CAEEL:GLR1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	glr-1 (ECO:0000312 with WormBase:C06E1.4)
Protein Name(s)	Glutamate receptor 1 (ECO:0000312 with WormBase:C06E1.4)
External Links
UniProt	P34299
EMBL	U34661 FO080280
PIR	B88533 S60225
RefSeq	NP_498887.2
UniGene	Cel.6005
ProteinModelPortal	P34299
SMR	P34299
BioGrid	41408
IntAct	P34299
STRING	6239.C06E1.4
TCDB	1.A.10.1.21
iPTMnet	P34299
PaxDb	P34299
EnsemblMetazoa	C06E1.4
GeneID	176204
KEGG	cel:CELE_C06E1.4
UCSC	C06E1.4
CTD	176204
WormBase	C06E1.4
eggNOG	KOG1054 ENOG410XPSH
GeneTree	ENSGT00910000143978
HOGENOM	HOG000234372
InParanoid	P34299
KO	K05313
OMA	HAVPYVS
OrthoDB	EOG091G11CB
PhylomeDB	P34299
Reactome	R-CEL-204005 R-CEL-399710 R-CEL-438066 R-CEL-5694530
PRO	PR:P34299
Proteomes	UP000001940
Bgee	WBGene00001612
GO	GO:0030054 GO:0009986 GO:0030425 GO:0008328 GO:0043005 GO:0032589 GO:0043025 GO:0097038 GO:0005886 GO:0014069 GO:0045211 GO:0055037 GO:0045202 GO:0004971 GO:0019899 GO:0005234 GO:0004970 GO:0008344 GO:0008306 GO:0007631 GO:0043056 GO:0046959 GO:0006972 GO:0035235 GO:1905852 GO:1905850 GO:0043058 GO:0010035 GO:0009612 GO:0050913 GO:0007614 GO:0035249 GO:0001966
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR028082 IPR001638
Pfam	PF01094 PF00060 PF10613
PRINTS	PR00177
SMART	SM00918 SM00062 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0045211	postsynaptic membrane	PMID:12123612^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005300) part_of:(WBbt:0005113)	Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	PMID:11717360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006972	hyperosmotic response	PMID:11717360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905850	positive regulation of forward locomotion	PMID:11717360^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5ECN9	P	happens_during:(GO:0009612)	Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:11717360^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5ECN9	P		Seeded From UniProt	complete
involved_in	GO:1905852	positive regulation of backward locomotion	PMID:11717360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0009612)	Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:11717360^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	PMID:24094107^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	PMID:11439453^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046959	habituation	PMID:11439453^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:24094107^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005842)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:24094107^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005842)	Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	PMID:24094107^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005842)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:22213799^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(WBbt:0007804)	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:22213799^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(WBbt:0007804)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:24356955^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0003679)	Seeded From UniProt	complete
involved_in	GO:0043056	forward locomotion	PMID:12123612^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050913	sensory perception of bitter taste	PMID:14988722^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00090490	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:9753322^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:22252129^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005113) part_of:(WBbt:0005829)	Seeded From UniProt	complete
involved_in	GO:0043058	regulation of backward locomotion	PMID:22252129^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088412	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:9753322^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:9753322^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035249	synaptic transmission, glutamatergic	PMID:22958824^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	PMID:7477293^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15371	P		Seeded From UniProt	complete
part_of	GO:0032589	neuron projection membrane	PMID:22958824^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005842)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:22252129^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005113) part_of:(WBbt:0005829)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17761527^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21273419^[13]	ECO:0000353	physical interaction evidence used in manual assertion	WB:WBGene00011216	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:22307086^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:9753322^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00090490	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:7477293^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088412	P		Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	PMID:22958824^[10]	ECO:0000353	physical interaction evidence used in manual assertion	WB:WBGene00004944 WB:WBGene00010587	C	part_of:(WBbt:0005842)	Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	PMID:7477293^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19490	C		Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	PMID:14762140^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088412	P		Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	PMID:22307086^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006972	hyperosmotic response	PMID:22958824^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22252129^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0030425) part_of:(WBbt:0005300)	Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	PMID:7477293^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19490	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	PMID:22958824^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001966	thigmotaxis	PMID:22958824^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043058	regulation of backward locomotion	PMID:11717360^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5ECN9	P	happens_during:(GO:0009612)	Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95808 MGI:MGI:95809 MGI:MGI:95810 MGI:MGI:95811 PANTHER:PTN000438080 RGD:61862 RGD:61863 RGD:621531 RGD:70958	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000438080 RGD:61862 RGD:61863 RGD:621531 RGD:70958 UniProtKB:P42261 UniProtKB:P42263 UniProtKB:P48058	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Burbea, M et al. (2002) Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 35 107-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Kass, J et al. (2001) The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J. Neurosci. 21 9265-72 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Brockie, PJ et al. (2013) Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Neuron 80 129-42 PubMed GONUTS page
↑ ^4.0 ^4.1 Morrison, GE & van der Kooy, D (2001) A mutation in the AMPA-type glutamate receptor, glr-1, blocks olfactory associative and nonassociative learning in Caenorhabditis elegans. Behav. Neurosci. 115 640-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Zhang, D et al. (2012) RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway. J. Cell Biol. 196 85-101 PubMed GONUTS page
↑ Dahlberg, CL & Juo, P (2014) The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. J. Biol. Chem. 289 3444-56 PubMed GONUTS page
↑ Hilliard, MA et al. (2004) Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. EMBO J. 23 1101-11 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Rongo, C et al. (1998) LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94 751-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Park, EC et al. (2012) Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. EMBO J. 31 1379-93 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Wang, R et al. (2012) The SOL-2/Neto auxiliary protein modulates the function of AMPA-subtype ionotropic glutamate receptors. Neuron 75 838-50 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Maricq, AV et al. (1995) Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor. Nature 378 78-81 PubMed GONUTS page
↑ Glodowski, DR et al. (2007) RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway. Mol. Biol. Cell 18 4387-96 PubMed GONUTS page
↑ Kowalski, JR et al. (2011) The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans. J. Neurosci. 31 1341-54 PubMed GONUTS page
↑ ^14.0 ^14.1 Vukojevic, V et al. (2012) A role for α-adducin (ADD-1) in nematode and human memory. EMBO J. 31 1453-66 PubMed GONUTS page
↑ Hills, T et al. (2004) Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J. Neurosci. 24 1217-25 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12123612-1] 1.0 ^1.1 Burbea, M et al. (2002) Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 35 107-20 PubMed GONUTS page

[PMID:11717360-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Kass, J et al. (2001) The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J. Neurosci. 21 9265-72 PubMed GONUTS page

[PMID:24094107-3] 3.0 ^3.1 ^3.2 ^3.3 Brockie, PJ et al. (2013) Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Neuron 80 129-42 PubMed GONUTS page

[PMID:11439453-4] 4.0 ^4.1 Morrison, GE & van der Kooy, D (2001) A mutation in the AMPA-type glutamate receptor, glr-1, blocks olfactory associative and nonassociative learning in Caenorhabditis elegans. Behav. Neurosci. 115 640-9 PubMed GONUTS page

[PMID:22213799-5] 5.0 ^5.1 Zhang, D et al. (2012) RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway. J. Cell Biol. 196 85-101 PubMed GONUTS page

[PMID:24356955-6] Dahlberg, CL & Juo, P (2014) The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. J. Biol. Chem. 289 3444-56 PubMed GONUTS page

[PMID:14988722-7] Hilliard, MA et al. (2004) Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. EMBO J. 23 1101-11 PubMed GONUTS page

[PMID:9753322-8] 8.0 ^8.1 ^8.2 ^8.3 Rongo, C et al. (1998) LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94 751-9 PubMed GONUTS page

[PMID:22252129-9] 9.0 ^9.1 ^9.2 ^9.3 Park, EC et al. (2012) Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. EMBO J. 31 1379-93 PubMed GONUTS page

[PMID:22958824-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Wang, R et al. (2012) The SOL-2/Neto auxiliary protein modulates the function of AMPA-subtype ionotropic glutamate receptors. Neuron 75 838-50 PubMed GONUTS page

[PMID:7477293-11] 11.0 ^11.1 ^11.2 ^11.3 Maricq, AV et al. (1995) Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor. Nature 378 78-81 PubMed GONUTS page

[PMID:17761527-12] Glodowski, DR et al. (2007) RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway. Mol. Biol. Cell 18 4387-96 PubMed GONUTS page

[PMID:21273419-13] Kowalski, JR et al. (2011) The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans. J. Neurosci. 31 1341-54 PubMed GONUTS page

[PMID:22307086-14] 14.0 ^14.1 Vukojevic, V et al. (2012) A role for α-adducin (ADD-1) in nematode and human memory. EMBO J. 31 1453-66 PubMed GONUTS page

[PMID:14762140-15] Hills, T et al. (2004) Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J. Neurosci. 24 1217-25 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:GLR1

Contents

Annotations

Notes

References

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