It is now the 3rd CHALLENGE Period for CACAO Fall 2017! It will end on Sunday October 22, 2017 at 11:59 pm CDT
This is your chance to challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

CAEEL:E2AK3

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) pek-1 (synonyms: eif2ak3)
Protein Name(s) Eukaryotic translation initiation factor 2-alpha kinase

CePEK PEK PRKR-like endoplasmic reticulum kinase PERK

External Links
UniProt Q19192
EMBL AF193341
AF435953
Z66563
Z68104
PIR T20579
RefSeq NP_509912.1
UniGene Cel.7299
ProteinModelPortal Q19192
SMR Q19192
STRING 6239.F46C3.1
PaxDb Q19192
PRIDE Q19192
EnsemblMetazoa F46C3.1
GeneID 181334
KEGG cel:CELE_F46C3.1
UCSC F46C3.1
CTD 181334
WormBase F46C3.1
eggNOG COG0515
GeneTree ENSGT00530000062984
HOGENOM HOG000021070
InParanoid Q19192
KO K08860
OMA GHIVSVW
OrthoDB EOG73NG2X
PhylomeDB Q19192
Reactome REACT_105206
SignaLink Q19192
NextBio 913498
PRO PR:Q19192
Proteomes UP000001940
GO GO:0005789
GO:0016021
GO:0005524
GO:0004694
GO:0004674
GO:0030968
GO:0030308
GO:0045947
GO:0002119
GO:0018105
GO:0006468
GO:0010939
GO:0035966
Gene3D 2.140.10.10
InterPro IPR011009
IPR018391
IPR002372
IPR000719
IPR017441
IPR027295
IPR011047
IPR008271
Pfam PF00069
PF01011
SMART SM00564
SUPFAM SSF50998
SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0002119

nematode larval development

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00002147

P

Seeded From UniProt

complete

GO:0002119

nematode larval development

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00006959

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9Z1Z1

F

Seeded From UniProt

complete

GO:0004694

eukaryotic translation initiation factor 2alpha kinase activity

PMID:10677345[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9Z2B5

C

Seeded From UniProt

complete

GO:0006417

regulation of translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:11779465[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9Z1Z1

P

Seeded From UniProt

complete

GO:0006986

response to unfolded protein

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0834

P

Seeded From UniProt

complete

GO:0010939

regulation of necrotic cell death

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00002147

P

Seeded From UniProt

complete

GO:0010998

regulation of translational initiation by eIF2 alpha phosphorylation

PMID:10677345[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018105

peptidyl-serine phosphorylation

PMID:10677345[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030308

negative regulation of cell growth

PMID:10677345[2]

IGI: Inferred from Genetic Interaction

SGD:S000002691

P

Seeded From UniProt

complete

GO:0030308

negative regulation of cell growth

PMID:10677345[2]

IGI: Inferred from Genetic Interaction

SGD:S000002691
SGD:S000003767

P

Seeded From UniProt

complete

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00002147

P

Seeded From UniProt

complete

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00006959

P

Seeded From UniProt

complete

GO:0030968

endoplasmic reticulum unfolded protein response

PMID:11779465[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00091574

P

Seeded From UniProt

complete

GO:0035966

response to topologically incorrect protein

PMID:23335331[3]

IGI: Inferred from Genetic Interaction

WB:WBGene00002004

P

Seeded From UniProt

complete

GO:0035966

response to topologically incorrect protein

PMID:23335331[3]

IMP: Inferred from Mutant Phenotype

WB:WBVar00091574

P

Seeded From UniProt

complete

GO:0045947

negative regulation of translational initiation

PMID:10677345[2]

IC: Inferred by Curator

GO:0004694

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Sood, R et al. (2000) Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem. J. 346 Pt 2 281-93 PubMed GONUTS page
  3. 3.0 3.1 Schipanski, A et al. (2013) A novel interaction between aging and ER overload in a protein conformational dementia. Genetics 193 865-76 PubMed GONUTS page