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|Species (Taxon ID)||Enterobacteria phage T4 (Bacteriophage T4). (10665)|
|Gene Name(s)||39.2 (ECO:0000313 with EMBL:ADJ39725.1)|
|Protein Name(s)||Uncharacterized protein 39.2 (ECO:0000313 with EMBL:ADJ39725.1)|
|Qualifier||GO ID||GO term name||Reference||ECO ID||ECO term name||with/from||Aspect||Extension||Notes||Status|
regulation of protein folding
colony counting evidence used in manual assertion
Gp39.2, which is a bacteriophage T4 protein, is believed to modulate the host's (E. coli) GroEL/GroES chaperone machine, which aids in the correct folding of both host and bacteriophage proteins. Gp39.2 is thought to play a part in correctly folding the E. coli host protein UmuC, which is part of the DNA Polymerase V complex. The authors believe that the GroEL/GroES complex is required for the DNA PolV to work and proofread in the bacteria cell. This relationship between Gp39.2 and DNA PolV is illustrated in Figure 5 where an E. coli mutant (that was only a mutant for isolation purposes for plating) was plated with and without the plasmid containing Gp39.2. The bacterium were then exposed to UV irradiation and were grown with and without arabinose, which showed which mutant bacteria had Gp39.2 in them. The Gp39.2 mutant bacteria were much more frequently seen while plating as opposed to the non-Gp39.2 mutant bacteria.
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