CANAL:HWP1

Species (Taxon ID)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). (237561)
Gene Name(s)	HWP1 (synonyms: ECE2)
Protein Name(s)	Hyphal wall protein 1 Cell elongation protein 2
External Links
UniProt	P46593
EMBL	U64206 AF001978 AACQ01000139 AACQ01000138 U29369
RefSeq	XP_709961.1 XP_712998.1
STRING	5476.CAL0003753
GeneID	3645372 3645386
KEGG	cal:CaO19.1321 cal:CaO19.8901
CGD	CAL0003753
eggNOG	NOG12793
InParanoid	P46593
OrthoDB	EOG718KPF
Proteomes	UP000000559
GO	GO:0031225 GO:0009986 GO:0005576 GO:0009277 GO:0030446 GO:0005937 GO:0050839 GO:0044406 GO:0007155 GO:0043708 GO:0043707 GO:0031505 GO:0044117 GO:0009405 GO:0016337 GO:0044011
InterPro	IPR025928
Pfam	PF13928

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0098609	cell-cell adhesion	PMID:20709785^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:20709785^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0044406	adhesion of symbiont to host	PMID:15262971^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044406	adhesion of symbiont to host	PMID:10066176^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0044182	filamentous growth of a population of unicellular organisms	PMID:15817775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044117	growth of symbiont in host	PMID:22544909^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043708	cell adhesion involved in biofilm formation	PMID:20709785^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043707	cell adhesion involved in single-species biofilm formation in or on host organism	PMID:17030992^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031505	fungal-type cell wall organization	PMID:18765290^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030446	hyphal cell wall	PMID:19555771^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030446	hyphal cell wall	PMID:15262971^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030446	hyphal cell wall	PMID:14565982^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8626424^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:18723603^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	PMID:12011025^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	PMID:10066176^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0009405	pathogenesis	PMID:15817775^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009277	fungal-type cell wall	PMID:18723603^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009277	fungal-type cell wall	PMID:18227255^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009277	fungal-type cell wall	PMID:14651643^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:20709785^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005937	mating projection	PMID:14565982^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C	Seeded From UniProt	complete
part_of	GO:0005618	cell wall	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0134 UniProtKB-SubCell:SL-0041	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Nobbs, AH et al. (2010) Heterologous expression of Candida albicans cell wall-associated adhesins in Saccharomyces cerevisiae Reveals differential specificities in adherence and biofilm formation and in binding oral Streptococcus gordonii. Eukaryotic Cell 9 1622-34 PubMed GONUTS page
↑ ^2.0 ^2.1 Staab, JF et al. (2004) Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification. J. Biol. Chem. 279 40737-47 PubMed GONUTS page
↑ ^3.0 ^3.1 Staab, JF et al. (1999) Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283 1535-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Sharkey, LL et al. (2005) Flanking direct repeats of hisG alter URA3 marker expression at the HWP1 locus of Candida albicans. Microbiology (Reading, Engl.) 151 1061-71 PubMed GONUTS page
↑ Fanning, S et al. (2012) Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo. Eukaryotic Cell 11 896-904 PubMed GONUTS page
↑ Nobile, CJ et al. (2006) Function of Candida albicans adhesin Hwp1 in biofilm formation. Eukaryotic Cell 5 1604-10 PubMed GONUTS page
↑ Plaine, A et al. (2008) Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity. Fungal Genet. Biol. 45 1404-14 PubMed GONUTS page
↑ Maddi, A et al. (2009) Trifluoromethanesulfonic acid-based proteomic analysis of cell wall and secreted proteins of the ascomycetous fungi Neurospora crassa and Candida albicans. Fungal Genet. Biol. 46 768-81 PubMed GONUTS page
↑ ^9.0 ^9.1 Daniels, KJ et al. (2003) The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating. Mol. Biol. Cell 14 4920-30 PubMed GONUTS page
↑ Staab, JF et al. (1996) Developmental expression of a tandemly repeated, proline-and glutamine-rich amino acid motif on hyphal surfaces on Candida albicans. J. Biol. Chem. 271 6298-305 PubMed GONUTS page
↑ ^11.0 ^11.1 Mao, Y et al. (2008) C-terminal signals regulate targeting of glycosylphosphatidylinositol-anchored proteins to the cell wall or plasma membrane in Candida albicans. Eukaryotic Cell 7 1906-15 PubMed GONUTS page
↑ Sundstrom, P et al. (2002) Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus. Infect. Immun. 70 3281-3 PubMed GONUTS page
↑ Sosinska, GJ et al. (2008) Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology (Reading, Engl.) 154 510-520 PubMed GONUTS page
↑ Mao, Y et al. (2003) Use of green fluorescent protein fusions to analyse the N- and C-terminal signal peptides of GPI-anchored cell wall proteins in Candida albicans. Mol. Microbiol. 50 1617-28 PubMed GONUTS page

[PMID:20709785-1] 1.0 ^1.1 ^1.2 ^1.3 Nobbs, AH et al. (2010) Heterologous expression of Candida albicans cell wall-associated adhesins in Saccharomyces cerevisiae Reveals differential specificities in adherence and biofilm formation and in binding oral Streptococcus gordonii. Eukaryotic Cell 9 1622-34 PubMed GONUTS page

[PMID:15262971-2] 2.0 ^2.1 Staab, JF et al. (2004) Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification. J. Biol. Chem. 279 40737-47 PubMed GONUTS page

[PMID:10066176-3] 3.0 ^3.1 Staab, JF et al. (1999) Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283 1535-8 PubMed GONUTS page

[PMID:15817775-4] 4.0 ^4.1 Sharkey, LL et al. (2005) Flanking direct repeats of hisG alter URA3 marker expression at the HWP1 locus of Candida albicans. Microbiology (Reading, Engl.) 151 1061-71 PubMed GONUTS page

[PMID:22544909-5] Fanning, S et al. (2012) Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo. Eukaryotic Cell 11 896-904 PubMed GONUTS page

[PMID:17030992-6] Nobile, CJ et al. (2006) Function of Candida albicans adhesin Hwp1 in biofilm formation. Eukaryotic Cell 5 1604-10 PubMed GONUTS page

[PMID:18765290-7] Plaine, A et al. (2008) Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity. Fungal Genet. Biol. 45 1404-14 PubMed GONUTS page

[PMID:19555771-8] Maddi, A et al. (2009) Trifluoromethanesulfonic acid-based proteomic analysis of cell wall and secreted proteins of the ascomycetous fungi Neurospora crassa and Candida albicans. Fungal Genet. Biol. 46 768-81 PubMed GONUTS page

[PMID:14565982-9] 9.0 ^9.1 Daniels, KJ et al. (2003) The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating. Mol. Biol. Cell 14 4920-30 PubMed GONUTS page

[PMID:8626424-10] Staab, JF et al. (1996) Developmental expression of a tandemly repeated, proline-and glutamine-rich amino acid motif on hyphal surfaces on Candida albicans. J. Biol. Chem. 271 6298-305 PubMed GONUTS page

[PMID:18723603-11] 11.0 ^11.1 Mao, Y et al. (2008) C-terminal signals regulate targeting of glycosylphosphatidylinositol-anchored proteins to the cell wall or plasma membrane in Candida albicans. Eukaryotic Cell 7 1906-15 PubMed GONUTS page

[PMID:12011025-12] Sundstrom, P et al. (2002) Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus. Infect. Immun. 70 3281-3 PubMed GONUTS page

[PMID:18227255-13] Sosinska, GJ et al. (2008) Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology (Reading, Engl.) 154 510-520 PubMed GONUTS page

[PMID:14651643-14] Mao, Y et al. (2003) Use of green fluorescent protein fusions to analyse the N- and C-terminal signal peptides of GPI-anchored cell wall proteins in Candida albicans. Mol. Microbiol. 50 1617-28 PubMed GONUTS page

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CANAL:HWP1

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