GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

CAEEL:DYHC

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) dhc-1
Protein Name(s) Dynein heavy chain, cytoplasmic

Dynein heavy chain, cytosolic DYHC

External Links
UniProt Q19020
EMBL L33260
FO080510
PIR D87755
RefSeq NP_491363.1
UniGene Cel.19011
ProteinModelPortal Q19020
BioGrid 37511
STRING 6239.T21E12.4
PaxDb Q19020
PRIDE Q19020
EnsemblMetazoa T21E12.4
GeneID 172041
KEGG cel:CELE_T21E12.4
UCSC T21E12.4
CTD 172041
WormBase T21E12.4
eggNOG COG5245
GeneTree ENSGT00760000118964
HOGENOM HOG000176055
InParanoid Q19020
KO K10413
OMA NRWVKEI
OrthoDB EOG76471R
PhylomeDB Q19020
NextBio 873787
PRO PR:Q19020
Proteomes UP000001940
GO GO:0005938
GO:0005737
GO:0030286
GO:0005874
GO:0005635
GO:0005819
GO:0000922
GO:0005524
GO:0016887
GO:0003777
GO:0051296
GO:0048814
GO:0008090
GO:0051932
GO:0048489
Gene3D 3.40.50.300
InterPro IPR003593
IPR011704
IPR026983
IPR024743
IPR024317
IPR004273
IPR013594
IPR013602
IPR027417
PANTHER PTHR10676
Pfam PF07728
PF12780
PF08385
PF08393
PF03028
PF12777
SMART SM00382
SUPFAM SSF52540

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051293

establishment of spindle localization

PMID:23027904[1]

ECO:0000315

P

Figure 4.

complete
CACAO 8196

part_of

GO:0000776

kinetochore

PMID:18765790[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051661

maintenance of centrosome location

PMID:20599902[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904811

positive regulation of dense core granule transport

PMID:22699897[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990048

anterograde neuronal dense core vesicle transport

PMID:22699897[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902473

regulation of protein localization to synapse

PMID:21609829[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016322

neuron remodeling

PMID:21609829[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • part_of:(GO:0002164)
  • results_in_maturation_of:(WBbt:0005270)

Seeded From UniProt

complete

involved_in

GO:0051293

establishment of spindle localization

PMID:23027904[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048814

regulation of dendrite morphogenesis

PMID:21205795[6]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00016611

P

Seeded From UniProt

complete

involved_in

GO:0048814

regulation of dendrite morphogenesis

PMID:21205795[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008090

retrograde axonal transport

PMID:21307258[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051932

synaptic transmission, GABAergic

PMID:16996038[8]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00006762

P

Seeded From UniProt

complete

involved_in

GO:0051932

synaptic transmission, GABAergic

PMID:16996038[8]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00003047

P

Seeded From UniProt

complete

involved_in

GO:0051932

synaptic transmission, GABAergic

PMID:16996038[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051296

establishment of meiotic spindle orientation

PMID:19219036[9]

ECO:0000316

genetic interaction evidence used in manual assertion

WB:WBGene00006840

P

Seeded From UniProt

complete

involved_in

GO:0051296

establishment of meiotic spindle orientation

PMID:19219036[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

WB:WBVar00094697

P

Seeded From UniProt

complete

involved_in

GO:0048489

synaptic vesicle transport

PMID:16996038[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:15616192[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:15616192[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:19219036[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15616192[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:15616192[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:19219036[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072382

minus-end-directed vesicle transport along microtubule

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000072732
dictyBase:DDB_G0276355

P

Seeded From UniProt

complete

enables

GO:0051959

dynein light intermediate chain binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103147
PANTHER:PTN000743491
RGD:71042
UniProtKB:Q14204

F

Seeded From UniProt

complete

enables

GO:0045505

dynein intermediate chain binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000743491
dictyBase:DDB_G0276355

F

Seeded From UniProt

complete

enables

GO:0045503

dynein light chain binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000743491
UniProtKB:A8I3X6
UniProtKB:A8I5C3
UniProtKB:A8ISA6
UniProtKB:A8IV22
UniProtKB:A8JDH8
UniProtKB:Q9SMH5

F

Seeded From UniProt

complete

involved_in

GO:0031122

cytoplasmic microtubule organization

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000072732
dictyBase:DDB_G0276355

P

Seeded From UniProt

complete

part_of

GO:0030286

dynein complex

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261797
PANTHER:PTN000743491
UniProtKB:Q96JB1
UniProtKB:Q9SMH5

C

Seeded From UniProt

complete

enables

GO:0008569

ATP-dependent microtubule motor activity, minus-end-directed

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000743491
SGD:S000001762
UniProtKB:A8JDH8
UniProtKB:P45444
UniProtKB:Q14204
UniProtKB:Q8NCM8

F

Seeded From UniProt

complete

involved_in

GO:0007018

microtubule-based movement

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261797
PANTHER:PTN000743491

P

Seeded From UniProt

complete

part_of

GO:0005868

cytoplasmic dynein complex

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000072732
PomBase:SPAC1093.06c
SGD:S000001762
UniProtKB:P45444
UniProtKB:Q14204
dictyBase:DDB_G0276355

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048489

C

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008090

C

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1990048

C

Seeded From UniProt

complete

enables

GO:0003777

microtubule motor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004273
InterPro:IPR026983

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR035699

F

Seeded From UniProt

complete

involved_in

GO:0007018

microtubule-based movement

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004273
InterPro:IPR026983

P

Seeded From UniProt

complete

part_of

GO:0030286

dynein complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004273

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

part_of

GO:0030286

dynein complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0243

C

Seeded From UniProt

complete

enables

GO:0003774

motor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0243

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kotak, S et al. (2012) Cortical dynein is critical for proper spindle positioning in human cells. J. Cell Biol. 199 97-110 PubMed GONUTS page
  2. Gassmann, R et al. (2008) A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 22 2385-99 PubMed GONUTS page
  3. Fortin, SM et al. (2010) The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev. Biol. 344 992-1000 PubMed GONUTS page
  4. 4.0 4.1 Goodwin, PR et al. (2012) Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J. Neurosci. 32 8158-72 PubMed GONUTS page
  5. 5.0 5.1 Park, M et al. (2011) CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron 70 742-57 PubMed GONUTS page
  6. 6.0 6.1 Aguirre-Chen, C et al. (2011) C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development 138 507-18 PubMed GONUTS page
  7. Arimoto, M et al. (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J. Neurosci. 31 2216-24 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Locke, CJ et al. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 1120 23-34 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 van der Voet, M et al. (2009) NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 11 269-77 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Schmidt, DJ et al. (2005) Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol. Biol. Cell 16 1200-12 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page