CAEEL:G5EEE2

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein TAX-2 (ECO:0000313 with EMBL:CAB04328.1) TAX2 (ECO:0000313 with EMBL:ACQ43993.1)
External Links
UniProt	G5EEE2
EMBL	FJ455695 FJ455696 FJ455697 FJ455698 FJ455699 FJ455700 FJ455701 FJ455702 FJ455703 FJ455704 FJ455705 FJ455706 Z81532 Z93778
PIR	T19627
RefSeq	NP_492427.3
UniGene	Cel.19698
SMR	G5EEE2
TCDB	1.A.1.5.19
EnsemblMetazoa	F36F2.5
GeneID	172723
KEGG	cel:CELE_F36F2.5
CTD	172723
WormBase	F36F2.5
GeneTree	ENSGT00760000118772
KO	K05326
OMA	DEVESPI
OrthoDB	EOG75F4CM
PhylomeDB	G5EEE2
Reactome	REACT_184868 REACT_197698
NextBio	876741
Proteomes	UP000001940
ExpressionAtlas	G5EEE2
GO	GO:0005887 GO:0030553 GO:0005222 GO:0005223 GO:0005249 GO:0009454 GO:0006935 GO:0048812 GO:0007603 GO:0045944 GO:0071805 GO:0030516 GO:0042391 GO:0045664 GO:0055093
Gene3D	2.60.120.10
InterPro	IPR018490 IPR018488 IPR000595 IPR014710
Pfam	PF00027
SMART	SM00100
SUPFAM	SSF51206
PROSITE	PS00888 PS00889 PS50042

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0034703	cation channel complex	PMID:10064800^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010754	negative regulation of cGMP-mediated signaling	PMID:23940325^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0004096)	Seeded From UniProt	complete
involved_in	GO:0070482	response to oxygen levels	PMID:23940325^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0004096)	Seeded From UniProt	complete
involved_in	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	PMID:20436480^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005667)	Seeded From UniProt	complete
contributes_to	GO:0005223	intracellular cGMP-activated cation channel activity	PMID:10064800^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	PMID:10064800^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:7630402^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25303524^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P92172) occurs_in:(WBbt:0005666) occurs_in:(WBbt:0005667)	Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	PMID:15220933^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095119	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:14711416^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095119	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14711416^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095031 WB:WBVar00095119	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	PMID:14711416^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095031 WB:WBVar00095119	P		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	PMID:9486798^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088282 WB:WBVar00095119	P		Seeded From UniProt	complete
involved_in	GO:0009454	aerotaxis	PMID:15220933^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095119	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:9486798^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088282	P		Seeded From UniProt	complete
enables	GO:0030553	cGMP binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000025739 UniProtKB:Q14028 UniProtKB:Q9NQW8	F		Seeded From UniProt	complete
enables	GO:0005223	intracellular cGMP-activated cation channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1353562 PANTHER:PTN000025739 RGD:621809 UniProtKB:Q14028 UniProtKB:Q9NQW8 WB:WBGene00006525	F		Seeded From UniProt	complete
enables	GO:0005222	intracellular cAMP-activated cation channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000025739 RGD:621809	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Komatsu, H et al. (1999) Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res. 821 160-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Couto, A et al. (2013) In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc. Natl. Acad. Sci. U.S.A. 110 E3301-10 PubMed GONUTS page
↑ Liu, J et al. (2010) C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13 715-22 PubMed GONUTS page
↑ Mori, I & Ohshima, Y (1995) Neural regulation of thermotaxis in Caenorhabditis elegans. Nature 376 344-8 PubMed GONUTS page
↑ Meisel, JD et al. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell 159 267-80 PubMed GONUTS page
↑ ^6.0 ^6.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Satterlee, JS et al. (2004) The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr. Biol. 14 62-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Coburn, CM et al. (1998) A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125 249-58 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10064800-1] 1.0 ^1.1 ^1.2 Komatsu, H et al. (1999) Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res. 821 160-8 PubMed GONUTS page

[PMID:23940325-2] 2.0 ^2.1 Couto, A et al. (2013) In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc. Natl. Acad. Sci. U.S.A. 110 E3301-10 PubMed GONUTS page

[PMID:20436480-3] Liu, J et al. (2010) C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13 715-22 PubMed GONUTS page

[PMID:7630402-4] Mori, I & Ohshima, Y (1995) Neural regulation of thermotaxis in Caenorhabditis elegans. Nature 376 344-8 PubMed GONUTS page

[PMID:25303524-5] Meisel, JD et al. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell 159 267-80 PubMed GONUTS page

[PMID:15220933-6] 6.0 ^6.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page

[PMID:14711416-7] 7.0 ^7.1 ^7.2 Satterlee, JS et al. (2004) The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr. Biol. 14 62-8 PubMed GONUTS page

[PMID:9486798-8] 8.0 ^8.1 Coburn, CM et al. (1998) A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125 249-58 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:G5EEE2

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