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BORBU:O51190
Contents
| Species (Taxon ID) | Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM4680). (224326) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | DnaK suppressor, putative (ECO:0000313 with EMBL:AAC66562.1) | |
| External Links | ||
| UniProt | O51190 | |
| EMBL | AE000783 | |
| PIR | H70120 | |
| RefSeq | NP_212302.1 WP_002663978.1 | |
| ProteinModelPortal | O51190 | |
| SMR | O51190 | |
| STRING | 224326.BB_0168 | |
| PRIDE | O51190 | |
| EnsemblBacteria | AAC66562 | |
| GeneID | 1195003 | |
| KEGG | bbu:BB_0168 | |
| PATRIC | fig|224326.49.peg.565 | |
| eggNOG | ENOG4105W8N COG1734 | |
| OMA | CKEEINE | |
| BioCyc | BBUR224326:G9SO-161-MONOMER | |
| Proteomes | UP000001807 | |
| GO | GO:0008270 | |
| InterPro | IPR037187 IPR000962 | |
| Pfam | PF01258 | |
| SUPFAM | SSF109635 | |
| PROSITE | PS51128 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
||||
| GO:0015972 |
guanosine pentaphosphate metabolic process |
ECO:0007110 |
thin layer chromatography evidence used in manual assertion |
P |
The authors generated a mutant strain of Borrelia burgdorferi with the dksA gene knocked out. Using thin-layer chromatography, they measured the levels of (p)ppGpp produced by both wild-type and ΔdksA mutants under starvation conditions (figure 7A). When these results were quantified and normalized to levels of (p)ppGpp+GTP, the authors found that the ΔdksA mutant produced significantly higher levels of (p)ppGpp than wild-type (figure 7B). Reinsertion of the dksA gene through a plasmid vector containing the dksA ORF (pDksA) restored production levels of (p)ppGpp comparable to that of the wild-type strain. This indicates that the dksA gene plays a role in regulation of guanosine pentaphosphate metabolism. |
complete | ||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Boyle, WK et al. (2019) DksA Controls the Response of the Lyme Disease Spirochete to Starvation. J. Bacteriol. 201 PubMed GONUTS page
