CAEEL:E2AK3

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	pek-1 (synonyms: eif2ak3)
Protein Name(s)	Eukaryotic translation initiation factor 2-alpha kinase CePEK PEK PRKR-like endoplasmic reticulum kinase PERK
External Links
UniProt	Q19192
EMBL	AF193341 AF435953 Z66563 Z68104
PIR	T20579
RefSeq	NP_509912.1
UniGene	Cel.7299
ProteinModelPortal	Q19192
SMR	Q19192
STRING	6239.F46C3.1
PaxDb	Q19192
PRIDE	Q19192
EnsemblMetazoa	F46C3.1
GeneID	181334
KEGG	cel:CELE_F46C3.1
UCSC	F46C3.1
CTD	181334
WormBase	F46C3.1
eggNOG	COG0515
GeneTree	ENSGT00530000062984
HOGENOM	HOG000021070
InParanoid	Q19192
KO	K08860
OMA	GHIVSVW
OrthoDB	EOG73NG2X
PhylomeDB	Q19192
Reactome	REACT_105206
SignaLink	Q19192
NextBio	913498
PRO	PR:Q19192
Proteomes	UP000001940
GO	GO:0005789 GO:0016021 GO:0005524 GO:0004694 GO:0004674 GO:0030968 GO:0030308 GO:0045947 GO:0002119 GO:0018105 GO:0006468 GO:0010939 GO:0035966
Gene3D	2.140.10.10
InterPro	IPR011009 IPR018391 IPR002372 IPR000719 IPR017441 IPR027295 IPR011047 IPR008271
Pfam	PF00069 PF01011
SMART	SM00564
SUPFAM	SSF50998 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:20733002^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0001666) has_regulation_target:(UniProtKB:Q19052)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:22719267^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:D0Z5N4,UniProtKB:Q27497	P	has_regulation_target:(UniProtKB:Q19052)	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:22719267^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q19052)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22719267^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P20163) happens_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0045947	negative regulation of translational initiation	PMID:10677345^[3]	ECO:0000305	curator inference used in manual assertion	GO:0004694	P		Seeded From UniProt	complete
involved_in	GO:0035966	response to topologically incorrect protein	PMID:23335331^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00002004	P		Seeded From UniProt	complete
involved_in	GO:0035966	response to topologically incorrect protein	PMID:23335331^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00091574	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:11779465^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00002147	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:11779465^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006959	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:11779465^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00091574	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:10677345^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002691 SGD:S000003767	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:10677345^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002691	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:10677345^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010939	regulation of necrotic cell death	PMID:11779465^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00002147	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11779465^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1Z1	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:11779465^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2B5	C		Seeded From UniProt	complete
enables	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	PMID:10677345^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P20459)	Seeded From UniProt	complete
involved_in	GO:0002119	nematode larval development	PMID:11779465^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006959	P		Seeded From UniProt	complete
involved_in	GO:0002119	nematode larval development	PMID:11779465^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00002147	P		Seeded From UniProt	complete
enables	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002593450 PomBase:SPAC20G4.03c PomBase:SPAC222.07c RGD:70883 UniProtKB:Q9BQI3 WB:WBGene00003970	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103075 MGI:MGI:1341830 MGI:MGI:1353448 MGI:MGI:1353449 PANTHER:PTN000113601 PomBase:SPBC36B7.09 SGD:S000002691 TAIR:locus:2024780 UniProtKB:P19525 UniProtKB:Q8IL26 WB:WBGene00006988 ZFIN:ZDB-GENE-050301-2 ZFIN:ZDB-GENE-080422-1	F		Seeded From UniProt	complete
involved_in	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004694	P		Seeded From UniProt	complete
involved_in	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004694	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mao, XR & Crowder, CM (2010) Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol. Cell. Biol. 30 5033-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Baker, BM et al. (2012) Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. PLoS Genet. 8 e1002760 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Sood, R et al. (2000) Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem. J. 346 Pt 2 281-93 PubMed GONUTS page
↑ ^4.0 ^4.1 Schipanski, A et al. (2013) A novel interaction between aging and ER overload in a protein conformational dementia. Genetics 193 865-76 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20733002-1] Mao, XR & Crowder, CM (2010) Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol. Cell. Biol. 30 5033-42 PubMed GONUTS page

[PMID:22719267-2] 2.0 ^2.1 ^2.2 Baker, BM et al. (2012) Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. PLoS Genet. 8 e1002760 PubMed GONUTS page

[PMID:10677345-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Sood, R et al. (2000) Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem. J. 346 Pt 2 281-93 PubMed GONUTS page

[PMID:23335331-4] 4.0 ^4.1 Schipanski, A et al. (2013) A novel interaction between aging and ER overload in a protein conformational dementia. Genetics 193 865-76 PubMed GONUTS page

[PMID:11779465-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Shen, X et al. (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107 893-903 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:E2AK3

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