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CAEEL:MES4

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) mes-4
Protein Name(s) Histone-lysine N-methyltransferase mes-4

Maternal-effect sterile protein 4

External Links
UniProt Q9NH52
EMBL AF233290
AL021448
PIR T26577
RefSeq NP_506333.1
UniGene Cel.6195
ProteinModelPortal Q9NH52
SMR Q9NH52
BioGrid 44841
IntAct Q9NH52
MINT MINT-1040434
STRING 6239.Y2H9A.1
PaxDb Q9NH52
EnsemblMetazoa Y2H9A.1
GeneID 179824
KEGG cel:CELE_Y2H9A.1
UCSC Y2H9A.1
CTD 43351
WormBase Y2H9A.1
eggNOG COG2940
GeneTree ENSGT00760000118855
InParanoid Q9NH52
KO K07117
OMA CYPAGAR
PhylomeDB Q9NH52
NextBio 907012
Proteomes UP000001940
GO GO:0030849
GO:0005694
GO:0000228
GO:0000805
GO:0042054
GO:0046975
GO:0008270
GO:0016458
GO:0018992
GO:0010452
GO:0016571
GO:0040029
InterPro IPR003616
IPR001214
IPR001841
Pfam PF00856
SMART SM00508
SM00184
SM00317
PROSITE PS50868
PS50280

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000228

nuclear chromosome

PMID:12077420[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0000805

X chromosome

PMID:20824077[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

GO:0005694

chromosome

PMID:12077420[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0008168

methyltransferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

Seeded From UniProt

complete

GO:0010452

histone H3-K36 methylation

PMID:16968818[3]

IMP: Inferred from Mutant Phenotype

WB:WBVar00000483

P

Seeded From UniProt

complete

GO:0010452

histone H3-K36 methylation

PMID:23103171[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016458

gene silencing

PMID:12077420[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

GO:0016571

histone methylation

PMID:16968818[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016571

histone methylation

PMID:20824077[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016571

histone methylation

PMID:20824077[2]

IMP: Inferred from Mutant Phenotype

P

"MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline programs." Figure 4: "H3K36me3 levels in mutants are reduced relative to wild type."

complete
CACAO 3671

GO:0016571

histone methylation

PMID:20824077[2]

IMP: Inferred from Mutant Phenotype

P

"MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline programs." Figure 4: "H3K36me3 levels in mutants are reduced relative to wild type."

complete
CACAO 3673

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.1.1.43

F

Seeded From UniProt

complete

GO:0018992

germ-line sex determination

PMID:12077420[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030849

autosome

PMID:20824077[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0032259

methylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

GO:0040029

regulation of gene expression, epigenetic

PMID:23103171[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042054

histone methyltransferase activity

PMID:12077420[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0042054

histone methyltransferase activity

PMID:16968818[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0046975

histone methyltransferase activity (H3-K36 specific)

PMID:16968818[3]

IMP: Inferred from Mutant Phenotype

WB:WBVar00000483

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Fong, Y et al. (2002) Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Science 296 2235-8 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Rechtsteiner, A et al. (2010) The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny. PLoS Genet. 6 e1001091 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Bender, LB et al. (2006) MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development 133 3907-17 PubMed GONUTS page
  4. 4.0 4.1 Gaydos, LJ et al. (2012) Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells. Cell Rep 2 1169-77 PubMed GONUTS page