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PMID:9753322
| Citation |
Rongo, C, Whitfield, CW, Rodal, A, Kim, SK and Kaplan, JM (1998) LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94:751-9 |
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| Abstract |
We tested the model that neurons and epithelial cells use a shared mechanism for polarized protein sorting by comparing the pathways for localizing basolateral and postsynaptic proteins in C. elegans. GLR-1 glutamate receptors are localized to postsynaptic elements of central synapses and, when ectopically expressed, to basolateral membranes of epithelial cells. Proper localization of GLR-1 in both neurons and epithelia requires the PDZ protein LIN-10, defining LIN-10 as a shared component of the basolateral and postsynaptic localization pathways. Changing the GLR-1 carboxy-terminal sequence from a group I PDZ-binding consensus (-TAV) to a group II consensus (-FYV) restores GLR-1 synaptic localization in lin-10 mutants. Thus, these interneurons utilize at least two separate postsynaptic localization pathways. |
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| Keywords |
Animals; Animals, Genetically Modified; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Polarity/physiology; Epithelial Cells/chemistry; Epithelial Cells/cytology; Epithelial Cells/physiology; Genes, Reporter; Green Fluorescent Proteins; Helminth Proteins/genetics; Helminth Proteins/metabolism; Indicators and Reagents; Interneurons/chemistry; Interneurons/cytology; Interneurons/physiology; Luminescent Proteins/genetics; Membrane Proteins/genetics; Proteins; Synapses/chemistry; Synaptic Vesicles/chemistry |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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