It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

CAEEL:DYHC

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) dhc-1
Protein Name(s) Dynein heavy chain, cytoplasmic

Dynein heavy chain, cytosolic DYHC

External Links
UniProt Q19020
EMBL L33260
FO080510
PIR D87755
RefSeq NP_491363.1
UniGene Cel.19011
ProteinModelPortal Q19020
BioGrid 37511
STRING 6239.T21E12.4
PaxDb Q19020
PRIDE Q19020
EnsemblMetazoa T21E12.4
GeneID 172041
KEGG cel:CELE_T21E12.4
UCSC T21E12.4
CTD 172041
WormBase T21E12.4
eggNOG COG5245
GeneTree ENSGT00760000118964
HOGENOM HOG000176055
InParanoid Q19020
KO K10413
OMA NRWVKEI
OrthoDB EOG76471R
PhylomeDB Q19020
NextBio 873787
PRO PR:Q19020
Proteomes UP000001940
GO GO:0005938
GO:0005737
GO:0030286
GO:0005874
GO:0005635
GO:0005819
GO:0000922
GO:0005524
GO:0016887
GO:0003777
GO:0051296
GO:0048814
GO:0008090
GO:0051932
GO:0048489
Gene3D 3.40.50.300
InterPro IPR003593
IPR011704
IPR026983
IPR024743
IPR024317
IPR004273
IPR013594
IPR013602
IPR027417
PANTHER PTHR10676
Pfam PF07728
PF12780
PF08385
PF08393
PF03028
PF12777
SMART SM00382
SUPFAM SSF52540

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0051293

establishment of spindle localization

PMID:23027904[1]

IMP: Inferred from Mutant Phenotype

P

Figure 4.

complete
CACAO 8196

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0000922

spindle pole

PMID:19219036[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0003774

motor activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0243

F

Seeded From UniProt

complete

GO:0003777

microtubule motor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004273
InterPro:IPR026983

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011704

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005635

nuclear envelope

PMID:15616192[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:15616192[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005819

spindle

PMID:15616192[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005819

spindle

PMID:19219036[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:15616192[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007018

microtubule-based movement

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004273
InterPro:IPR026983

P

Seeded From UniProt

complete

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

GO:0008090

retrograde axon cargo transport

PMID:21307258[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004273
InterPro:IPR026983

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011704

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0243

P

Seeded From UniProt

complete

GO:0016887

ATPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011704

F

Seeded From UniProt

complete

GO:0030286

dynein complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004273

C

Seeded From UniProt

complete

GO:0030286

dynein complex

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0243

C

Seeded From UniProt

complete

GO:0048489

synaptic vesicle transport

PMID:16996038[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048814

regulation of dendrite morphogenesis

PMID:21205795[6]

IGI: Inferred from Genetic Interaction

WB:WBGene00016611

P

Seeded From UniProt

complete

GO:0048814

regulation of dendrite morphogenesis

PMID:21205795[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051293

establishment of spindle localization

PMID:23027904[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051296

establishment of meiotic spindle orientation

PMID:19219036[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00006840

P

Seeded From UniProt

complete

GO:0051296

establishment of meiotic spindle orientation

PMID:19219036[2]

IMP: Inferred from Mutant Phenotype

WB:WBVar00094697

P

Seeded From UniProt

complete

GO:0051932

synaptic transmission, GABAergic

PMID:16996038[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00003047

P

Seeded From UniProt

complete

GO:0051932

synaptic transmission, GABAergic

PMID:16996038[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00006762

P

Seeded From UniProt

complete

GO:0051932

synaptic transmission, GABAergic

PMID:16996038[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 van der Voet, M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 11 269-77 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Schmidt, DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol. Biol. Cell 16 1200-12 PubMed GONUTS page
  4. Arimoto, M et al. (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31 2216-24 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Locke, CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 1120 23-34 PubMed GONUTS page
  6. 6.0 6.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page