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CAEEL:MES4

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) mes-4
Protein Name(s) Histone-lysine N-methyltransferase mes-4

Maternal-effect sterile protein 4

External Links
UniProt Q9NH52
EMBL AF233290
AL021448
PIR T26577
RefSeq NP_506333.1
UniGene Cel.6195
ProteinModelPortal Q9NH52
SMR Q9NH52
BioGrid 44841
IntAct Q9NH52
MINT MINT-1040434
STRING 6239.Y2H9A.1
PaxDb Q9NH52
EnsemblMetazoa Y2H9A.1
GeneID 179824
KEGG cel:CELE_Y2H9A.1
UCSC Y2H9A.1
CTD 43351
WormBase Y2H9A.1
eggNOG COG2940
GeneTree ENSGT00760000118855
InParanoid Q9NH52
KO K07117
OMA CYPAGAR
PhylomeDB Q9NH52
NextBio 907012
Proteomes UP000001940
GO GO:0030849
GO:0005694
GO:0000228
GO:0000805
GO:0042054
GO:0046975
GO:0008270
GO:0016458
GO:0018992
GO:0010452
GO:0016571
GO:0040029
InterPro IPR003616
IPR001214
IPR001841
Pfam PF00856
SMART SM00508
SM00184
SM00317
PROSITE PS50868
PS50280

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016571

histone methylation

PMID:20824077[1]

ECO:0000315

P

"MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline programs." Figure 4: "H3K36me3 levels in mutants are reduced relative to wild type."

complete
CACAO 3671

GO:0016571

histone methylation

PMID:20824077[1]

ECO:0000315

P

"MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline programs." Figure 4: "H3K36me3 levels in mutants are reduced relative to wild type."

complete
CACAO 3673

involved_in

GO:0016571

histone methylation

PMID:20824077[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0040029

regulation of gene expression, epigenetic

PMID:23103171[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(WBbt:0005784)

Seeded From UniProt

complete

involved_in

GO:0010452

histone H3-K36 methylation

PMID:23103171[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046975

histone methyltransferase activity (H3-K36 specific)

PMID:16968818[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00000483

F

Seeded From UniProt

complete

enables

GO:0042054

histone methyltransferase activity

PMID:16968818[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030849

autosome

PMID:20824077[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016571

histone methylation

PMID:16968818[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010452

histone H3-K36 methylation

PMID:16968818[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00000483

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

PMID:12077420[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000805

X chromosome

PMID:20824077[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042054

histone methyltransferase activity

PMID:12077420[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018992

germ-line sex determination

PMID:12077420[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016458

gene silencing

PMID:12077420[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000228

nuclear chromosome

PMID:12077420[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046975

histone methyltransferase activity (H3-K36 specific)

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030486
MGI:MGI:1276545
PANTHER:PTN002739645
PomBase:SPAC29B12.02c
SGD:S000003704
UniProtKB:Q8IE95
UniProtKB:Q96L73
WB:WBGene00003222

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1276545
MGI:MGI:1276574
MGI:MGI:2142581
PANTHER:PTN002739645
SGD:S000003704
UniProtKB:Q8IE95
UniProtKB:Q96L73
UniProtKB:Q9BZ95
WB:WBGene00003040
WB:WBGene00016603

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030486
MGI:MGI:1276545
MGI:MGI:1276574
PANTHER:PTN002739645
SGD:S000003704
TAIR:locus:2030131
TAIR:locus:2126714
UniProtKB:O96028
UniProtKB:Q2LAE1
UniProtKB:Q8IE95
UniProtKB:Q9BZ95
WB:WBGene00003222

C

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0039559
PANTHER:PTN002739645
TAIR:locus:2126714

C

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.43

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Rechtsteiner, A et al. (2010) The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny. PLoS Genet. 6 e1001091 PubMed GONUTS page
  2. 2.0 2.1 Gaydos, LJ et al. (2012) Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells. Cell Rep 2 1169-77 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Bender, LB et al. (2006) MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development 133 3907-17 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Fong, Y et al. (2002) Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Science 296 2235-8 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page