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CAEEL:MES4
Contents
Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
Gene Name(s) | mes-4 | |
Protein Name(s) | Histone-lysine N-methyltransferase mes-4
Maternal-effect sterile protein 4 | |
External Links | ||
UniProt | Q9NH52 | |
EMBL | AF233290 AL021448 | |
PIR | T26577 | |
RefSeq | NP_506333.1 | |
UniGene | Cel.6195 | |
ProteinModelPortal | Q9NH52 | |
SMR | Q9NH52 | |
BioGrid | 44841 | |
IntAct | Q9NH52 | |
MINT | MINT-1040434 | |
STRING | 6239.Y2H9A.1 | |
PaxDb | Q9NH52 | |
EnsemblMetazoa | Y2H9A.1 | |
GeneID | 179824 | |
KEGG | cel:CELE_Y2H9A.1 | |
UCSC | Y2H9A.1 | |
CTD | 43351 | |
WormBase | Y2H9A.1 | |
eggNOG | COG2940 | |
GeneTree | ENSGT00760000118855 | |
InParanoid | Q9NH52 | |
KO | K07117 | |
OMA | CYPAGAR | |
PhylomeDB | Q9NH52 | |
NextBio | 907012 | |
Proteomes | UP000001940 | |
GO | GO:0030849 GO:0005694 GO:0000228 GO:0000805 GO:0042054 GO:0046975 GO:0008270 GO:0016458 GO:0018992 GO:0010452 GO:0016571 GO:0040029 | |
InterPro | IPR003616 IPR001214 IPR001841 | |
Pfam | PF00856 | |
SMART | SM00508 SM00184 SM00317 | |
PROSITE | PS50868 PS50280 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0016571 |
histone methylation |
ECO:0000315 |
P |
"MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline programs." Figure 4: "H3K36me3 levels in mutants are reduced relative to wild type." |
complete | |||||
GO:0016571 |
histone methylation |
ECO:0000315 |
P |
"MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline programs." Figure 4: "H3K36me3 levels in mutants are reduced relative to wild type." |
complete | |||||
involved_in |
GO:0016571 |
histone methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0040029 |
regulation of gene expression, epigenetic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(WBbt:0005784) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010452 |
histone H3-K36 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046975 |
histone methyltransferase activity (H3-K36 specific) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00000483 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042054 |
histone methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0030849 |
autosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016571 |
histone methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010452 |
histone H3-K36 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00000483 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005694 |
chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000805 |
X chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0042054 |
histone methyltransferase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0018992 |
germ-line sex determination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016458 |
gene silencing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000228 |
nuclear chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046975 |
histone methyltransferase activity (H3-K36 specific) |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0030486 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1276545 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0030486 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0000785 |
chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0039559 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Rechtsteiner, A et al. (2010) The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny. PLoS Genet. 6 e1001091 PubMed GONUTS page
- ↑ 2.0 2.1 Gaydos, LJ et al. (2012) Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells. Cell Rep 2 1169-77 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Bender, LB et al. (2006) MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development 133 3907-17 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Fong, Y et al. (2002) Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Science 296 2235-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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