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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.
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CAEEL:DYHC
Contents
| Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
| Gene Name(s) | dhc-1 | |
| Protein Name(s) | Dynein heavy chain, cytoplasmic
Dynein heavy chain, cytosolic DYHC | |
| External Links | ||
| UniProt | Q19020 | |
| EMBL | L33260 FO080510 | |
| PIR | D87755 | |
| RefSeq | NP_491363.1 | |
| UniGene | Cel.19011 | |
| ProteinModelPortal | Q19020 | |
| BioGrid | 37511 | |
| STRING | 6239.T21E12.4 | |
| PaxDb | Q19020 | |
| PRIDE | Q19020 | |
| EnsemblMetazoa | T21E12.4 | |
| GeneID | 172041 | |
| KEGG | cel:CELE_T21E12.4 | |
| UCSC | T21E12.4 | |
| CTD | 172041 | |
| WormBase | T21E12.4 | |
| eggNOG | COG5245 | |
| GeneTree | ENSGT00760000118964 | |
| HOGENOM | HOG000176055 | |
| InParanoid | Q19020 | |
| KO | K10413 | |
| OMA | NRWVKEI | |
| OrthoDB | EOG76471R | |
| PhylomeDB | Q19020 | |
| NextBio | 873787 | |
| PRO | PR:Q19020 | |
| Proteomes | UP000001940 | |
| GO | GO:0005938 GO:0005737 GO:0030286 GO:0005874 GO:0005635 GO:0005819 GO:0000922 GO:0005524 GO:0016887 GO:0003777 GO:0051296 GO:0048814 GO:0008090 GO:0051932 GO:0048489 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR003593 IPR011704 IPR026983 IPR024743 IPR024317 IPR004273 IPR013594 IPR013602 IPR027417 | |
| PANTHER | PTHR10676 | |
| Pfam | PF07728 PF12780 PF08385 PF08393 PF03028 PF12777 | |
| SMART | SM00382 | |
| SUPFAM | SSF52540 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0051293 |
establishment of spindle localization |
IMP: Inferred from Mutant Phenotype |
P |
Figure 4. |
complete | |||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0000922 |
spindle pole |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0003774 |
motor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0003777 |
microtubule motor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0005635 |
nuclear envelope |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0005819 |
spindle |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0005819 |
spindle |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0005856 |
cytoskeleton |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0005856 |
cytoskeleton |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0005874 |
microtubule |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0005938 |
cell cortex |
IDA: Inferred from Direct Assay |
C |
Seeded From UniProt |
complete | |||
| GO:0007018 |
microtubule-based movement |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0007399 |
nervous system development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0008090 |
retrograde axon cargo transport |
IMP: Inferred from Mutant Phenotype |
P |
Seeded From UniProt |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
complete | |||
| GO:0016887 |
ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
complete | |||
| GO:0030286 |
dynein complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0030286 |
dynein complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
complete | |||
| GO:0048489 |
synaptic vesicle transport |
IMP: Inferred from Mutant Phenotype |
P |
Seeded From UniProt |
complete | |||
| GO:0048814 |
regulation of dendrite morphogenesis |
IGI: Inferred from Genetic Interaction |
WB:WBGene00016611 |
P |
Seeded From UniProt |
complete | ||
| GO:0048814 |
regulation of dendrite morphogenesis |
IMP: Inferred from Mutant Phenotype |
P |
Seeded From UniProt |
complete | |||
| GO:0051293 |
establishment of spindle localization |
IMP: Inferred from Mutant Phenotype |
P |
Seeded From UniProt |
complete | |||
| GO:0051296 |
establishment of meiotic spindle orientation |
IGI: Inferred from Genetic Interaction |
WB:WBGene00006840 |
P |
Seeded From UniProt |
complete | ||
| GO:0051296 |
establishment of meiotic spindle orientation |
IMP: Inferred from Mutant Phenotype |
WB:WBVar00094697 |
P |
Seeded From UniProt |
complete | ||
| GO:0051932 |
synaptic transmission, GABAergic |
IGI: Inferred from Genetic Interaction |
WB:WBGene00003047 |
P |
Seeded From UniProt |
complete | ||
| GO:0051932 |
synaptic transmission, GABAergic |
IGI: Inferred from Genetic Interaction |
WB:WBGene00006762 |
P |
Seeded From UniProt |
complete | ||
| GO:0051932 |
synaptic transmission, GABAergic |
IMP: Inferred from Mutant Phenotype |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 van der Voet, M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 11 269-77 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Schmidt, DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol. Biol. Cell 16 1200-12 PubMed GONUTS page
- ↑ Arimoto, M et al. (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31 2216-24 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Locke, CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 1120 23-34 PubMed GONUTS page
- ↑ 6.0 6.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page
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