BPT4:HOLIN

Species (Taxon ID)	Enterobacteria phage T4 (Bacteriophage T4). (10665)
Gene Name(s)	t (synonyms: rV)
Protein Name(s)	Holin (ECO:0000255 with HAMAP-Rule:MF_04104) Lysis protein Protein rV
External Links
UniProt	P06808
EMBL	Y00408 AF158101 X05677 M99441
PIR	JF0028
RefSeq	NP_049865.1
TCDB	1.E.8.1.1
GeneID	1258610
KEGG	vg:1258610
Proteomes	UP000009087
GO	GO:0020002 GO:0016021 GO:0034291 GO:0019835
HAMAP	MF_04104
InterPro	IPR020982
Pfam	PF11031

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0034291	canonical holin activity	PMID:11459934	ECO:0000314	direct assay evidence used in manual assertion		F		Figure 2 shows the microscopic images of the bacterial cells pre and post induction of the Lambda lysis genes. Before the induction of the lysis genes, there was an abundant amount of bacterial cells present. After 25 minutes of the induction of the Lambda lysis genes, the amount of bacterial cells significantly decreased, showing that the cells were broken apart and lysed.	complete CACAO 12881
	GO:0019835	cytolysis	PMID:22389108	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 2, plots a graph with A550 on the y axis and time of induction (min) on the x axis. The graph illustrated how the alleles tQ87am and tQ209am contain partial Holin activity. When the two alleles are present in the sample; the turbidity decrease indicating the bacteria has died, due to lysis activity. The alleles tQ87am and tQ209am supports gradual lysis after 40 min and 75 min, respectively.	complete CACAO 12886
involved_in	GO:0044660	cytolysis by virus via pore formation in host cell membrane	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0034291	P		Seeded From UniProt	complete
involved_in	GO:0044660	cytolysis by virus via pore formation in host cell membrane	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0034291	P		Seeded From UniProt	complete
involved_in	GO:0044659	cytolysis by virus of host cell	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020982	P		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000413067	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000413067	C		Seeded From UniProt	complete
enables	GO:0034291	canonical holin activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000413067	F		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1030 UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0373	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
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