:27644316	ECO:0000314			C		Figure 4C shows how XRCC4 quickly accumulates at the sites of double-stranded breaks in the DNA since the merged image of XRCC4 localization and antibody detection of γH2AX, a marker of DSBs, indicates that XRCC4 is heavily present at the site of DSBs. The regulation of XRCC4 localizations might play a key role in regulating NHEJ activity since the XRCC4/DNA Ligase IV complex is crucial for the final ligation of DSBs through NHEJ.	complete CACAO 12502
	GO:0090435	protein localization to nuclear envelope	PMID:27644316	ECO:0000315	mutant phenotype evidence used in manual assertion		P		In figure 1B and 1C, anti-XRCC4 antibodies were stained in order to show the localization of XRCC4. When overlaid with the images of stained nuclei, the merged image showed that XRCC4 is located within the nuclei.	complete CACAO 12500
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References

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