BACSU:SIRA

Species (Taxon ID)	Bacillus subtilis (strain 168). (224308)
Gene Name(s)	sirA (synonyms: yneE, yoxF)
Protein Name(s)	Sporulation inhibitor of replication protein SirA
External Links
UniProt	P45707
EMBL	X87845 Z73234 AL009126
PIR	S57402
RefSeq	NP_389673.1
PDB	4TPS
PDBsum	4TPS
IntAct	P45707
STRING	224308.BSU17900
PaxDb	P45707
EnsemblBacteria	CAB13674
GeneID	936340
KEGG	bsu:BSU17900
PATRIC	18975409
GenoList	BSU17900
eggNOG	NOG15839
HOGENOM	HOG000095559
OMA	DEFANHY
OrthoDB	EOG67HJVJ
BioCyc	BSUB:BSU17900-MONOMER
Proteomes	UP000001570
GO	GO:0008156 GO:0030435
InterPro	IPR019683
Pfam	PF10747

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008156	negative regulation of DNA replication	PMID:21239581	ECO:0000315			P		Fig. 5 indicates that SirA reduces the amount of wild-type but not mutant DnaA bound at the origin of replication. Therefore this results indicate that interaction of SirA contacts DnaA at a patch of 3 residues located on the surface of domain I of the replication initiator protein and inhibits the ability of DNA to bind to the origin of replication.	complete CACAO 4782
involved_in	GO:0030435	sporulation resulting in formation of a cellular spore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0749	P		Seeded From UniProt	complete
involved_in	GO:0008156	negative regulation of DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0236	P		Seeded From UniProt	complete
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References

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