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Mitani, S, Du, H, Hall, DH, Driscoll, M and Chalfie, M (1993) Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development 119:773-83
Six touch receptor neurons with distinctive morphological features sense gentle touch in Caenorhabditis elegans. Previous studies have identified three genes (lin-32, unc-86 and mec-3) that regulate touch cell development. However, since other cell types also require these genes, we suspected that other genes help restrict the expression of touch cell characteristics to the six neurons seen in the wild type. To identify such genes, we have examined mutants defective in genes required for the development of other C. elegans cells for changes in the pattern of touch cell-specific features. Mutations in seven genes either reduce (lin-14) or increase (lin-4, egl-44, egl-46, sem-4, ced-3 and ced-4) the number of touch receptor-like cells. The combinatorial action of these genes, all of which are required for the production of many cell types, restrict the number of cells expressing touch receptor characteristics in wild-type animals by acting as positive and negative regulators and by removing cells by programmed cell death.
Animals; Base Sequence; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/ultrastructure; Cell Differentiation/genetics; Gene Expression Regulation/physiology; Genotype; Microscopy, Electron; Microscopy, Fluorescence; Molecular Sequence Data; Mutation/genetics; Neurons, Afferent/physiology; Neurons, Afferent/ultrastructure; Touch
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