CANFA:DUOX1

Species (Taxon ID)	Canis familiaris (Dog) (Canis lupus familiaris). (9615)
Gene Name(s)	DUOX1 (synonyms: THOX1)
Protein Name(s)	Dual oxidase 1 NADPH thyroid oxidase 1 Thyroid oxidase 1
External Links
UniProt	Q9MZF4
EMBL	AF230497
RefSeq	NP_001003122.1 XP_005638229.1 XP_005638230.1
UniGene	Cfa.3587
ProteinModelPortal	Q9MZF4
STRING	9615.ENSCAFP00000020209
PeroxiBase	3336
PRIDE	Q9MZF4
Ensembl	ENSCAFT00000021757
GeneID	403720
KEGG	cfa:403720
CTD	53905
eggNOG	COG5126
GeneTree	ENSGT00550000074350
HOGENOM	HOG000231774
HOVERGEN	HBG080428
InParanoid	Q9MZF4
KO	K13411
OMA	CHFQEVI
OrthoDB	EOG7GN2KV
TreeFam	TF105424
UniPathway	UPA00194
NextBio	20817223
Proteomes	UP000002254
GO	GO:0016324 GO:0016021 GO:0005509 GO:0020037 GO:0016174 GO:0050661 GO:0004601 GO:0042335 GO:0019221 GO:0042446 GO:0050665 GO:0042744 GO:0051591 GO:0042554 GO:0006590
Gene3D	1.10.238.10 1.10.640.10
InterPro	IPR029595 IPR011992 IPR018247 IPR002048 IPR013112 IPR017927 IPR013130 IPR013121 IPR010255 IPR019791 IPR017938
PANTHER	PTHR11972:SF37
Pfam	PF03098 PF13499 PF08022 PF01794 PF08030
PRINTS	PR00457
SMART	SM00054
SUPFAM	SSF48113 SSF63380
PROSITE	PS00018 PS50222 PS51384 PS50292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NRD9	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NRD9	C	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NRD8	P	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:10806195^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:10806195^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042335	cuticle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NRD9	P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NRD9	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:10806195^[1]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	PMID:10806195^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN001735877 PomBase:SPBC1683.09c RGD:620600 SGD:S000003128 SGD:S000004037 SGD:S000005512 TAIR:locus:2017789 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2025366 TAIR:locus:2157032 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 TAIR:locus:2178677 TAIR:locus:2178687 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9NPH5 UniProtKB:Q9NRD8 UniProtKB:Q9SBI0 UniProtKB:Q9Y5S8 WB:WBGene00000253 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	P	Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN000239643 RGD:620574 RGD:620598 RGD:620600 UniProtKB:P04839 UniProtKB:Q9Y5S8	C	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 RGD:620598 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101	P	Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	F	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:88574 PANTHER:PTN000239643 UniProtKB:P04839 ZFIN:ZDB-GENE-091117-14 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653 dictyBase:DDB_G0291117	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2139422 MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN001735877 RGD:620574 RGD:620598 RGD:620600 SGD:S000005512 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2157027 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 UniProtKB:O81209 UniProtKB:P04839 UniProtKB:Q9Y5S8 WB:WBGene00000253	C	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2AQ92 ensembl:ENSMUSP00000097060	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2AQ92 ensembl:ENSMUSP00000097060	C	Seeded From UniProt	complete
involved_in	GO:2000147	positive regulation of cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	P	Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	P	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	P	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	P	Seeded From UniProt	complete
involved_in	GO:0042335	cuticle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	P	Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	C	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NRD9 ensembl:ENSP00000317997	C	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P	Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029595	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	F	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029595	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	P	Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.6.3.1	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0376	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F	Seeded From UniProt	complete
involved_in	GO:0042446	hormone biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0893	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
involved_in	GO:0006590	thyroid hormone generation	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00194	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 De Deken, X et al. (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J. Biol. Chem. 275 23227-33 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10806195-1] 1.0 ^1.1 ^1.2 ^1.3 De Deken, X et al. (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J. Biol. Chem. 275 23227-33 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CANFA:DUOX1

Contents

Annotations

Notes

References

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