CAEEL:DYHC

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	dhc-1
Protein Name(s)	Dynein heavy chain, cytoplasmic Dynein heavy chain, cytosolic DYHC
External Links
UniProt	Q19020
EMBL	L33260 FO080510
PIR	D87755
RefSeq	NP_491363.1
UniGene	Cel.19011
ProteinModelPortal	Q19020
BioGrid	37511
STRING	6239.T21E12.4
PaxDb	Q19020
PRIDE	Q19020
EnsemblMetazoa	T21E12.4
GeneID	172041
KEGG	cel:CELE_T21E12.4
UCSC	T21E12.4
CTD	172041
WormBase	T21E12.4
eggNOG	COG5245
GeneTree	ENSGT00760000118964
HOGENOM	HOG000176055
InParanoid	Q19020
KO	K10413
OMA	NRWVKEI
OrthoDB	EOG76471R
PhylomeDB	Q19020
NextBio	873787
PRO	PR:Q19020
Proteomes	UP000001940
GO	GO:0005938 GO:0005737 GO:0030286 GO:0005874 GO:0005635 GO:0005819 GO:0000922 GO:0005524 GO:0016887 GO:0003777 GO:0051296 GO:0048814 GO:0008090 GO:0051932 GO:0048489
Gene3D	3.40.50.300
InterPro	IPR003593 IPR011704 IPR026983 IPR024743 IPR024317 IPR004273 IPR013594 IPR013602 IPR027417
PANTHER	PTHR10676
Pfam	PF07728 PF12780 PF08385 PF08393 PF03028 PF12777
SMART	SM00382
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051293	establishment of spindle localization	PMID:23027904^[1]	ECO:0000315			P		Figure 4.	complete CACAO 8196
part_of	GO:0000776	kinetochore	PMID:18765790^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051661	maintenance of centrosome location	PMID:20599902^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904811	positive regulation of dense core granule transport	PMID:22699897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005274) occurs_in:(GO:0030424)	Seeded From UniProt	complete
involved_in	GO:1990048	anterograde neuronal dense core vesicle transport	PMID:22699897^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005274) occurs_in:(GO:0030425)	Seeded From UniProt	complete
involved_in	GO:1902473	regulation of protein localization to synapse	PMID:21609829^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0002164) regulates_o_occurs_in:(WBbt:0005270) part_of:(GO:0016322)	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:21609829^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0002164) results_in_maturation_of:(WBbt:0005270)	Seeded From UniProt	complete
involved_in	GO:0051293	establishment of spindle localization	PMID:23027904^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21205795^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00016611	P		Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21205795^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008090	retrograde axonal transport	PMID:21307258^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051932	synaptic transmission, GABAergic	PMID:16996038^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006762	P		Seeded From UniProt	complete
involved_in	GO:0051932	synaptic transmission, GABAergic	PMID:16996038^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00003047	P		Seeded From UniProt	complete
involved_in	GO:0051932	synaptic transmission, GABAergic	PMID:16996038^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051296	establishment of meiotic spindle orientation	PMID:19219036^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006840	P		Seeded From UniProt	complete
involved_in	GO:0051296	establishment of meiotic spindle orientation	PMID:19219036^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00094697	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	PMID:16996038^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:15616192^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:15616192^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:19219036^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15616192^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:15616192^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:19219036^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072382	minus-end-directed vesicle transport along microtubule	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000072732 dictyBase:DDB_G0276355	P		Seeded From UniProt	complete
enables	GO:0051959	dynein light intermediate chain binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103147 PANTHER:PTN000743491 RGD:71042 UniProtKB:Q14204	F		Seeded From UniProt	complete
enables	GO:0045505	dynein intermediate chain binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743491 dictyBase:DDB_G0276355	F		Seeded From UniProt	complete
enables	GO:0045503	dynein light chain binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743491 UniProtKB:A8I3X6 UniProtKB:A8I5C3 UniProtKB:A8ISA6 UniProtKB:A8IV22 UniProtKB:A8JDH8 UniProtKB:Q9SMH5	F		Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000072732 dictyBase:DDB_G0276355	P		Seeded From UniProt	complete
part_of	GO:0030286	dynein complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261797 PANTHER:PTN000743491 UniProtKB:Q96JB1 UniProtKB:Q9SMH5	C		Seeded From UniProt	complete
enables	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743491 SGD:S000001762 UniProtKB:A8JDH8 UniProtKB:P45444 UniProtKB:Q14204 UniProtKB:Q8NCM8	F		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261797 PANTHER:PTN000743491	P		Seeded From UniProt	complete
part_of	GO:0005868	cytoplasmic dynein complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000072732 PomBase:SPAC1093.06c SGD:S000001762 UniProtKB:P45444 UniProtKB:Q14204 dictyBase:DDB_G0276355	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048489	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008090	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1990048	C		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004273 InterPro:IPR026983	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035699	F		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004273 InterPro:IPR026983	P		Seeded From UniProt	complete
part_of	GO:0030286	dynein complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004273	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0030286	dynein complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0243	C		Seeded From UniProt	complete
enables	GO:0003774	motor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0243	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
↑ Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page
↑ Fortin, SM et al. (2010) The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev. Biol. 344 992-1000 PubMed GONUTS page
↑ ^4.0 ^4.1 Goodwin, PR et al. (2012) Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J. Neurosci. 32 8158-72 PubMed GONUTS page
↑ ^5.0 ^5.1 Park, M et al. (2011) CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron 70 742-57 PubMed GONUTS page
↑ ^6.0 ^6.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page
↑ Arimoto, M et al. (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31 2216-24 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Locke, CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 1120 23-34 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 van der Voet, M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 11 269-77 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Schmidt, DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol. Biol. Cell 16 1200-12 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23027904-1] 1.0 ^1.1 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page

[PMID:18765790-2] Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page

[PMID:20599902-3] Fortin, SM et al. (2010) The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev. Biol. 344 992-1000 PubMed GONUTS page

[PMID:22699897-4] 4.0 ^4.1 Goodwin, PR et al. (2012) Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J. Neurosci. 32 8158-72 PubMed GONUTS page

[PMID:21609829-5] 5.0 ^5.1 Park, M et al. (2011) CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron 70 742-57 PubMed GONUTS page

[PMID:21205795-6] 6.0 ^6.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page

[PMID:21307258-7] Arimoto, M et al. (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31 2216-24 PubMed GONUTS page

[PMID:16996038-8] 8.0 ^8.1 ^8.2 ^8.3 Locke, CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 1120 23-34 PubMed GONUTS page

[PMID:19219036-9] 9.0 ^9.1 ^9.2 ^9.3 van der Voet, M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 11 269-77 PubMed GONUTS page

[PMID:15616192-10] 10.0 ^10.1 ^10.2 ^10.3 Schmidt, DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol. Biol. Cell 16 1200-12 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:DYHC

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