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CAEEL:DYHC
Contents
Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
Gene Name(s) | dhc-1 | |
Protein Name(s) | Dynein heavy chain, cytoplasmic
Dynein heavy chain, cytosolic DYHC | |
External Links | ||
UniProt | Q19020 | |
EMBL | L33260 FO080510 | |
PIR | D87755 | |
RefSeq | NP_491363.1 | |
UniGene | Cel.19011 | |
ProteinModelPortal | Q19020 | |
BioGrid | 37511 | |
STRING | 6239.T21E12.4 | |
PaxDb | Q19020 | |
PRIDE | Q19020 | |
EnsemblMetazoa | T21E12.4 | |
GeneID | 172041 | |
KEGG | cel:CELE_T21E12.4 | |
UCSC | T21E12.4 | |
CTD | 172041 | |
WormBase | T21E12.4 | |
eggNOG | COG5245 | |
GeneTree | ENSGT00760000118964 | |
HOGENOM | HOG000176055 | |
InParanoid | Q19020 | |
KO | K10413 | |
OMA | NRWVKEI | |
OrthoDB | EOG76471R | |
PhylomeDB | Q19020 | |
NextBio | 873787 | |
PRO | PR:Q19020 | |
Proteomes | UP000001940 | |
GO | GO:0005938 GO:0005737 GO:0030286 GO:0005874 GO:0005635 GO:0005819 GO:0000922 GO:0005524 GO:0016887 GO:0003777 GO:0051296 GO:0048814 GO:0008090 GO:0051932 GO:0048489 | |
Gene3D | 3.40.50.300 | |
InterPro | IPR003593 IPR011704 IPR026983 IPR024743 IPR024317 IPR004273 IPR013594 IPR013602 IPR027417 | |
PANTHER | PTHR10676 | |
Pfam | PF07728 PF12780 PF08385 PF08393 PF03028 PF12777 | |
SMART | SM00382 | |
SUPFAM | SSF52540 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0051293 |
establishment of spindle localization |
ECO:0000315 |
P |
Figure 4. |
complete | |||||
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051661 |
maintenance of centrosome location |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1904811 |
positive regulation of dense core granule transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1990048 |
anterograde neuronal dense core vesicle transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1902473 |
regulation of protein localization to synapse |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0016322 |
neuron remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0051293 |
establishment of spindle localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048814 |
regulation of dendrite morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00016611 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048814 |
regulation of dendrite morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008090 |
retrograde axonal transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00006762 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00003047 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051296 |
establishment of meiotic spindle orientation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00006840 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051296 |
establishment of meiotic spindle orientation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00094697 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048489 |
synaptic vesicle transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005819 |
spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005819 |
spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000922 |
spindle pole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072382 |
minus-end-directed vesicle transport along microtubule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000072732 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051959 |
dynein light intermediate chain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103147 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0045505 |
dynein intermediate chain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000743491 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0045503 |
dynein light chain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000743491 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031122 |
cytoplasmic microtubule organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000072732 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030286 |
dynein complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261797 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008569 |
ATP-dependent microtubule motor activity, minus-end-directed |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000743491 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007018 |
microtubule-based movement |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261797 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005868 |
cytoplasmic dynein complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000072732 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048489 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008090 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:1990048 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003777 |
microtubule motor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007018 |
microtubule-based movement |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030286 |
dynein complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030286 |
dynein complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003774 |
motor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
- ↑ Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page
- ↑ Fortin, SM et al. (2010) The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev. Biol. 344 992-1000 PubMed GONUTS page
- ↑ 4.0 4.1 Goodwin, PR et al. (2012) Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J. Neurosci. 32 8158-72 PubMed GONUTS page
- ↑ 5.0 5.1 Park, M et al. (2011) CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron 70 742-57 PubMed GONUTS page
- ↑ 6.0 6.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page
- ↑ Arimoto, M et al. (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31 2216-24 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Locke, CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 1120 23-34 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 van der Voet, M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 11 269-77 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Schmidt, DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol. Biol. Cell 16 1200-12 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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