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CAEEL:O45100

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) mec-17 (ECO:0000255 with HAMAP-Rule:MF_03130)
Protein Name(s) Alpha-tubulin N-acetyltransferase 1 (ECO:0000255 with HAMAP-Rule:MF_03130)

Alpha-TAT 1 (ECO:0000255 with HAMAP-Rule:MF_03130) TAT 1 (ECO:0000255 with HAMAP-Rule:MF_03130) Mechanosensory abnormality protein 17 (ECO:0000255 with HAMAP-Rule:MF_03130)

External Links
UniProt O45100
EMBL FO081188
PIR T32979
RefSeq NP_501337.1
UniGene Cel.12810
ProteinModelPortal O45100
SMR O45100
STRING 6239.F57H12.7
PaxDb O45100
PRIDE O45100
EnsemblMetazoa F57H12.7
GeneID 177596
KEGG cel:CELE_F57H12.7
UCSC F57H12.7
CTD 177596
WormBase F57H12.7
eggNOG NOG249793
HOGENOM HOG000021174
InParanoid O45100
OMA MQVNADL
OrthoDB EOG76739W
PhylomeDB O45100
NextBio 897516
Proteomes UP000001940
GO GO:0004468
GO:0019799
GO:0071929
GO:0042490
GO:0048666
GO:0006473
GO:0070507
GO:0001966
Gene3D 3.40.630.30
HAMAP MF_03130
InterPro IPR016181
IPR007965
PANTHER PTHR12327
Pfam PF05301
PROSITE PS51730

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0019799

tubulin N-acetyltransferase activity

PMID:20829795[1]

IMP: Inferred from Mutant Phenotype

F

Figure 2. Along with W06B11.1, MEC-17 acetylates alpha tubulin. This was determined by an antibody-binding assay. Mutant C. elegans without W06B11.1 and MEC-17 did not display alpha-tubulin acetylation.

complete
CACAO 3598

GO:0001966

thigmotaxis

PMID:20829795[1]

IGI: Inferred from Genetic Interaction

P

Missing: with/from

GO:0006473

protein acetylation

PMID:20829795[1]

IGI: Inferred from Genetic Interaction

P

Missing: with/from

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

complete

GO:0019799

tubulin N-acetyltransferase activity

PMID:20829795[1]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0042490

mechanoreceptor differentiation

PMID:8187641[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001966

thigmotaxis

PMID:20829795[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00021059

P

Seeded From UniProt

complete

GO:0001966

thigmotaxis

PMID:20829795[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00093292

P

Seeded From UniProt

complete

GO:0001966

thigmotaxis

PMID:24846647[3]

IGI: Inferred from Genetic Interaction

WB:WBGene00021059

P

Seeded From UniProt

complete

GO:0001966

thigmotaxis

PMID:24846647[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004468

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

PMID:20829795[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q22XZ3

F

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007965

C

Seeded From UniProt

complete

GO:0006473

protein acetylation

PMID:20829795[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00021059

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03130

F

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

GO:0019799

tubulin N-acetyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007965

F

Seeded From UniProt

complete

GO:0019799

tubulin N-acetyltransferase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.108

F

Seeded From UniProt

complete

GO:0019799

tubulin N-acetyltransferase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03130

F

Seeded From UniProt

complete

GO:0019799

tubulin N-acetyltransferase activity

PMID:20829795[1]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0042490

mechanoreceptor differentiation

PMID:8187641[2]

IMP: Inferred from Mutant Phenotype

WB:WBVar00266627

P

Seeded From UniProt

complete

GO:0048666

neuron development

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03130

P

Seeded From UniProt

complete

GO:0070507

regulation of microtubule cytoskeleton organization

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03130

P

Seeded From UniProt

complete

GO:0071929

alpha-tubulin acetylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007965

P

Seeded From UniProt

complete

GO:0071929

alpha-tubulin acetylation

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03130

P

Seeded From UniProt

complete

colocalizes_with

GO:0005874

microtubule

PMID:20829795[1]

IC: Inferred by Curator

GO:0019799

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Akella, JS et al. (2010) MEC-17 is an alpha-tubulin acetyltransferase. Nature 467 218-22 PubMed GONUTS page
  2. 2.0 2.1 Mitani, S et al. (1993) Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development 119 773-83 PubMed GONUTS page
  3. 3.0 3.1 Davenport, AM et al. (2014) Structural and functional characterization of the α-tubulin acetyltransferase MEC-17. J. Mol. Biol. 426 2605-16 PubMed GONUTS page